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Medical AI, including clinical language models, vision-language models, and multimodal health record models, already summarizes notes, answers questions, and supports decisions. Their adaptation to new populations, specialties, or care…

Artificial Intelligence · Computer Science 2025-12-01 Michelle M. Li , Ben Y. Reis , Adam Rodman , Tianxi Cai , Noa Dagan , Ran D. Balicer , Joseph Loscalzo , Isaac S. Kohane , Marinka Zitnik

Domain generalization aims to learn a model with good generalization ability, that is, the learned model should not only perform well on several seen domains but also on unseen domains with different data distributions. State-of-the-art…

Machine Learning · Computer Science 2023-04-04 Boyang Lyu , Thuan Nguyen , Matthias Scheutz , Prakash Ishwar , Shuchin Aeron

The performance of predictive models in clinical settings often degrades when deployed in new hospitals due to distribution shifts. This paper presents a large-scale study of causality-inspired domain generalization on heterogeneous…

Applications · Statistics 2026-03-03 Malte Londschien , Manuel Burger , Gunnar Rätsch , Peter Bühlmann

Going beyond correlations, the understanding and identification of causal relationships in observational time series, an important subfield of Causal Discovery, poses a major challenge. The lack of access to a well-defined ground truth for…

Machine Learning · Statistics 2021-04-19 Andrew R. Lawrence , Marcus Kaiser , Rui Sampaio , Maksim Sipos

Domain generalization approaches aim to learn a domain invariant prediction model for unknown target domains from multiple training source domains with different distributions. Significant efforts have recently been committed to broad…

Computer Vision and Pattern Recognition · Computer Science 2021-08-23 Mohammad Mahfujur Rahman , Clinton Fookes , Sridha Sridharan

Causality has the potential to truly transform the way we solve a large number of real-world problems. Yet, so far, its potential largely remains to be unlocked as causality often requires crucial assumptions which cannot be tested in…

Machine Learning · Computer Science 2024-02-15 Jeroen Berrevoets , Krzysztof Kacprzyk , Zhaozhi Qian , Mihaela van der Schaar

Domain generalization (DG) aims to learn predictive models that can generalize to unseen domains. Most existing DG approaches focus on learning domain-invariant representations under the assumption of conditional distribution shift (i.e.,…

Machine Learning · Computer Science 2026-02-03 Jewon Yeom , Kyubyung Chae , Hyunggyu Lim , Yoonna Oh , Dongyoon Yang , Taesup Kim

The ability to learn and act in novel situations is still a prerogative of animate intelligence, as current machine learning methods mostly fail when moving beyond the standard i.i.d. setting. What is the reason for this discrepancy? Most…

Machine Learning · Computer Science 2018-12-04 Niki Kilbertus , Giambattista Parascandolo , Bernhard Schölkopf

Learning domain-invariant semantic representations is crucial for achieving domain generalization (DG), where a model is required to perform well on unseen target domains. One critical challenge is that standard training often results in…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Liang Chen , Yong Zhang , Yibing Song , Zhen Zhang , Lingqiao Liu

When predicting a target variable $Y$ from features $X$, the prediction $\hat{Y}$ can be performative: an agent might act on this prediction, affecting the value of $Y$ that we eventually observe. Performative predictions are deliberately…

Machine Learning · Computer Science 2024-04-09 Philip Boeken , Onno Zoeter , Joris M. Mooij

Machine learning strategies like multi-task learning, meta-learning, and transfer learning enable efficient adaptation of machine learning models to specific applications in healthcare, such as prediction of various diseases, by leveraging…

Machine Learning · Computer Science 2024-12-31 Sophie Wharrie , Lisa Eick , Lotta Mäkinen , Andrea Ganna , Samuel Kaski , FinnGen

Domain generalization (DG) is essentially an out-of-distribution problem, aiming to generalize the knowledge learned from multiple source domains to an unseen target domain. The mainstream is to leverage statistical models to model the…

Machine Learning · Computer Science 2022-03-29 Fangrui Lv , Jian Liang , Shuang Li , Bin Zang , Chi Harold Liu , Ziteng Wang , Di Liu

Cross-site generalizability in medical AI is fundamentally compromised by selection bias, a structural mechanism where patient demographics (e.g., age, severity) non-randomly dictate hospital assignment. Conventional Domain Generalization…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Shaojin Bai , Yuting Su , Weizhi Nie

Domain generalization algorithms use training data from multiple domains to learn models that generalize well to unseen domains. While recently proposed benchmarks demonstrate that most of the existing algorithms do not outperform simple…

Machine Learning · Computer Science 2021-11-30 Tigran Galstyan , Hrayr Harutyunyan , Hrant Khachatrian , Greg Ver Steeg , Aram Galstyan

Uncertainty quantification is central to many applications of causal machine learning, yet principled Bayesian inference for causal effects remains challenging. Standard Bayesian approaches typically require specifying a probabilistic model…

Machine Learning · Statistics 2026-03-04 Emil Javurek , Dennis Frauen , Yuxin Wang , Stefan Feuerriegel

Healthcare requires AI that is predictive, reliable, and data-efficient. However, recent generative models lack physical foundation and temporal reasoning required for clinical decision support. As scaling language models show diminishing…

Machine Learning · Computer Science 2025-11-21 Mohammad Areeb Qazi , Maryam Nadeem , Mohammad Yaqub

Estimating causal quantities traditionally relies on bespoke estimators tailored to specific assumptions. Recently proposed Causal Foundation Models (CFMs) promise a more unified approach by amortising causal discovery and inference in a…

Multi-domain recommendation leverages domain-general knowledge to improve recommendations across several domains. However, as platforms expand to dozens or hundreds of scenarios, training all domains in a unified model leads to performance…

Information Retrieval · Computer Science 2025-07-10 Huishi Luo , Yiqing Wu , Yiwen Chen , Fuzhen Zhuang , Deqing Wang

This paper reviews concepts, modeling approaches, and recent findings along a spectrum of different levels of abstraction of neural network models including generalization across (1) Samples, (2) Distributions, (3) Domains, (4) Tasks, (5)…

Machine Learning · Computer Science 2024-08-02 Chris Rohlfs

In Domain Generalization (DG) tasks, models are trained by using only training data from the source domains to achieve generalization on an unseen target domain, this will suffer from the distribution shift problem. So it's important to…

Computer Vision and Pattern Recognition · Computer Science 2023-02-14 Cheng Dai , Yingqiao Lin , Fan Li , Xiyao Li , Donglin Xie
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