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Multi-pulse magnetic resonance imaging (MRI) is widely utilized for clinical practice such as Alzheimer's disease diagnosis. To train a robust model for multi-pulse MRI classification, it requires large and diverse data from various medical…

Machine Learning · Computer Science 2025-10-21 Ludi Li , Junbin Mao , Hanhe Lin , Xu Tian , Fang-Xiang Wu , Jin Liu

In medical image analysis, Federated Learning (FL) stands out as a key technology that enables privacy-preserved, decentralized data processing, crucial for handling sensitive medical data. Currently, most FL models employ random…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Ming Li , Guang Yang

Federated learning (FL) is a decentralized machine learning paradigm in which multiple clients collaboratively train a shared model without sharing their local private data. However, real-world applications of FL frequently encounter…

Machine Learning · Computer Science 2025-08-14 Zhekai Zhou , Shudong Liu , Zhaokun Zhou , Yang Liu , Qiang Yang , Yuesheng Zhu , Guibo Luo

Weakly supervised instance labeling using only image-level labels, in lieu of expensive fine-grained pixel annotations, is crucial in several applications including medical image analysis. In contrast to conventional instance segmentation…

Computer Vision and Pattern Recognition · Computer Science 2019-07-31 Jayaraman J. Thiagarajan , Satyananda Kashyap , Alexandros Karagyris

Medical image segmentation under federated learning (FL) is a promising direction by allowing multiple clinical sites to collaboratively learn a global model without centralizing datasets. However, using a single model to adapt to various…

Computer Vision and Pattern Recognition · Computer Science 2022-07-12 Jiacheng Wang , Yueming Jin , Liansheng Wang

In computational pathology, weak supervision has become the standard for deep learning due to the gigapixel scale of WSIs and the scarcity of pixel-level annotations, with Multiple Instance Learning (MIL) established as the principal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Andreas Lolos , Theofilos Christodoulou , Aris L. Moustakas , Stergios Christodoulidis , Maria Vakalopoulou

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

In the field of whole slide image (WSI) classification, multiple instance learning (MIL) serves as a promising approach, commonly decoupled into feature extraction and aggregation. In this paradigm, our observation reveals that…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Xuenian Wang , Shanshan Shi , Renao Yan , Qiehe Sun , Lianghui Zhu , Tian Guan , Yonghong He

Foundation models have recently gained tremendous popularity in medical image analysis. State-of-the-art methods leverage either paired image-text data via vision-language pre-training or unpaired image data via self-supervised pre-training…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Lei Zhu , Jun Zhou , Rick Siow Mong Goh , Yong Liu

Foundation models like ChatGPT and Sora that are trained on a huge scale of data have made a revolutionary social impact. However, it is extremely challenging for sensors in many different fields to collect similar scales of natural images…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Chenyang Lei , Liyi Chen , Jun Cen , Xiao Chen , Zhen Lei , Felix Heide , Qifeng Chen , Zhaoxiang Zhang

Contrastive Language-Image Pre-training (CLIP) demonstrates strong potential in medical image analysis but requires substantial data and computational resources. Due to these restrictions, existing CLIP applications in medical imaging focus…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Yuexi Du , John Onofrey , Nicha C. Dvornek

We propose a new formulation of Multiple-Instance Learning (MIL). In typical MIL settings, a unit of data is given as a set of instances called a bag and the goal is to find a good classifier of bags based on similarity from a single or…

Machine Learning · Computer Science 2018-12-11 Daiki Suehiro , Kohei Hatano , Eiji Takimoto , Shuji Yamamoto , Kenichi Bannai , Akiko Takeda

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Multiple instance learning (MIL) has been widely used for representing whole-slide pathology images. However, spatial, semantic, and decision entanglements among instances limit its representation and interpretability. To address these…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Chentao Li , Behzad Bozorgtabar , Yifang Ping , Pan Huang , Jing Qin

In medical contexts, the imbalanced data distribution in long-tailed datasets, due to scarce labels for rare diseases, greatly impairs the diagnostic accuracy of deep learning models. Recent multimodal text-image supervised foundation…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Sirui Li , Li Lin , Yijin Huang , Pujin Cheng , Xiaoying Tang

The Forward-Forward (FF) algorithm presents a compelling, bio-inspired alternative to backpropagation. However, while efficient in training, it has a computationally prohibitive inference process that requires a separate forward pass for…

Machine Learning · Computer Science 2026-05-04 Shalini Sarode , Brian Moser , Joachim Folz , Federico Raue , Tobias Nauen , Stanislav Frolov , Andreas Dengel

Multi-instance learning (MIL) is an effective paradigm for whole-slide pathological images (WSIs) classification to handle the gigapixel resolution and slide-level label. Prevailing MIL methods primarily focus on improving the feature…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Tiancheng Lin , Zhimiao Yu , Hongyu Hu , Yi Xu , Chang Wen Chen

Multimodal medical analysis combining image and tabular data has gained increasing attention. However, effective fusion remains challenging due to cross-modal discrepancies in feature dimensions and modality contributions, as well as the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Congjing Yu , Jing Ye , Yang Liu , Xiaodong Zhang , Zhiyong Zhang

Cancer diagnosis has greatly benefited from the integration of whole-slide images (WSIs) with multiple instance learning (MIL), enabling high-resolution analysis of tissue morphology. Graph-based MIL (GNN-MIL) approaches have emerged as…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Jongwoo Kim , Bryan Wong , Huazhu Fu , Willmer Rafell Quiñones , Youngsin Ko , Mun Yong Yi

Multiple Instance Learning (MIL) is the predominant framework for classifying gigapixel whole-slide images in computational pathology. MIL follows a sequence of 1) extracting patch features, 2) applying a linear layer to obtain…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Daniel Shao , Joel Runevic , Richard J. Chen , Drew F. K. Williamson , Ahrong Kim , Andrew H. Song , Faisal Mahmood