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Identifying cell types and subtypes in routine histopathology is fundamental for understanding disease. Existing tile-based models capture nuclear detail but miss the broader tissue context that influences cell identity. Current human…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Yinuo Xu , Yan Cui , Mingyao Li , Zhi Huang

In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Magdalini Paschali , Muhammad Ferjad Naeem , Walter Simson , Katja Steiger , Martin Mollenhauer , Nassir Navab

In real-world clinical settings, traditional deep learning-based classification methods struggle with diagnosing newly introduced disease types because they require samples from all disease classes for offline training. Class incremental…

Machine Learning · Computer Science 2024-06-11 Sana Ayromlou , Teresa Tsang , Purang Abolmaesumi , Xiaoxiao Li

In this work, we present a deep learning framework for multi-class breast cancer image classification as our submission to the International Conference on Image Analysis and Recognition (ICIAR) 2018 Grand Challenge on BreAst Cancer…

Computer Vision and Pattern Recognition · Computer Science 2018-02-06 Yeeleng S. Vang , Zhen Chen , Xiaohui Xie

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

Breast cancer has the highest mortality among cancers in women. Computer-aided pathology to analyze microscopic histopathology images for diagnosis with an increasing number of breast cancer patients can bring the cost and delays of…

Computer Vision and Pattern Recognition · Computer Science 2020-03-03 Abhijeet Patil , Dipesh Tamboli , Swati Meena , Deepak Anand , Amit Sethi

Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…

Computer Vision and Pattern Recognition · Computer Science 2022-07-13 Ming Feng , Kele Xu , Nanhui Wu , Weiquan Huang , Yan Bai , Changjian Wang , Huaimin Wang

Classifying fine-grained lesions is challenging due to minor and subtle differences in medical images. This is because learning features of fine-grained lesions with highly minor differences is very difficult in training deep neural…

Computer Vision and Pattern Recognition · Computer Science 2023-08-14 Wongi Park , Jongbin Ryu

Recent years witnessed remarkable progress in computational histopathology, largely fueled by deep learning. This brought the clinical adoption of deep learning-based tools within reach, promising significant benefits to healthcare,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-29 Ahmad Obeid , Said Boumaraf , Anabia Sohail , Taimur Hassan , Sajid Javed , Jorge Dias , Mohammed Bennamoun , Naoufel Werghi

The rapidly emerging field of deep learning-based computational pathology has demonstrated promise in developing objective prognostic models from histology whole slide images. However, most prognostic models are either based on histology or…

Computer Vision and Pattern Recognition · Computer Science 2021-08-06 Richard J. Chen , Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Jana Lipkova , Muhammad Shaban , Maha Shady , Mane Williams , Bumjin Joo , Zahra Noor , Faisal Mahmood

Convolutional neural networks excel in histopathological image classification, yet their pixel-level focus hampers explainability. Conversely, emerging graph convolutional networks spotlight cell-level features and medical implications.…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Ziqi Yang , Zhongyu Li , Chen Liu , Xiangde Luo , Xingguang Wang , Dou Xu , Chaoqun Li , Xiaoying Qin , Meng Yang , Long Jin

In this paper, we tackle the question of discovering an effective set of spatial filters to solve hyperspectral classification problems. Instead of fixing a priori the filters and their parameters using expert knowledge, we let the model…

Machine Learning · Statistics 2016-07-19 Devis Tuia , Rémi Flamary , Nicolas Courty

Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin \& eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher…

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Using deep learning models to diagnose cancer from histology data presents several challenges. Cancer grading and localization of regions of interest (ROIs) in these images normally relies on both image- and pixel-level labels, the latter…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Jérôme Rony , Soufiane Belharbi , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Pathological is crucial to cancer diagnosis. Usually, Pathologists draw their conclusion based on observed cell and tissue structure on histology slides. Rapid development in machine learning, especially deep learning have established…

Image and Video Processing · Electrical Eng. & Systems 2020-01-15 Jiangbo Shi , Zeyu Gao , Haichuan Zhang , Pargorn Puttapirat , Chunbao Wang , Xiangrong Zhang , Chen Li

Whole slide images (WSIs) pose unique challenges when training deep learning models. They are very large which makes it necessary to break each image down into smaller patches for analysis, image features have to be extracted at multiple…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Ozan Ciga , Tony Xu , Sharon Nofech-Mozes , Shawna Noy , Fang-I Lu , Anne L. Martel

Weak supervision learning on classification labels has demonstrated high performance in various tasks, while a few pixel-level fine annotations are also affordable. Naturally a question comes to us that whether the combination of…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Jiahui Li , Wen Chen , Xiaodi Huang , Zhiqiang Hu , Qi Duan , Hongsheng Li , Dimitris N. Metaxas , Shaoting Zhang

Deep neural networks (DNNs) have exhibited remarkable success in the field of histopathology image analysis. On the other hand, the contemporary trend of employing large models and extensive datasets has underscored the significance of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Cong Cong , Shiyu Xuan , Sidong Liu , Maurice Pagnucco , Shiliang Zhang , Yang Song

Hyperspectral imaging (HSI) shows great promise for surgical applications, offering detailed insights into biological tissue differences beyond what the naked eye can perceive. Refined labelling efforts are underway to train vision systems…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Junwen Wang , Oscar Maccormac , William Rochford , Aaron Kujawa , Jonathan Shapey , Tom Vercauteren