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Context parallelism (CP) has been widely adopted to support the growing context length in foundation model pretraining. However, existing designs fail to handle the large variation in sequence length from training datasets, resulting in…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-12 Yilong Zhao , Xiaonan Nie , Kan Zhu , Shuang Ma , Zhichao Lai , Hongxiang Hao , Yang Zhou , Baris Kasikci , Ion Stoica

The Cellular Potts Model (CPM) is a widely used simulation paradigm for systems of interacting cells that has been used to study scenarios ranging from plant development to morphogenesis, tumour growth and cell migration. Despite their wide…

Tissues and Organs · Quantitative Biology 2023-12-18 Shabaz Sultan , Sapna Devi , Scott N. Mueller , Johannes Textor

We present context parallelism for long-context large language model inference, which achieves near-linear scaling for long-context prefill latency with up to 128 H100 GPUs across 16 nodes. Particularly, our method achieves 1M context…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-22 Amy Yang , Jingyi Yang , Aya Ibrahim , Xinfeng Xie , Bangsheng Tang , Grigory Sizov , Jeremy Reizenstein , Jongsoo Park , Jianyu Huang

The rapid adoption of large language models (LLMs) has shifted a substantial portion of inference workloads into throughput-oriented offline regimes, where fully utilizing GPU compute requires large batch sizes. However, existing…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-28 Alan Zhao , Cyril Y. He

AlphaFold predicts protein structures from the amino acid sequence at or near experimental resolution, solving the 50-year-old protein folding challenge, leading to progress by transforming large-scale genomics data into protein structures.…

Biomolecules · Quantitative Biology 2021-11-16 Bozitao Zhong , Xiaoming Su , Minhua Wen , Sichen Zuo , Liang Hong , James Lin

Realistic simulations of detailed, biophysics-based, multi-scale models require very high resolution and, thus, large-scale compute facilities. Existing simulation environments, especially for biomedical applications, are designed to allow…

Computational Engineering, Finance, and Science · Computer Science 2018-02-12 Chris Bradley , Nehzat Emamy , Thomas Ertl , Dominik Göddeke , Andreas Hessenthaler , Thomas Klotz , Aaron Krämer , Michael Krone , Benjamin Maier , Miriam Mehl , Tobias Rau , Oliver Röhrle

Histopathologic diagnosis relies on simultaneous integration of information from a broad range of scales, ranging from nuclear aberrations ($\approx \mathcal{O}(0.1{\mu m})$) through cellular structures ($\approx \mathcal{O}(10{\mu m})$) to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Rüdiger Schmitz , Frederic Madesta , Maximilian Nielsen , Jenny Krause , René Werner , Thomas Rösch

Evolution can be broadly described in terms of mutations of the genotype and the subsequent selection of the phenotype. The full enumeration of a given genotype-phenotype (GP) map is therefore a powerful technique in examining evolutionary…

Biomolecules · Quantitative Biology 2020-11-30 S. Owen

Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

Hardware Architecture · Computer Science 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

Vertex models represent confluent tissue by polygonal or polyhedral tilings of space, with the individual cell interacting via force laws that depend on both the geometry of the cells and the topology of the tessellation. This dependence on…

Biological Physics · Physics 2017-09-13 Daniel M. Sussman

Mixture-of-Experts (MoE) models scale large language models through conditional computation, but inference becomes memory-bound once expert weights exceed the capacity of GPU memory. In this case, weights must be offloaded to external…

Machine Learning · Computer Science 2025-12-05 Zehao Fan , Zhenyu Liu , Yunzhen Liu , Yayue Hou , Hadjer Benmeziane , Kaoutar El Maghraoui , Liu Liu

Micro-macro models provide a powerful tool to study the relationship between microscale mechanisms and emergent macroscopic behavior. However, the detailed microscopic modeling may require tracking and evolving a high-dimensional…

Computational Physics · Physics 2019-08-13 Steven Cook , Tamar Shinar

Dynamic programming (DP) is a cornerstone of combinatorial optimization, yet its inherently sequential structure has long limited its scalability in scenario-based stochastic programming (SP). This paper introduces a GPU-accelerated…

Optimization and Control · Mathematics 2025-11-25 Jingyi Zhao , Linxin Yang , Haohua Zhang , Tian Ding

Highly accurate biomolecular structure prediction is a key component of developing biomolecular foundation models, and one of the most critical aspects of building foundation models is identifying the recipes for scaling the model. In this…

Biomolecules · Quantitative Biology 2026-01-02 Yi Zhou , Chan Lu , Yiming Ma , Wei Qu , Fei Ye , Kexin Zhang , Lan Wang , Minrui Gui , Quanquan Gu

Pipeline Parallelism (PP) serves as a crucial technique for training Large Language Models (LLMs), owing to its capability to alleviate memory pressure from model states with relatively low communication overhead. However, in long-context…

Machine Learning · Computer Science 2025-04-22 Zhouyang Li , Yuliang Liu , Wei Zhang , Tailing Yuan , Bin Chen , Chengru Song , Di Zhang

The transition from standard generative AI to \emph{reasoning-centric architectures}, exemplified by models capable of extensive Chain-of-Thought~(CoT) processing, marks a fundamental paradigm shift in system requirements. Unlike…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-20 Moiz Arif , Avinash Maurya , Sudharshan Vazhkudai , Bogdan Nicolae

A major bottleneck in scenario-based Sample Average Approximation (SAA) for stochastic programming (SP) is the cost of solving an exact second-stage problem for every scenario, especially when each scenario contains an NP-hard combinatorial…

Optimization and Control · Mathematics 2026-05-12 Jingyi Zhao , Linxin Yang , Haohua Zhang , Qile He , Tian Ding

Autonomous driving in high-speed racing, as opposed to urban environments, presents significant challenges in scene understanding due to rapid changes in the track environment. Traditional sequential network approaches may struggle to meet…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Suwesh Prasad Sah

The expansion of context windows in large language models (LLMs) to multi-million tokens introduces severe memory and compute bottlenecks, particularly in managing the growing Key-Value (KV) cache. While Compute Express Link (CXL) enables…

Efficient and accurate prediction of Multiphysics evolution across diverse cell geometries is fundamental to the design, management and safety of lithium-ion batteries. However, existing computational frameworks struggle to capture the…

Computational Engineering, Finance, and Science · Computer Science 2026-03-19 Zhiwei Zhao , Changqing Liu , Jie Lin , Fan Yang , Yifan Zhang , Yan Jin , Yingguang Li
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