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In this study, we expand upon the FLIP benchmark-designed for evaluating protein fitness prediction models in small, specialized prediction tasks-by assessing the performance of state-of-the-art large protein language models, including…

Machine Learning · Computer Science 2025-01-31 Manuel F. Mollon , Joaquin Gonzalez-Rodriguez , Alicia Lozano-Diez , Daniel Ramos , Doroteo T. Toledano

Designing experiments and result interpretations are core scientific competencies, particularly in biology, where researchers perturb complex systems to uncover the underlying systems. Recent efforts to evaluate the scientific capabilities…

Predicting the fitness impact of mutations is central to protein engineering but constrained by limited assays relative to the size of sequence space. Protein language models (pLMs) trained with masked language modeling (MLM) exhibit strong…

Machine Learning · Computer Science 2026-04-14 Jigang Fan , Xiaoran Jiao , Shengdong Lin , Zhanming Liang , Weian Mao , Chenchen Jing , Hao Chen , Chunhua Shen

With the ever-increasing popularity of pretrained Video-Language Models (VidLMs), there is a pressing need to develop robust evaluation methodologies that delve deeper into their visio-linguistic capabilities. To address this challenge, we…

3D graphics editing is crucial in applications like movie production and game design, yet it remains a time-consuming process that demands highly specialized domain expertise. Automating this process is challenging because graphical editing…

Graphics · Computer Science 2025-04-03 Yunqi Gu , Ian Huang , Jihyeon Je , Guandao Yang , Leonidas Guibas

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Oriel Perets , Michal Linial , Nadav Rappoport

Protein-specific large language models (Protein LLMs) are revolutionizing protein science by enabling more efficient protein structure prediction, function annotation, and design. While existing surveys focus on specific aspects or…

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

Machine Learning · Computer Science 2025-05-27 Hazem Alsamkary , Mohamed Elshaffei , Mohamed Elkerdawy , Ahmed Elnaggar

Although large visual-language models (LVLMs) have demonstrated strong performance in multimodal tasks, errors may occasionally arise due to biases during the reasoning process. Recently, reward models (RMs) have become increasingly pivotal…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Jiacheng Ruan , Wenzhen Yuan , Xian Gao , Ye Guo , Daoxin Zhang , Zhe Xu , Yao Hu , Ting Liu , Yuzhuo Fu

The biomedical domain has sparked a significant interest in the field of Natural Language Processing (NLP), which has seen substantial advancements with pre-trained language models (PLMs). However, comparing these models has proven…

Brain tumor diagnosis is largely dependent on Magnetic Resonance Imaging (MRI) evaluation, which requires radiologists to synthesize thousands of images across multiple 3D sequences and longitudinal studies. This process requires advanced…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Shiv Ghosh , Junayd Lateef , Chih-Hua Liu , Yannan Yu , Andreas M. Rauschecker , Madhumita Sushil

Proteins are fundamental to biology, executing diverse functions through complex physicochemical interactions, and they hold transformative potential across medicine, materials science, and environmental applications. Protein Language…

Biomolecules · Quantitative Biology 2025-06-11 Logan Hallee , Nikolaos Rafailidis , David B. Bichara , Jason P. Gleghorn

Evaluating vision-language models (VLMs) in scientific domains like mathematics and physics poses unique challenges that go far beyond predicting final answers. These domains demand conceptual understanding, symbolic reasoning, and…

Artificial Intelligence · Computer Science 2025-12-08 Shima Imani , Seungwhan Moon , Adel Ahmadyan , Lu Zhang , Kirmani Ahmed , Babak Damavandi

Current vision-language models (VLMs) in medicine are primarily designed for categorical question answering (e.g., "Is this normal or abnormal?") or qualitative descriptive tasks. However, clinical decision-making often relies on…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Yongcheng Yao , Yongshuo Zong , Raman Dutt , Yongxin Yang , Sotirios A Tsaftaris , Timothy Hospedales

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

We explore optimally training protein language models, an area of significant interest in biological research where guidance on best practices is limited. Most models are trained with extensive compute resources until performance gains…

Machine Learning · Computer Science 2024-11-05 Xingyi Cheng , Bo Chen , Pan Li , Jing Gong , Jie Tang , Le Song

Understanding the world and explaining it with scientific theories is a central aspiration of artificial intelligence research. Proposing theories, designing experiments to test them, and then revising them based on data are fundamental to…

Machine Learning · Computer Science 2025-10-16 Kanishk Gandhi , Michael Y. Li , Lyle Goodyear , Agam Bhatia , Louise Li , Aditi Bhaskar , Mohammed Zaman , Noah D. Goodman

Human age estimation from facial images represents a challenging computer vision task with significant applications in biometrics, healthcare, and human-computer interaction. While traditional deep learning approaches require extensive…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Rakib Hossain Sajib , Md Kishor Morol , Rajan Das Gupta , Mohammad Sakib Mahmood , Shuvra Smaran Das

Vision language models (VLM) have demonstrated remarkable performance across various downstream tasks. However, understanding fine-grained visual-linguistic concepts, such as attributes and inter-object relationships, remains a significant…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Wujian Peng , Sicheng Xie , Zuyao You , Shiyi Lan , Zuxuan Wu

Significant research efforts have been made to scale and improve vision-language model (VLM) training approaches. Yet, with an ever-growing number of benchmarks, researchers are tasked with the heavy burden of implementing each protocol,…

Computer Vision and Pattern Recognition · Computer Science 2024-08-12 Haider Al-Tahan , Quentin Garrido , Randall Balestriero , Diane Bouchacourt , Caner Hazirbas , Mark Ibrahim