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Scientific reasoning, the process through which humans apply logic, evidence, and critical thinking to explore and interpret scientific phenomena, is essential in advancing knowledge reasoning across diverse fields. However, despite…

Computation and Language · Computer Science 2026-04-21 Yibo Yan , Shen Wang , Jiahao Huo , Jingheng Ye , Zhendong Chu , Xuming Hu , Philip S. Yu , Carla Gomes , Bart Selman , Qingsong Wen

We introduce CODS (Computational Optimization in Design Space), a theoretical model that frames computational design as a constrained optimization problem over a structured, multi-dimensional design space. Unlike existing methods that rely…

Human-Computer Interaction · Computer Science 2025-06-24 Nan Cao , Xiaoyu Qi , Chuer Chen , Xiaoke Yan

In the field of chemical engineering, traditional data-processing and prediction methods face significant challenges. Machine-learning and large-language models (LLMs) also have their respective limitations. This paper explores the…

Machine Learning · Computer Science 2025-02-19 Tianhang Zhou , Yingchun Niu , Xingying Lan , Chunming Xu

Although perception systems have made remarkable advancements in recent years, they still rely on explicit human instruction or pre-defined categories to identify the target objects before executing visual recognition tasks. Such systems…

Computer Vision and Pattern Recognition · Computer Science 2024-05-02 Xin Lai , Zhuotao Tian , Yukang Chen , Yanwei Li , Yuhui Yuan , Shu Liu , Jiaya Jia

Large language models (LLMs) have large potential for molecular optimization, as they can gather external chemistry tools and enable collaborative interactions to iteratively refine molecular candidates. However, this potential remains…

Artificial Intelligence · Computer Science 2025-05-28 Hyomin Kim , Yunhui Jang , Sungsoo Ahn

Large language models (LLMs) hold considerable potential for advancing scientific discovery, yet systematic assessment of their dynamic reasoning in real-world research remains limited. Current scientific evaluation benchmarks predominantly…

Computation and Language · Computer Science 2026-03-27 Taolin Han , Shuang Wu , Jinghang Wang , Yuhao Zhou , Renquan Lv , Bing Zhao , Wei Hu

The rapid advancements in large Language models (LLMs) have significantly enhanced their reasoning capabilities, driven by various strategies such as multi-agent collaboration. However, unlike the well-established performance improvements…

Artificial Intelligence · Computer Science 2026-04-23 Zihan Chen , Song Wang , Zhen Tan , Xingbo Fu , Zhenyu Lei , Peng Wang , Huan Liu , Cong Shen , Jundong Li

Scientific problem solving poses unique challenges for LLMs, requiring both deep domain knowledge and the ability to apply such knowledge through complex reasoning. While automated scientific reasoners hold great promise for assisting human…

Computation and Language · Computer Science 2026-05-29 Alan Li , Yixin Liu , Arpan Sarkar , Doug Downey , Arman Cohan

Recent advances in large language models (LLMs) have enabled molecular reasoning for property prediction. However, toxicity arises from complex biological mechanisms beyond chemical structure, necessitating mechanistic reasoning for…

Quantitative Methods · Quantitative Biology 2026-04-09 Jueon Park , Wonjune Jang , Chanhwi Kim , Yein Park , Jaewoo Kang

Convincing someone of the truth value of a premise requires understanding and articulating the core logical structure of the argument which proves or disproves the premise. Understanding the logical structure of an argument refers to…

Computation and Language · Computer Science 2025-08-21 Krunal Shah , Dan Roth

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Neurosymbolic AI is an emerging compositional paradigm that fuses neural learning with symbolic reasoning to enhance the transparency, interpretability, and trustworthiness of AI. It also exhibits higher data efficiency making it promising…

Hardware Architecture · Computer Science 2025-03-18 Zishen Wan , Hanchen Yang , Ritik Raj , Che-Kai Liu , Ananda Samajdar , Arijit Raychowdhury , Tushar Krishna

Large Language Models (LLMs) are increasingly being used in education, yet their correctness alone does not capture the quality, reliability, or pedagogical validity of their problem-solving behavior, especially in mathematics, where…

Computers and Society · Computer Science 2025-10-22 Sagnik Dakshit , Sushmita Sinha Roy

Chain-of-Thought (CoT) prompting has been used to enhance the reasoning capability of LLMs. However, its reliability in security-sensitive analytical tasks remains insufficiently examined, particularly under structured human evaluation.…

Cryptography and Security · Computer Science 2026-04-07 Jiling Zhou , Aisvarya Adeseye , Seppo Virtanen , Antti Hakkala , Jouni Isoaho

The automation of chemical research through self-driving laboratories (SDLs) promises to accelerate scientific discovery, yet the reliability and granular performance of the underlying AI agents remain critical, under-examined challenges.…

Artificial Intelligence · Computer Science 2025-10-01 Gihan Panapitiya , Emily Saldanha , Heather Job , Olivia Hess

Recent advancements in large language models have showcased their remarkable generalizability across various domains. However, their reasoning abilities still have significant room for improvement, especially when confronted with scenarios…

Computation and Language · Computer Science 2024-03-27 Xufeng Zhao , Mengdi Li , Wenhao Lu , Cornelius Weber , Jae Hee Lee , Kun Chu , Stefan Wermter

Large language models (LLMs) have demonstrated broad utility across molecular domains, spanning drug discovery and materials design. Analyzing LLMs' latent representations is crucial for elucidating their underlying mechanisms, improving…

Machine Learning · Computer Science 2026-02-03 Zhuoran Li , Xu Sun , Wanyu Lin , Jiannong Cao

With the emergence of advanced reasoning models like OpenAI o3 and DeepSeek-R1, large language models (LLMs) have demonstrated remarkable reasoning capabilities. However, their ability to perform rigorous logical reasoning remains an open…

Artificial Intelligence · Computer Science 2025-02-14 Hanmeng Liu , Zhizhang Fu , Mengru Ding , Ruoxi Ning , Chaoli Zhang , Xiaozhang Liu , Yue Zhang

Resolving complex information needs that come with multiple constraints should consider enforcing the logical operators encoded in the query (i.e., conjunction, disjunction, negation) on the candidate answer set. Current retrieval systems…

Information Retrieval · Computer Science 2026-02-02 Mohanna Hoveyda , Jelle Piepenbrock , Arjen P de Vries , Maarten de Rijke , Faegheh Hasibi

Solving computer-aided synthesis planning is essential for enabling fully automated, robot-assisted synthesis workflows and improving the efficiency of drug discovery. A key challenge, however, is bridging the gap between computational…