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This paper has two contributions. First, we propose a novel coded matrix multiplication technique called Generalized PolyDot codes that advances on existing methods for coded matrix multiplication under storage and communication…

Information Theory · Computer Science 2018-11-28 Sanghamitra Dutta , Ziqian Bai , Haewon Jeong , Tze Meng Low , Pulkit Grover

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

This paper studies deep neural networks for solving extremely large linear systems arising from highdimensional problems. Because of the curse of dimensionality, it is expensive to store both the solution and right-hand side vector in such…

Numerical Analysis · Mathematics 2023-03-07 Yiqi Gu , Michael K. Ng

Determining the weight distribution of a linear code is a classical and fundamental topic in coding theory that has been extensively investigated. Repeated-root cyclic codes, which form a significant subclass of error-correcting codes, have…

Information Theory · Computer Science 2025-08-07 Wei Zhao , Weixian Li , Shenghao Yang , Fang-Wei Fu , Kenneth W. Shum

This paper tackles two problems that fall under the study of coding for insertions and deletions. These problems are motivated by several applications, among them is reconstructing strands in DNA-based storage systems. Under this paradigm,…

Information Theory · Computer Science 2025-06-23 Omer Sabary , Daniella Bar-Lev , Yotam Gershon , Alexander Yucovich , Eitan Yaakobi

A new set of DNA base-nucleic acid codes and their hypercomplex number representation have been introduced for taking the probability of each nucleotide into full account. A new scoring system has been proposed to suit the hypercomplex…

Other Quantitative Biology · Quantitative Biology 2014-03-12 Jian-Jun Shu , Li Shan Ouw

We consider a new family of codes, termed asymmetric Lee distance codes, that arise in the design and implementation of DNA-based storage systems and systems with parallel string transmission protocols. The codewords are defined over a…

Information Theory · Computer Science 2016-12-16 Ryan Gabrys , Han Mao Kiah , Olgica Milenkovic

In computational molecular biology, gene regulatory binding sites prediction in whole genome remains a challenge for the researchers. Now a days, the genome wide regulatory binding site prediction tools required either direct pattern…

Genomics · Quantitative Biology 2010-02-06 Chandra Prakash Singh , Feroz Khan , Sanjay Kumar Singh , Durg Singh Chauhan

The biggest challenge when using DNA as a storage medium is maintaining its stability. The relative occurrence of Guanine (G) and Cytosine (C) is essential for the longevity of DNA. In addition to that, reverse complementary base pairs…

Information Theory · Computer Science 2023-08-03 NallappaBhavithran G , Selvakumar R

We propose a unified theory of generalized weights for linear codes endowed with an arbitrary distance. Instead of relying on supports or anticodes, the weights of a code are defined via the intersections of the code with a chosen family of…

Information Theory · Computer Science 2025-12-22 Andrea Di Giusto , Elisa Gorla , Alberto Ravagnani

Storing digital data in synthetic DNA faces challenges in ensuring data reliability in the presence of edit errors--deletions, insertions, and substitutions--that occur randomly during various stages of the storage process. Current…

Information Theory · Computer Science 2025-09-11 Serge Kas Hanna

Synthetic DNA approaches 227.5 exabytes per gram of storage density with stability over millennial timescales. Realising this capacity requires error-correction codes that recover data from substantial synthesis and sequencing errors.…

Information Theory · Computer Science 2026-04-23 James L. Banal

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

Quantitative Methods · Quantitative Biology 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

We investigate the problem of maintaining an encoded distributed storage system when some nodes contain adversarial errors. Using the error-correction capabilities that are built into the existing redundancy of the system, we propose a…

Cryptography and Security · Computer Science 2015-03-17 Theodoros K. Dikaliotis , Alexandros G. Dimakis , Tracey Ho

In many modern data sets, High dimension low sample size (HDLSS) data is prevalent in many fields of studies. There has been an increased focus recently on using machine learning and statistical methods to mine valuable information out of…

Optimization and Control · Mathematics 2023-05-23 Srivathsan Amruth , Xin Yee Lam

Deep neural networks (DNN) have been widely applied in modern life, including critical domains like autonomous driving, making it essential to ensure the reliability and robustness of DNN-powered systems. As an analogy to code coverage…

Software Engineering · Computer Science 2022-01-04 Zhou Yang , Jieke Shi , Muhammad Hilmi Asyrofi , David Lo

The synthesis of DNA strands remains the most costly part of the DNA storage system. Thus, to make DNA storage system more practical, the time and materials used in the synthesis process have to be optimized. We consider the most common…

Information Theory · Computer Science 2023-05-15 Johan Chrisnata , Han Mao Kiah , Van Long Phuoc Pham

We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

One of the fundamental problems in machine learning is the estimation of a probability distribution from data. Many techniques have been proposed to study the structure of data, most often building around the assumption that observations…

Machine Learning · Statistics 2013-02-22 Oren Rippel , Ryan Prescott Adams

Large language models have demonstrated remarkable capabilities across many tasks, yet face significant challenges when dealing with recursive reasoning problems, those requiring the resolution of nested hierarchical structures. While prior…

Artificial Intelligence · Computer Science 2025-12-03 Zhiyuan He
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