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Diffusion models have achieved significant success in both natural image and medical image domains, encompassing a wide range of applications. Previous investigations in medical images have often been constrained to specific anatomical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Yongrui Yu , Yannian Gu , Shaoting Zhang , Xiaofan Zhang

The performance of single image super-resolution depends heavily on how to generate and complement high-frequency details to low-resolution images. Recently, diffusion-based DDPM models exhibit great potential in generating high-quality…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Xingjian Wang , Li Chai , Jiming Chen

Recent advancements in deep learning for medical image segmentation are often limited by the scarcity of high-quality training data.While diffusion models provide a potential solution by generating synthetic images, their effectiveness in…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Jianhao Xie , Ziang Zhang , Zhenyu Weng , Yuesheng Zhu , Guibo Luo

Fairness is an important topic for medical image analysis, driven by the challenge of unbalanced training data among diverse target groups and the societal demand for equitable medical quality. In response to this issue, our research adopts…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Wenyi Li , Haoran Xu , Guiyu Zhang , Huan-ang Gao , Mingju Gao , Mengyu Wang , Hao Zhao

Radiotherapy treatment planning often relies on time-consuming, trial-and-error adjustments that heavily depend on the expertise of specialists, while existing deep learning methods face limitations in generalization, prediction accuracy,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Hui Xie , Haiqin Hu , Lijuan Ding , Qing Li , Yue Sun , Tao Tan

Diffusion models have emerged as a promising approach for text generation, with recent works falling into two main categories: discrete and continuous diffusion models. Discrete diffusion models apply token corruption independently using…

Computation and Language · Computer Science 2025-05-29 Bocheng Li , Zhujin Gao , Linli Xu

Orthodontic treatment hinges on tooth alignment, which significantly affects occlusal function, facial aesthetics, and patients' quality of life. Current deep learning approaches predominantly concentrate on predicting transformation…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Yunbi Liu , Enqi Tang , Shiyu Li , Lei Ma , Juncheng Li , Shu Lou , Yongchu Pan , Qingshan Liu

Structure-based drug design (SBDD) is a critical task in drug discovery, requiring the generation of molecular information across two distinct modalities: discrete molecular graphs and continuous 3D coordinates. However, existing SBDD…

Computational Engineering, Finance, and Science · Computer Science 2025-03-28 Xiuyuan Hu , Guoqing Liu , Can Chen , Yang Zhao , Hao Zhang , Xue Liu

Standard Latent Diffusion Models rely on a complex, three-part architecture consisting of a separate encoder, decoder, and diffusion network, which are trained in multiple stages. This modular design is computationally inefficient, leads to…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Xiyuan Wang , Muhan Zhang

Synthesizing high-quality tabular data is an important topic in many data science tasks, ranging from dataset augmentation to privacy protection. However, developing expressive generative models for tabular data is challenging due to its…

Machine Learning · Computer Science 2025-02-18 Juntong Shi , Minkai Xu , Harper Hua , Hengrui Zhang , Stefano Ermon , Jure Leskovec

Diffusion models have achieved unprecedented performance in image generation, yet they suffer from slow inference due to their iterative sampling process. To address this, early-exiting has recently been proposed, where the depth of the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Daniel Gallo Fernández , Răzvan-Andrei Matişan , Alejandro Monroy Muñoz , Ana-Maria Vasilcoiu , Janusz Partyka , Tin Hadži Veljković , Metod Jazbec

This paper introduces StructDiff, a generative framework based on a single-scale diffusion model for single-image generation. Single-image generation aims to synthesize diverse samples with similar visual content to the source image by…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Yinxi He , Kang Liao , Chunyu Lin , Tianyi Wei , Yao Zhao

Structural topology optimization, which aims to find the optimal physical structure that maximizes mechanical performance, is vital in engineering design applications in aerospace, mechanical, and civil engineering. Generative adversarial…

Machine Learning · Computer Science 2022-12-07 François Mazé , Faez Ahmed

Motif scaffolding seeks to design scaffold structures for constructing proteins with functions derived from the desired motif, which is crucial for the design of vaccines and enzymes. Previous works approach the problem by inpainting or…

Biomolecules · Quantitative Biology 2024-06-06 Ke Liu , Weian Mao , Shuaike Shen , Xiaoran Jiao , Zheng Sun , Hao Chen , Chunhua Shen

The rapid advancement of diffusion models has enabled high-fidelity and semantically rich text-to-image generation; however, ensuring fairness and safety remains an open challenge. Existing methods typically improve fairness and safety at…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Silpa Vadakkeeveetil Sreelatha , Sauradip Nag , Muhammad Awais , Serge Belongie , Anjan Dutta

In this work, we propose a novel framework to enable diffusion models to adapt their generation quality based on real-time network bandwidth constraints. Traditional diffusion models produce high-fidelity images by performing a fixed number…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Xi Zhang , Hanwei Zhu , Yan Zhong , Jiamang Wang , Weisi Lin

Contact-rich assembly is fundamental in robotics but poses significant challenges due to uncertainties in relative poses, such as misalignments and small clearances in peg-in-hole tasks. Existing approaches typically address search and…

Effective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models…

Machine Learning · Computer Science 2025-03-04 Guanlue Li , Chenran Jiang , Ziqi Gao , Yu Liu , Chenyang Liu , Jiean Chen , Yong Huang , Jia Li

Designing a single molecule that modulates two targets is a promising strategy for polypharmacology, but it remains substantially harder than standard single-target generation because one candidate must satisfy two binding requirements…

Machine Learning · Computer Science 2026-05-26 Qingyuan Zeng , Pengxiang Cai , Zixin Guan , Ziyang Chen , Anglin Liu , Lang Qin , Xinyao Lai , Jintai Chen

Generative models often treat continuous data and discrete events as separate processes, creating a gap in modeling complex systems where they interact synchronously. To bridge this gap, we introduce JointDiff, a novel diffusion framework…

Machine Learning · Computer Science 2026-01-30 Guillem Capellera , Luis Ferraz , Antonio Rubio , Alexandre Alahi , Antonio Agudo