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Is Segment Anything Model 3 (SAM3) capable in segmenting Any Pathology Images? Digital pathology segmentation spans tissue-level and nuclei-level scales, where traditional methods often suffer from high annotation costs and poor…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Qiuyu Kong , Shakiba Sharifi , Yiming Wang , Marco Cristani , Zanxi Ruan

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Zhongyi Shui , Yunlong Zhang , Kai Yao , Chenglu Zhu , Sunyi Zheng , Jingxiong Li , Honglin Li , Yuxuan Sun , Ruizhe Guo , Lin Yang

Segmentation is central to clinical diagnosis and monitoring, yet the reliability of modern foundation models in medical imaging still depends on the availability of precise prompts. The Segment Anything Model (SAM) offers powerful…

Semi-supervised learning (SSL) has achieved notable progress in medical image segmentation. To achieve effective SSL, a model needs to be able to efficiently learn from limited labeled data and effectively exploiting knowledge from abundant…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Juzheng Miao , Cheng Chen , Keli Zhang , Jie Chuai , Quanzheng Li , Pheng-Ann Heng

Foundational models such as the Segment Anything Model (SAM) are gaining traction in medical imaging segmentation, supporting multiple downstream tasks. However, such models are supervised in nature, still relying on large annotated…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Aishik Konwer , Zhijian Yang , Erhan Bas , Cao Xiao , Prateek Prasanna , Parminder Bhatia , Taha Kass-Hout

Promptable segmentation foundation models such as SAM3 have demonstrated strong generalization capabilities through interactive and concept-based prompting. However, their direct applicability to medical image segmentation remains limited…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Chongcong Jiang , Tianxingjian Ding , Chuhan Song , Jiachen Tu , Ziyang Yan , Yihua Shao , Zhenyi Wang , Yuzhang Shang , Tianyu Han , Yu Tian

Segment Anything Model (SAM) has gained significant recognition in the field of semantic segmentation due to its versatile capabilities and impressive performance. Despite its success, SAM faces two primary limitations: (1) it relies…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Yuchen Li , Li Zhang , Youwei Liang , Pengtao Xie

Open-set image segmentation poses a significant challenge because existing methods often demand extensive training or fine-tuning and generally struggle to segment unified objects consistently across diverse text reference expressions.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Zhihua Liu , Amrutha Saseendran , Lei Tong , Xilin He , Fariba Yousefi , Nikolay Burlutskiy , Dino Oglic , Tom Diethe , Philip Teare , Huiyu Zhou , Chen Jin

Promptable foundation models such as the Segment Anything Model (SAM) produce high-quality masks but remain semantically blind, relying on external prompts to specify categories. Existing vision-language approaches address this limitation…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Shayan Jalilian , Abdul Bais

Neural networks pre-trained on a self-supervision scheme have become the standard when operating in data rich environments with scarce annotations. As such, fine-tuning a model to a downstream task in a parameter-efficient but effective…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 Marc Fischer , Alexander Bartler , Bin Yang

Pixel-wise annotations are notoriously labourious and costly to obtain in the medical domain. To mitigate this burden, weakly supervised approaches based on bounding box annotations-much easier to acquire-offer a practical alternative.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Mélanie Gaillochet , Mehrdad Noori , Sahar Dastani , Christian Desrosiers , Hervé Lombaert

Segmentation is a fundamental task in computer vision, with prompt-driven methods gaining prominence due to their flexibility. The Segment Anything Model (SAM) excels at point-prompted segmentation, while text-based models, often leveraging…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Suzhe Xu , Jialin Peng , Chengyuan Zhang

Medical image segmentation plays a crucial role in clinical medicine, serving as a key tool for auxiliary diagnosis, treatment planning, and disease monitoring. However, traditional segmentation methods such as U-Net are often limited by…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Gaoyu Chen , Haixia Pan

Adapting large pre-trained foundation models, e.g., SAM, for medical image segmentation remains a significant challenge. A crucial step involves the formulation of a series of specialized prompts that incorporate specific clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Xiuqi Zheng , Yuhang Zhang , Haoran Zhang , Hongrui Liang , Xueqi Bao , Zhuqing Jiang , Qicheng Lao

The accurate segmentation of medical images is a crucial step in obtaining reliable morphological statistics. However, training a deep neural network for this task requires a large amount of labeled data to ensure high-accuracy results. To…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Xianjun Han , Qianqian Chen , Zhaoyang Xie , Xuejun Li , Hongyu Yang

Recent advances in promptable segmentation, such as the Segment Anything Model (SAM), have enabled flexible, high-quality mask generation across a wide range of visual domains. However, SAM and similar models remain fundamentally…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Tyler Ward , Abdullah Imran

In this paper, we propose a novel text promptable surgical instrument segmentation approach to overcome challenges associated with diversity and differentiation of surgical instruments in minimally invasive surgeries. We redefine the task…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Zijian Zhou , Oluwatosin Alabi , Meng Wei , Tom Vercauteren , Miaojing Shi

In this paper, we present PRISM, a Promptable and Robust Interactive Segmentation Model, aiming for precise segmentation of 3D medical images. PRISM accepts various visual inputs, including points, boxes, and scribbles as sparse prompts, as…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Hao Li , Han Liu , Dewei Hu , Jiacheng Wang , Ipek Oguz

Recently, foundation models trained on massive datasets to adapt to a wide range of tasks have attracted considerable attention and are actively being explored within the computer vision community. Among these, the Segment Anything Model…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Hyung-Il Kim , Kimin Yun , Jun-Seok Yun , Yuseok Bae

The recent advancements in large foundation models have driven the success of open-set image segmentation, a task focused on segmenting objects beyond predefined categories. Among various prompt types (such as points, boxes, texts, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Xiaoqi Wang , Clint Sebastian , Wenbin He , Liu Ren
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