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Transcriptional networks represent one of the most extensively studied types of systems in synthetic biology. Although the completeness of transcriptional networks for digital logic is well-established, *analog* computation plays a crucial…

Computational Complexity · Computer Science 2026-05-15 David Doty , Mina Latifi , David Soloveichick

We show that the Tangled Nature model can be interpreted as a general formulation of the quasi-species model by Eigen et al. in a frequency dependent fitness landscape. We present a detailed theoretical derivation of the mutation threshold,…

Statistical Mechanics · Physics 2009-11-07 Simone Avogadro di Collobiano , Kim Christensen , Henrik Jeldtoft Jensen

Quantitative characterization of bacterial growth has gathered substantial attention since Monod's pioneering study. Theoretical and experimental work has uncovered several laws for describing the log growth phase, in which the number of…

Biological Physics · Physics 2017-07-05 Yusuke Himeoka , Kunihiko Kaneko

We consider a birth and death process in which death is due to both `natural death' and to competition between individuals, modelled as a quadratic function of population size. The resulting `logistic branching process' has been proposed as…

Probability · Mathematics 2013-10-23 Alison Etheridge , Shidong Wang , Feng Yu

Rate-induced tipping (R-tipping) occurs when a ramp parameter changes rapidly enough to cause the system to tip between co-existing, attracting states, while noise-induced tipping (N-tipping) occurs when there are random transitions between…

Chaotic Dynamics · Physics 2024-10-02 Katherine Slyman , Emmanuel Fleurantin , Christopher K. R. T. Jones

Similar to humans and animals, deep artificial neural networks exhibit critical periods during which a temporary stimulus deficit can impair the development of a skill. The extent of the impairment depends on the onset and length of the…

Machine Learning · Computer Science 2019-02-26 Alessandro Achille , Matteo Rovere , Stefano Soatto

Coevolutionary arms races form between interacting populations that constitute each other's environment and respond to mutual changes. This inherently far-from-equilibrium process finds striking manifestations in the adaptive immune system,…

Biological Physics · Physics 2019-12-18 Hongda Jiang , Shenshen Wang

We study the phase transition from the persistence phase to the extinction phase for the SIRS (susceptible/ infected/ refractory/ susceptible) model of diseases spreading on small world network. We show the effects of all the parameters…

Physics and Society · Physics 2019-11-19 Mohammed Ali Saif

In order to model random density-dependence in population dynamics, we construct the random analogue of the well-known logistic process in the branching process' framework. This density-dependence corresponds to intraspecific competition…

Probability · Mathematics 2007-05-23 Amaury Lambert

We present an individual based model of evolutionary ecology. The reproduction rate of individuals characterized by their genome depends on the composition of the population in genotype space. Ecological features such as the taxonomy and…

Statistical Mechanics · Physics 2016-08-31 Matt Hall , Kim Christensen , Simone A. di Collobiano , Henrik Jeldtoft Jensen

Both genomic stability and sustenance of day-to-day life rely on efficient and accurate readout of the genetic code. Single-molecule experiments show that transcription and replication are highly stochastic and irregular processes, with the…

Biomolecules · Quantitative Biology 2012-01-26 Martin Depken , Juan M. R. Parrondo , Stephan W. Gril

We develop a definition of rate-induced tipping (R-tipping) in discrete-time dynamical systems (maps) and prove results giving conditions under which R-tipping will or will not happen. Specifically, we study (possibly non-invertible) maps…

Dynamical Systems · Mathematics 2019-07-29 Claire Kiers

A tipping point can be defined as an abrupt shift in the properties or behaviour of a system. Tipping points in complex systems from a wide variety of scientific disciplines have been compared to phase transitions in physics, but consistent…

Physics and Society · Physics 2023-02-28 Marieke M. Glazenburg , Luca Consoli , Alix McCollam

This study explores the connection between disinformation, defined as deliberate spread of false information, and rate-induced tipping (R-tipping), a phenomenon where systems undergo sudden changes due to rapid shifts in ex-ternal forces.…

Dynamical Systems · Mathematics 2024-01-23 Arindam Kumar Paul , M. Haider Ali Biswas

We discovered a dynamic phase transition induced by sexual reproduction. The dynamics is a pure Darwinian rule with both fundamental ingredients to drive evolution: 1) random mutations and crossings which act in the sense of increasing the…

Populations and Evolution · Quantitative Biology 2009-11-13 P. M. C. de Oliveira , S. Moss de Oliveira , D. Stauffer , S. Cebrat , A. Pekalski

When four species compete stochastically in a cyclic way, the formation of two teams of mutually neutral partners is observed. In this paper we study through numerical simulations the extinction processes that can take place in this system…

Populations and Evolution · Quantitative Biology 2013-11-14 Ben Intoy , Michel Pleimling

Biodiversity and extinction are central issues in evolution. Dynamical balance among different species in ecosystems is often described by deterministic replicator equations with moderate success. However, fluctuations are inevitable,…

Populations and Evolution · Quantitative Biology 2014-11-25 Tsung-Cheng Lu , Yi-Ko Chen , Hsiu-Hau Lin , Chun-Chung-Chen

The resilience, or stability, of major Earth system components is increasingly threatened by anthropogenic pressures, demanding reliable early warning signals for abrupt and irreversible regime shifts. Widely used data-driven resilience…

Adaptation and Self-Organizing Systems · Physics 2026-05-13 Teng Liu , Andreas Morr , Sebastian Bathiany , Lana L. Blaschke , Zhen Qian , Chan Diao , Taylor Smith , Niklas Boers

The phage $\lambda$ infection of an \textit{E. coli} cell has become a paradigm for understanding the molecular processes involved in gene expression and cell signaling. This system provides an example of a genetic switch, as cells with…

Biological Physics · Physics 2012-04-10 Nathan Borggren

The kinetics for the assembly of viral proteins into a population of capsids can be measured in vitro with size exclusion chromatography or dynamic light scattering, but extracting mechanistic information from these studies is challenging.…

Biomolecules · Quantitative Biology 2015-05-13 Michael F. Hagan
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