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Attribute extrapolation in sample generation is challenging for deep neural networks operating beyond the training distribution. We formulate a new task for extrapolation in sequence generation, focusing on natural language and proteins,…

Machine Learning · Computer Science 2021-10-27 Alvin Chan , Ali Madani , Ben Krause , Nikhil Naik

Function in natural systems arises from one-dimensional sequences forming three-dimensional structures with specific properties. However, current generative models suffer from critical limitations: training objectives seldom target function…

Search-Augmented Generative Engines (SAGE) have emerged as a new paradigm for information access, bridging web-scale retrieval with generative capabilities to deliver synthesized answers. This shift has fundamentally reshaped how web…

Information Retrieval · Computer Science 2026-02-13 Sunghwan Kim , Wooseok Jeong , Serin Kim , Sangam Lee , Dongha Lee

Generating realistic graph-structured data is challenging due to discrete connectivity, varying graph sizes, and class-specific structural patterns. Recent Generative Adversarial Networks (GAN)-based graph generation methods improve edge…

Machine Learning · Computer Science 2026-05-29 James Sargant , Seyedeh Ava Razi Razavi , Renata Dividino , Sheridan Houghten

In recent years, significant progress has been made in both image generation and generated image detection. Despite their rapid, yet largely independent, development, these two fields have evolved distinct architectural paradigms: the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Yanran Zhang , Wenzhao Zheng , Yifei Li , Bingyao Yu , Yu Zheng , Lei Chen , Jiwen Lu , Jie Zhou

Grammar Error Correction(GEC) mainly relies on the availability of high quality of large amount of synthetic parallel data of grammatically correct and erroneous sentence pairs. The quality of the synthetic data is evaluated on how well the…

Computation and Language · Computer Science 2022-11-01 Vanya Bannihatti Kumar

High-throughput sequencing of RNA transcripts (RNA-seq) has become the method of choice for detection of differential expression (DE). Concurrent with the growing popularity of this technology there has been a significant research effort…

The true distribution parameterizations of commonly used image datasets are inaccessible. Rather than designing metrics for feature spaces with unknown characteristics, we propose to measure GAN performance by evaluating on explicitly…

Machine Learning · Computer Science 2018-12-31 Shayne O'Brien , Matt Groh , Abhimanyu Dubey

Multi-modal generative document parsing systems challenge traditional evaluation: unlike deterministic OCR or layout models, they often produce semantically correct yet structurally divergent outputs. Conventional metrics-CER, WER, IoU, or…

Computation and Language · Computer Science 2025-09-25 Renyu Li , Antonio Jimeno Yepes , Yao You , Kamil Pluciński , Maximilian Operlejn , Crag Wolfe

Edge detection is typically viewed as a pixel-level classification problem mainly addressed by discriminative methods. Recently, generative edge detection methods, especially diffusion model based solutions, are initialized in the edge…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Caixia Zhou , Yaping Huang , Mochu Xiang , Jiahui Ren , Haibin Ling , Jing Zhang

Genome-wide association studies generate very large datasets that require scalable analysis algorithms. In this report we describe the GEDI software package, which implements efficient algorithms for performing several common tasks in the…

Data Structures and Algorithms · Computer Science 2016-09-08 Justin Kennedy , Ion I. Mandoiu , Bogdan Pasaniuc

We conduct a scoping review of existing approaches for synthetic EHR data generation, and benchmark major methods with proposed open-source software to offer recommendations for practitioners. We search three academic databases for our…

Machine Learning · Computer Science 2025-06-05 Xingran Chen , Zhenke Wu , Xu Shi , Hyunghoon Cho , Bhramar Mukherjee

Text-to-image generation aims at generating realistic images which are semantically consistent with the given text. Previous works mainly adopt the multi-stage architecture by stacking generator-discriminator pairs to engage multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Mengqi Huang , Zhendong Mao , Penghui Wang , Quan Wang , Yongdong Zhang

Identifying differentially expressed (DE) genes associated with a sample characteristic is the primary objective of many microarray studies. As more and more studies are carried out with observational rather than well controlled…

Applications · Statistics 2012-07-02 Xi Kathy Zhou , Fei Liu , Andrew J. Dannenberg

Genetic Gaussian network of multiple phenotypes constructed through the genetic correlation matrix is informative for understanding their biological dependencies. However, its interpretation may be challenging because the estimated genetic…

Methodology · Statistics 2024-12-31 Yihe Yang , Noah Lorincz-Comi , Xiaofeng Zhu

Current evaluation practices in speech-driven gesture generation lack standardisation and focus on aspects that are easy to measure over aspects that actually matter. This leads to a situation where it is impossible to know what is the…

By integrating heterogeneous functional genomic datasets, we have developed a new framework for detecting combinatorial control of gene expression, which includes estimating transcription factor activities using a singular value…

Quantitative Methods · Quantitative Biology 2010-10-07 Junbai Wang

Electrocardiogram (ECG) datasets tend to be highly imbalanced due to the scarcity of abnormal cases. Additionally, the use of real patients' ECGs is highly regulated due to privacy issues. Therefore, there is always a need for more ECG…

Machine Learning · Computer Science 2022-08-25 Edmond Adib , Fatemeh Afghah , John J. Prevost

Generative Adversarial Networks (GANs) are proficient at generating synthetic data but continue to suffer from mode collapse, where the generator produces a narrow range of outputs that fool the discriminator but fail to capture the full…

Machine Learning · Computer Science 2025-11-03 Mahsa Valizadeh , Rui Tuo , James Caverlee

Over the years, genetic programming (GP) has evolved, with many proposed variations, especially in how they represent a solution. Being essentially a program synthesis algorithm, it is capable of tackling multiple problem domains. Current…

Neural and Evolutionary Computing · Computer Science 2025-04-15 Roman Kalkreuth , Fabricio Olivetti de França , Julian Dierkes , Marie Anastacio , Anja Jankovic , Zdenek Vasicek , Holger Hoos