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Background: Photoplethysmography (PPG), increasingly available through wearable devices, provides a non-invasive means of monitoring human hemodynamics. In this study, we introduce artificial intelligence-derived photoplethysmography…

Signal Processing · Electrical Eng. & Systems 2025-09-26 Guangkun Nie , Qinghao Zhao , Gongzheng Tang , Yaxin Li , Shenda Hong

We present the findings of an experimental study whereby we correlate the changes in the morphology of the photoplethysmography (PPG) signal to healthy aging. Under this pretext, we estimate the biological age of a person as well as the age…

Photoplethysmography (PPG) is emerging as a crucial tool for monitoring human hemodynamics, with recent studies highlighting its potential in assessing vascular aging through deep learning. However, real-world age distributions are often…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Guangkun Nie , Qinghao Zhao , Gongzheng Tang , Jun Li , Shenda Hong

Photoplethysmography (PPG)-based foundation models are gaining traction due to the widespread use of PPG in biosignal monitoring and their potential to generalize across diverse health applications. In this paper, we introduce Pulse-PPG,…

Machine Learning · Computer Science 2025-07-25 Mithun Saha , Maxwell A. Xu , Wanting Mao , Sameer Neupane , James M. Rehg , Santosh Kumar

Photoplethysmography (PPG) is the leading non-invasive technique for monitoring biosignals and cardiovascular health, with widespread adoption in both clinical settings and consumer wearable devices. While machine learning models trained on…

Machine Learning · Computer Science 2025-02-06 Arvind Pillai , Dimitris Spathis , Fahim Kawsar , Mohammad Malekzadeh

Purpose: To develop an age prediction model which is interpretable and robust to demographic and technological variances in brain MRI scans. Materials and Methods: We propose a transformer-based architecture that leverages self-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Pengyu Kan , Craig Jones , Kenichi Oishi

Numerous studies have established that estimated brain age, as derived from statistical models trained on healthy populations, constitutes a valuable biomarker that is predictive of cognitive decline and various neurological diseases. In…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Xinyang Feng , Zachary C. Lipton , Jie Yang , Scott A. Small , Frank A. Provenzano

Photoplethysmography (PPG) is one of the most widely captured biosignals for clinical prediction tasks, yet PPG-based algorithms are typically trained on small-scale datasets of uncertain quality, which hinders meaningful algorithm…

Machine Learning · Computer Science 2026-03-24 Mohammad Moulaeifard , Philip J. Aston , Peter H. Charlton , Nils Strodthoff

The use of observed wearable sensor data (e.g., photoplethysmograms [PPG]) to infer health measures (e.g., glucose level or blood pressure) is a very active area of research. Such technology can have a significant impact on health…

Signal Processing · Electrical Eng. & Systems 2023-05-01 Suril Mehta , Nipun Kwatra , Mohit Jain , Daniel McDuff

Accurate extraction of heart rate from photoplethysmography (PPG) signals remains challenging due to motion artifacts and signal degradation. Although deep learning methods trained as a data-driven inference problem offer promising…

Signal Processing · Electrical Eng. & Systems 2024-10-21 Christodoulos Kechris , Jonathan Dan , Jose Miranda , David Atienza

In many developed countries, human life expectancy has doubled over the last 180 years from ~40 to ~80 years. Underlying this great advance is a change in how we age, yet our understanding of this change remains limited. Here we present a…

Quantitative Methods · Quantitative Biology 2018-03-28 J. A. Barthold Jones , U. W. Nash , J. Vieillefont , K. Christensen , D. Misevic , U. K. Steiner

Cardiovascular disease remains the leading cause of global mortality, yet scalable cardiac monitoring is hindered by the gap between diagnostic-rich ECG and ubiquitous wearable PPG. Bridging this gap requires representations that are…

Machine Learning · Computer Science 2026-05-12 Zhangdaihong Liu , Chang Liu , Fenglin Liu , Yixuan Chen , Yang Yang , David A. Clifton , Xiao Gu

The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age", which can be compared to an age norm to reflect the deviation from normal aging process. Here, we develop…

Cuffless blood pressure screening based on easily acquired photoplethysmography (PPG) signals offers a practical pathway toward scalable cardiovascular health assessment. Despite rapid progress, existing PPG-based blood pressure estimation…

Machine Learning · Computer Science 2026-02-05 Neville Mathew , Yidan Shen , Renjie Hu , Maham Rahimi , George Zouridakis

Cardiotocography (CTG) is a low-cost, non-invasive fetal health assessment technique used globally, especially in underdeveloped countries. However, it is currently mainly used to identify the fetus's current status (e.g., fetal acidosis or…

Signal Processing · Electrical Eng. & Systems 2025-09-19 Jinshuai Gu , Zenghui Lin , Jingying Ma , Jingyu Wang , Linyan Zhang , Rui Bai , Zelin Tu , Youyou Jiang , Donglin Xie , Yuxi Zhou , Guoli Liu , Shenda Hong

Current foundation model for photoplethysmography (PPG) signals is challenged by the intrinsic redundancy and noise of the signal. Standard masked modeling often yields trivial solutions while contrastive methods lack morphological…

Machine Learning · Computer Science 2026-01-30 Zongheng Guo , Tao Chen , Yang Jiao , Yi Pan , Xiao Hu , Manuela Ferrario

Cardiovascular diseases remain the leading global cause of mortality. Age is an important covariate whose effect is most easily investigated in a healthy cohort to properly distinguish the former from disease-related changes. Traditionally,…

Signal Processing · Electrical Eng. & Systems 2024-04-23 Gabriel Ott , Yannik Schaubelt , Juan Miguel Lopez Alcaraz , Wilhelm Haverkamp , Nils Strodthoff

Predicting an individual's aging trajectory is a central challenge in preventative medicine and bioinformatics. While machine learning models can predict chronological age from biomarkers, they often fail to capture the dynamic,…

Machine Learning · Computer Science 2025-08-14 Nazira Dunbayeva , Yulong Li , Yutong Xie , Imran Razzak

Existing age estimation methods treat each face as an independent sample, learning a global mapping from appearance to age. This ignores a well-documented phenomenon: individuals age at different rates due to genetics, lifestyle, and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Jakub Paplhám , Vojtěch Franc , Artem Moroz

The brain's white matter (WM) undergoes developmental and degenerative processes during the human lifespan. To investigate the relationship between WM anatomical regions and age, we study diffusion magnetic resonance imaging tractography…

Neurons and Cognition · Quantitative Biology 2023-07-06 Yuxiang Wei , Tengfei Xue , Yogesh Rathi , Nikos Makris , Fan Zhang , Lauren J. O'Donnell
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