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Gene regulation is an important fundamental biological process. The regulation of gene expression is managed through a variety of methods including epigenetic processes (e.g., DNA methylation). Understanding the role of epigenetic changes…

Molecular Networks · Quantitative Biology 2021-06-01 James Brunner , Jacob Kim , Timothy Downing , Eric Mjolsness , Kord M. Kober

Generating realistic training data for supervised learning remains a significant challenge in artificial intelligence, particularly in domains where large, expert-labeled datasets are scarce or costly to obtain. This is especially true for…

Machine Learning · Computer Science 2026-03-20 Yakir Yehuda , Kira Radinsky

In medical fields, text classification is one of the most important tasks that can significantly reduce human workload through structured information digitization and intelligent decision support. Despite the popularity of learning-based…

Computation and Language · Computer Science 2020-12-15 J Liu , R Bai , Z Lu , P Ge , D Liu , Uwe Aickelin

Generative Adversarial Networks (GANs) are popular tools for generative modeling. The dynamics of their adversarial learning give rise to convergence pathologies during training such as mode and discriminator collapse. In machine learning,…

Artificial Intelligence · Computer Science 2020-08-04 Jamal Toutouh , Erik Hemberg , Una-May O'Reilly

Choosing the most adequate kernel is crucial in many Machine Learning applications. Gaussian Process is a state-of-the-art technique for regression and classification that heavily relies on a kernel function. However, in the Gaussian…

Machine Learning · Computer Science 2019-10-15 Ibai Roman , Roberto Santana , Alexander Mendiburu , Jose A. Lozano

Spatial transcriptomics (ST) enables spot-level in situ expression profiling, but its high cost and limited throughput motivate predicting expression directly from HE-stained histology. Recent advances explore using score- or flow-based…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Donghai Fang , Yongheng Li , Zhen Wang , Yuansong Zeng , Wenwen Min

Regular expression is important for many natural language processing tasks especially when used to deal with unstructured and semi-structured data. This work focuses on automatically generating regular expressions and proposes a novel…

Neural and Evolutionary Computing · Computer Science 2020-06-25 Desheng Wang , Jiawei Liu , Xiang Qi , Baolin Sun , Peng Zhang

The data scarcity problem in Electroencephalography (EEG) based affective computing results into difficulty in building an effective model with high accuracy and stability using machine learning algorithms especially deep learning models.…

Machine Learning · Computer Science 2021-09-09 Zhi Zhang , Sheng-hua Zhong , Yan Liu

Cell growth and gene expression, essential elements of all living systems, have long been the focus of biophysical interrogation. Advances in single-cell methods have invigorated theoretical studies into these processes. However, until…

Subcellular Processes · Quantitative Biology 2023-11-22 Ido Golding , Ariel Amir

Generative adversarial networks (GANs) are emerging machine learning models for generating synthesized data similar to real data by jointly training a generator and a discriminator. In many applications, data and computational resources are…

Machine Learning · Computer Science 2021-07-20 Jinke Ren , Chonghe Liu , Guanding Yu , Dongning Guo

Generating novel and functional protein sequences is critical to a wide range of applications in biology. Recent advancements in conditional diffusion models have shown impressive empirical performance in protein generation tasks. However,…

Machine Learning · Computer Science 2025-12-04 Zinan Ling , Yi Shi , Brett McKinney , Da Yan , Yang Zhou , Bo Hui

This paper presents a novel paradigm in simulation-based engineering sciences by introducing a new framework called Generative Parametric Design (GPD). The GPD framework enables the generation of new designs along with their corresponding…

Computational Engineering, Finance, and Science · Computer Science 2025-12-15 Mohammed El Fallaki Idrissi , Jad Mounayer , Sebastian Rodriguez , Fodil Meraghni , Francisco Chinesta

Deep generative models are increasingly used to gain insights in the geospatial data domain, e.g., for climate data. However, most existing approaches work with temporal snapshots or assume 1D time-series; few are able to capture…

Computer Vision and Pattern Recognition · Computer Science 2021-04-27 Konstantin Klemmer , Sudipan Saha , Matthias Kahl , Tianlin Xu , Xiao Xiang Zhu

Imbalanced classification remains a pervasive challenge in machine learning, particularly when minority samples are too scarce to provide a robust discriminative boundary. In such extreme scenarios, conventional models often suffer from…

Machine Learning · Computer Science 2026-04-29 Hongfei Wu , Ruijian Han , Yancheng Yuan

Deep generative models are powerful tools that have produced impressive results in recent years. These advances have been for the most part empirically driven, making it essential that we use high quality evaluation metrics. In this paper,…

Machine Learning · Statistics 2018-06-22 Shane Barratt , Rishi Sharma

In this paper, we propose a general framework for testing the conditional distribution equality in a two-sample problem, which is most relevant to covariate shift and causal discovery. Our framework is built on neural network-based…

Machine Learning · Computer Science 2025-11-27 Siming Zheng , Tong Wang , Meifang Lan , Yuanyuan Lin

Synthetic data is becoming an increasingly promising technology, and successful applications can improve privacy, fairness, and data democratization. While there are many methods for generating synthetic tabular data, the task remains…

Machine Learning · Computer Science 2023-02-27 Alexander Norcliffe , Bogdan Cebere , Fergus Imrie , Pietro Lio , Mihaela van der Schaar

Lots of bio-inspired research works have been conducted in self-adaptive software. They have focused on the external behavior of biological entities without their genetic material that causes this behavior and constitutes the challenge this…

Software Engineering · Computer Science 2019-04-30 Enas Nafar , Said Ghoul

Multi Expression Programming (MEP) is a Genetic Programming variant that uses a linear representation of chromosomes. MEP individuals are strings of genes encoding complex computer programs. When MEP individuals encode expressions, their…

Neural and Evolutionary Computing · Computer Science 2021-10-04 Mihai Oltean

Documents are often used for knowledge sharing and preservation in business and science, within which are tables that capture most of the critical data. Unfortunately, most documents are stored and distributed as PDF or scanned images,…

Computer Vision and Pattern Recognition · Computer Science 2020-12-03 Xinyi Zheng , Doug Burdick , Lucian Popa , Xu Zhong , Nancy Xin Ru Wang