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Drug synergy prediction is a critical task in the development of effective combination therapies for complex diseases, including cancer. Although existing methods have shown promising results, they often operate as black-box predictors that…

Machine Learning · Computer Science 2025-11-05 Yi Luo , Haochen Zhao , Xiao Liang , Yiwei Liu , Yuye Zhang , Xinyu Li , Jianxin Wang

As we aim to control complex systems, use of a simulator in model-based reinforcement learning is becoming more common. However, it has been challenging to overcome the Reality Gap, which comes from nonlinear model bias and susceptibility…

Robotics · Computer Science 2017-05-16 Gilwoo Lee , Siddhartha S. Srinivasa , Matthew T. Mason

In this work, we consider causal inference in various high-dimensional treatment settings, including for single multi-valued treatments and vector treatments with binary or continuous components, when the number of treatments can be…

Statistics Theory · Mathematics 2026-02-26 Patrick Kramer , Edward H. Kennedy , Isaac M. Opper

Explainable recommendation systems leverage transparent reasoning to foster user trust and improve decision-making processes. Current approaches typically decouple recommendation generation from explanation creation, violating causal…

Artificial Intelligence · Computer Science 2025-03-12 Guanrong Li , Haolin Yang , Xinyu Liu , Zhen Wu , Xinyu Dai

We propose a formal model for counterfactual estimation with unobserved confounding in "data-rich" settings, i.e., where there are a large number of units and a large number of measurements per unit. Our model provides a bridge between the…

Econometrics · Economics 2025-04-03 Alberto Abadie , Anish Agarwal , Devavrat Shah

Causal inference is a science with multi-disciplinary evolution and applications. On the one hand, it measures effects of treatments in observational data based on experimental designs and rigorous statistical inference to draw causal…

Methodology · Statistics 2022-09-05 Jingying Zeng , Run Wang

The Causal Roadmap outlines a systematic approach to asking and answering questions of cause-and-effect: define the quantity of interest, evaluate needed assumptions, conduct statistical estimation, and carefully interpret results. To…

Methodology · Statistics 2024-05-30 Nerissa Nance , Maya L. Petersen , Mark van der Laan , Laura B. Balzer

Bayesian statistics has gained popularity in psychological research due to its intuitive uncertainty quantification and convenient information-updating rules. In many applications, however, prior distributions are introduced merely as…

Methodology · Statistics 2026-03-10 Yang Liu , Jonathan P. Williams , Jan Hannig

Causal graphs (CGs) are compact representations of the knowledge of the data generating processes behind the data distributions. When a CG is available, e.g., from the domain knowledge, we can infer the conditional independence (CI)…

Machine Learning · Computer Science 2021-08-18 Takeshi Teshima , Masashi Sugiyama

Causal fairness in databases is crucial to preventing biased and inaccurate outcomes in downstream tasks. While most prior work assumes a known causal model, recent efforts relax this assumption by enforcing additional constraints. However,…

Machine Learning · Computer Science 2026-03-27 Ying Zheng , Yangfan Jiang , Kian-Lee Tan

We consider continuous-time survival or more general event-history settings, where the aim is to infer the causal effect of a time-dependent treatment process. This is formalised as the effect on the outcome event of a (possibly…

Methodology · Statistics 2024-04-23 Kjetil Røysland , Pål Ryalen , Mari Nygård , Vanessa Didelez

Unmeasured confounding is a fundamental obstacle to causal inference from observational data. Latent-variable methods address this challenge by imputing unobserved confounders, yet many lack explicit model-based identification guarantees…

Computation · Statistics 2026-03-03 Yaxin Fang , Faming Liang

Causal inference is a vital aspect of multiple scientific disciplines and is routinely applied to high-impact applications such as medicine. However, evaluating the performance of causal inference methods in real-world environments is…

Machine Learning · Computer Science 2023-07-04 Mathieu Chevalley , Yusuf Roohani , Arash Mehrjou , Jure Leskovec , Patrick Schwab

Causal inference holds immense value in fields such as healthcare, economics, and social sciences. However, traditional causal analysis workflows impose significant technical barriers, requiring researchers to possess dual backgrounds in…

Artificial Intelligence · Computer Science 2026-02-13 Jiawei Zhu , Wei Chen , Ruichu Cai

In this paper we study the problems of estimating heterogeneity in causal effects in experimental or observational studies and conducting inference about the magnitude of the differences in treatment effects across subsets of the…

Machine Learning · Statistics 2022-06-08 Susan Athey , Guido Imbens

Typical causal effects are defined based on the marginal distribution of potential outcomes. However, many real-world applications require causal estimands involving the joint distribution of potential outcomes to enable more nuanced…

Methodology · Statistics 2026-04-17 Peng Wu , Xiaojie Mao

Current causal discovery approaches require restrictive model assumptions in the absence of interventional data to ensure structure identifiability. These assumptions often do not hold in real-world applications leading to a loss of…

Machine Learning · Statistics 2025-06-25 Anish Dhir , Ruby Sedgwick , Avinash Kori , Ben Glocker , Mark van der Wilk

Variational autoencoders (VAEs) and other generative methods have garnered growing interest not just for their generative properties but also for the ability to dis-entangle a low-dimensional latent variable space. However, few existing…

Machine Learning · Computer Science 2023-02-14 Sunay Bhat , Jeffrey Jiang , Omead Pooladzandi , Gregory Pottie

Debiased collaborative filtering aims to learn an unbiased prediction model by removing different biases in observational datasets. To solve this problem, one of the simple and effective methods is based on the propensity score, which…

Information Retrieval · Computer Science 2024-05-01 Haoxuan Li , Chunyuan Zheng , Yanghao Xiao , Peng Wu , Zhi Geng , Xu Chen , Peng Cui

A common goal in comparative effectiveness research is to estimate treatment effects on pre-specified subpopulations of patients. Though widely used in medical research, causal inference methods for such subgroup analysis remain…