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Identifying genes that display spatial patterns is critical to investigating expression interactions within a spatial context and further dissecting biological understanding of complex mechanistic functionality. Despite the increase in…

Methodology · Statistics 2025-10-06 Mingcong Wu , Yang Li , Shuangge Ma , Mengyun Wu

In text recognition, self-supervised pre-training emerges as a good solution to reduce dependence on expansive annotated real data. Previous studies primarily focus on local visual representation by leveraging mask image modeling or…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Zuan Gao , Yuxin Wang , Yadong Qu , Boqiang Zhang , Zixiao Wang , Jianjun Xu , Hongtao Xie

Medical image segmentation remains challenging in low-data regimes, where scarce annotations often yield poor generalization and ambiguous boundaries with missing fine structures. Recent self-supervised pretraining has improved…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Zhiquan Chen , Haitao Wang , Guowei Zou , Hejun Wu

Neural fields are a highly effective representation across visual computing. This work observes that fitting these fields is greatly improved by incorporating spatial stochasticity during training, and that this simple technique can replace…

Graphics · Computer Science 2025-05-28 Selena Ling , Merlin Nimier-David , Alec Jacobson , Nicholas Sharp

Whole slide images (WSIs) pose fundamental computational challenges due to their gigapixel resolution and the sparse distribution of informative regions. Existing approaches often treat image patches independently or reshape them in ways…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Weiyi Wu , Xingjian Diao , Chunhui Zhang , Chongyang Gao , Xinwen Xu , Siting Li , Jiang Gui

Quantitative characterization of cellular spatial organization is critical for understanding tumor progression and immune response. Recent advances in artificial intelligence (AI) enable large-scale segmentation and classification of nuclei…

The existing barely-supervised medical image segmentation (BSS) methods, adopting a registration-segmentation paradigm, aim to learn from data with very few annotations to mitigate the extreme label scarcity problem. However, this paradigm…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Junming Su , Zhiqiang Shen , Peng Cao , Jinzhu Yang , Osmar R. Zaiane

Vision transformers, with their ability to more efficiently model long-range context, have demonstrated impressive accuracy gains in several computer vision and medical image analysis tasks including segmentation. However, such methods need…

Image and Video Processing · Electrical Eng. & Systems 2022-09-27 Jue Jiang , Neelam Tyagi , Kathryn Tringale , Christopher Crane , Harini Veeraraghavan

Podocytes, specialized epithelial cells that envelop the glomerular capillaries, play a pivotal role in maintaining renal health. The current description and quantification of features on pathology slides are limited, prompting the need for…

Quantitative Methods · Quantitative Biology 2023-08-15 Jiayuan Chen , Yu Wang , Ruining Deng , Quan Liu , Can Cui , Tianyuan Yao , Yilin Liu , Jianyong Zhong , Agnes B. Fogo , Haichun Yang , Shilin Zhao , Yuankai Huo

Transcribing content from structural images, e.g., writing notes from music scores, is a challenging task as not only the content objects should be recognized, but the internal structure should also be preserved. Existing image recognition…

Machine Learning · Computer Science 2019-05-28 Yu Yin , Zhenya Huang , Enhong Chen , Qi Liu , Fuzheng Zhang , Xing Xie , Guoping Hu

Annotating medical imaging datasets is costly, so fine-tuning (or transfer learning) is the most effective method for digital pathology vision applications such as disease classification and semantic segmentation. However, due to texture…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Tushar Kataria , Beatrice Knudsen , Shireen Elhabian

Semantic segmentation of microscopic cell images using deep learning is an important technique, however, it requires a large number of images and ground truth labels for training. To address the above problem, we consider an efficient…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Sota Kato , Kazuhiro Hotta

Pretraining CNN models (i.e., UNet) through self-supervision has become a powerful approach to facilitate medical image segmentation under low annotation regimes. Recent contrastive learning methods encourage similar global representations…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Zhangsihao Yang , Mengwei Ren , Kaize Ding , Guido Gerig , Yalin Wang

Deep learning has shown strong potential in cancer classification from whole-slide images (WSIs), but the need for extensive expert annotations often limits its success. Annotation-free approaches, such as multiple instance learning (MIL)…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Willmer Rafell Quinones Robles , Sakonporn Noree , Jongwoo Kim , Young Sin Ko , Bryan Wong , Mun Yong Yi

Spatio-temporal representational learning has been widely adopted in various fields such as action recognition, video object segmentation, and action anticipation. Previous spatio-temporal representational learning approaches primarily…

Computer Vision and Pattern Recognition · Computer Science 2021-11-01 Xuefan Zha , Wentao Zhu , Tingxun Lv , Sen Yang , Ji Liu

"Is it possible to predict expression levels of different genes at a given spatial location in the routine histology image of a tumor section by modeling its stain absorption characteristics?" In this work, we propose a "stain-aware"…

Image and Video Processing · Electrical Eng. & Systems 2021-08-27 Muhammad Dawood , Kim Branson , Nasir M. Rajpoot , Fayyaz ul Amir Afsar Minhas

Spatial transcriptomics (ST) is an emerging technology that enables medical computer vision scientists to automatically interpret the molecular profiles underlying morphological features. Currently, however, most deep learning-based ST…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 Junchao Zhu , Ruining Deng , Tianyuan Yao , Juming Xiong , Chongyu Qu , Junlin Guo , Siqi Lu , Mengmeng Yin , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

In image segmentation, there is often more than one plausible solution for a given input. In medical imaging, for example, experts will often disagree about the exact location of object boundaries. Estimating this inherent uncertainty and…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Miguel Monteiro , Loïc Le Folgoc , Daniel Coelho de Castro , Nick Pawlowski , Bernardo Marques , Konstantinos Kamnitsas , Mark van der Wilk , Ben Glocker

Training segmentation models for medical images continues to be challenging due to the limited availability of data annotations. Segment Anything Model (SAM) is a foundation model that is intended to segment user-defined objects of interest…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Maciej A. Mazurowski , Haoyu Dong , Hanxue Gu , Jichen Yang , Nicholas Konz , Yixin Zhang

Recent advancements in spatial transcriptomics technologies allow researchers to simultaneously measure RNA expression levels for hundreds to thousands of genes while preserving spatial information within tissues, providing critical…

Methodology · Statistics 2025-07-31 Catherine Higgins , Jingyi Jessica Li , Michelle Carey