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BACKGROUND: Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition motifs located upstream of the coding region of the regulated…

Genomics · Quantitative Biology 2007-05-23 Davide Cora' , Ferdinando Di Cunto , Paolo Provero , Lorenzo Silengo , Michele Caselle

We examine the binding of transcription factors to DNA in terms of an information transfer problem. The input of the noisy channel is the biophysical signal of a factor bound to a DNA site, and the output is a distribution of probable DNA…

Genomics · Quantitative Biology 2015-08-07 Yonatan Savir Jacob Kagan , Tsvi Tlusty

Multi-label classification consists in classifying an instance into two or more classes simultaneously. It is a very challenging task present in many real-world applications, such as classification of biology, image, video, audio, and text.…

Machine Learning · Computer Science 2020-04-03 Thiago Zafalon Miranda , Diorge Brognara Sardinha , Márcio Porto Basgalupp , Yaochu Jin , Ricardo Cerri

A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these…

Molecular Networks · Quantitative Biology 2016-02-10 Thomas R. Sokolowski , Aleksandra M. Walczak , William Bialek , Gašper Tkačik

The collection and curation of large-scale medical datasets from multiple institutions is essential for training accurate deep learning models, but privacy concerns often hinder data sharing. Federated learning (FL) is a promising solution…

Computer Vision and Pattern Recognition · Computer Science 2023-01-12 Rui Yan , Liangqiong Qu , Qingyue Wei , Shih-Cheng Huang , Liyue Shen , Daniel Rubin , Lei Xing , Yuyin Zhou

In multi-label classification, the main focus has been to develop ways of learning the underlying dependencies between labels, and to take advantage of this at classification time. Developing better feature-space representations has been…

Machine Learning · Computer Science 2015-02-23 Jesse Read , Fernando Perez-Cruz

While deep convolutional neural networks (CNNs) have shown a great success in single-label image classification, it is important to note that real world images generally contain multiple labels, which could correspond to different objects,…

Computer Vision and Pattern Recognition · Computer Science 2016-04-18 Jiang Wang , Yi Yang , Junhua Mao , Zhiheng Huang , Chang Huang , Wei Xu

Connectivity networks have recently become widely used in biology due to increasing amounts of information on the physical and functional links between individual proteins. This connectivity data provides valuable material for expanding our…

Genomics · Quantitative Biology 2013-02-15 O. V. Valba , S. K. Nechaev , O. Vasieva

Time-frequency (TF) domain dual-path models achieve high-fidelity speech separation. While some previous state-of-the-art (SoTA) models rely on RNNs, this reliance means they lack the parallelizability, scalability, and versatility of…

Audio and Speech Processing · Electrical Eng. & Systems 2024-08-08 Kohei Saijo , Gordon Wichern , François G. Germain , Zexu Pan , Jonathan Le Roux

We consider a real-world scenario in which a newly-established pilot project needs to make inferences for newly-collected data with the help of other parties under privacy protection policies. Current federated learning (FL) paradigms are…

Machine Learning · Computer Science 2023-05-09 Xin-Chun Li , Yang Yang , De-Chuan Zhan

Domain adaptation aims at training a classifier in one dataset and applying it to a related but not identical dataset. One successfully used framework of domain adaptation is to learn a transformation to match both the distribution of the…

Computer Vision and Pattern Recognition · Computer Science 2015-03-03 Xu Zhang , Felix Xinnan Yu , Shih-Fu Chang , Shengjin Wang

Dynamic facial expression recognition (DFER) aims to identify emotional states by modeling the temporal changes in facial movements across video sequences. A key challenge in DFER is the many-to-one labeling problem, where a video composed…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Gunho Jung , Heejo Kong , Seong-Whan Lee

This paper presents a Tri-branch Neural Fusion (TNF) approach designed for classifying multimodal medical images and tabular data. It also introduces two solutions to address the challenge of label inconsistency in multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Tong Zheng , Shusaku Sone , Yoshitaka Ushiku , Yuki Oba , Jiaxin Ma

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Biomolecules · Quantitative Biology 2020-12-17 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

The application of deep learning methods, particularly foundation models, in biological research has surged in recent years. These models can be text-based or trained on underlying biological data, especially omics data of various types.…

Artificial Intelligence · Computer Science 2024-12-06 Yoav Kan-Tor , Michael Morris Danziger , Eden Zohar , Matan Ninio , Yishai Shimoni

With the continue development of Convolutional Neural Networks (CNNs), there is a growing concern regarding representations that they encode internally. Analyzing these internal representations is referred to as model interpretation. While…

Computer Vision and Pattern Recognition · Computer Science 2023-05-18 Hamed Behzadi-Khormouji , José Oramas

Genetic variation affecting gene regulation is a central driver of phenotypic differences between individuals and can be used to uncover how biological processes are organized in a cell. Although detecting cis-eQTLs is now routine,…

Multi-label node classification is an important yet under-explored domain in graph mining as many real-world nodes belong to multiple categories rather than just a single one. Although a few efforts have been made by utilizing Graph…

Machine Learning · Computer Science 2025-06-18 Yuanchen Bei , Weizhi Chen , Hao Chen , Sheng Zhou , Carl Yang , Jiapei Fan , Longtao Huang , Jiajun Bu

Personalized federated learning algorithms have shown promising results in adapting models to various distribution shifts. However, most of these methods require labeled data on testing clients for personalization, which is usually…

Machine Learning · Computer Science 2023-10-31 Wenxuan Bao , Tianxin Wei , Haohan Wang , Jingrui He

Extreme multi-label text classification (XMTC) is the task of tagging each document with the relevant labels from a very large space of predefined categories. Recently, large pre-trained Transformer models have made significant performance…

Computation and Language · Computer Science 2022-04-05 Ruohong Zhang , Yau-Shian Wang , Yiming Yang , Tom Vu , Likun Lei
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