English
Related papers

Related papers: CoPeP: Benchmarking Continual Pretraining for Prot…

200 papers

Recent advances in natural language processing (NLP) can be largely attributed to the advent of pre-trained language models such as BERT and RoBERTa. While these models demonstrate remarkable performance on general datasets, they can…

Molecular Property Prediction (MPP) is a fundamental problem in drug discovery that has recently attracted growing attention. Large Language Models (LLMs), known for their impressive proficiency across domains, show promise as generalist…

Machine Learning · Computer Science 2026-05-28 Khiem Le , Sreejata Dey , Marcos Martínez Galindo , Vanessa Lopez , Ting Hua , Nitesh V. Chawla , Hoang Thanh Lam

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Oriel Perets , Michal Linial , Nadav Rappoport

While scaling laws have been continuously validated in large language models (LLMs) with increasing model parameters, the inherent tension between the inference demands of LLMs and the limited resources of edge devices poses a critical…

In this study, we expand upon the FLIP benchmark-designed for evaluating protein fitness prediction models in small, specialized prediction tasks-by assessing the performance of state-of-the-art large protein language models, including…

Machine Learning · Computer Science 2025-01-31 Manuel F. Mollon , Joaquin Gonzalez-Rodriguez , Alicia Lozano-Diez , Daniel Ramos , Doroteo T. Toledano

The emergence of Large Language Models (LLMs) has achieved tremendous success in the field of Natural Language Processing owing to diverse training paradigms that empower LLMs to effectively capture intricate linguistic patterns and…

Information Retrieval · Computer Science 2024-07-04 Lemei Zhang , Peng Liu , Yashar Deldjoo , Yong Zheng , Jon Atle Gulla

Pre-trained language models (PLMs) show impressive performance in various downstream NLP tasks. However, pre-training large language models demands substantial memory and training compute. Furthermore, due to the substantial resources…

Computation and Language · Computer Science 2024-04-01 HyunJin Kim , Young Jin Kim , JinYeong Bak

In spite of their superior performance, neural probabilistic language models (NPLMs) remain far less widely used than n-gram models due to their notoriously long training times, which are measured in weeks even for moderately-sized…

Computation and Language · Computer Science 2016-06-07 Andriy Mnih , Yee Whye Teh

Fueled by their remarkable ability to tackle diverse tasks across multiple domains, large language models (LLMs) have grown at an unprecedented rate, with some recent models containing trillions of parameters. This growth is accompanied by…

Machine Learning · Computer Science 2025-05-30 Athanasios Glentis , Jiaxiang Li , Qiulin Shang , Andi Han , Ioannis Tsaknakis , Quan Wei , Mingyi Hong

Neural models that do not rely on pre-training have excelled in the keyphrase generation task with large annotated datasets. Meanwhile, new approaches have incorporated pre-trained language models (PLMs) for their data efficiency. However,…

Computation and Language · Computer Science 2024-02-26 Di Wu , Wasi Uddin Ahmad , Kai-Wei Chang

The current era of natural language processing (NLP) has been defined by the prominence of pre-trained language models since the advent of BERT. A feature of BERT and models with similar architecture is the objective of masked language…

Computation and Language · Computer Science 2023-07-04 Ed S. Ma

Parameter-Efficient Fine-Tuning (PEFT) is widely used for adapting Large Language Models (LLMs) for various tasks. Recently, there has been an increasing demand for fine-tuning a single LLM for multiple tasks because it requires overall…

Computation and Language · Computer Science 2026-05-15 Anjir Ahmed Chowdhury , Syed Zawad , Xiaolong Ma , Xu Dong , Feng Yan

Protein structures are important for understanding their functions and interactions. Currently, many protein structure prediction methods are enriching the structure database. Discriminating the origin of structures is crucial for…

Biomolecules · Quantitative Biology 2024-10-24 Wenrui Gou , Wenhui Ge , Yang Tan , Mingchen Li , Guisheng Fan , Huiqun Yu

We develop a new continual meta-learning method to address challenges in sequential multi-task learning. In this setting, the agent's goal is to achieve high reward over any sequence of tasks quickly. Prior meta-reinforcement learning…

Machine Learning · Computer Science 2021-12-09 Glen Berseth , Zhiwei Zhang , Grace Zhang , Chelsea Finn , Sergey Levine

Large language models (LLMs) have demonstrated remarkable capabilities for medical question answering and programming, but their potential for generating interpretable computable phenotypes (CPs) is under-explored. In this work, we…

Machine Learning · Computer Science 2025-08-08 Guilherme Seidyo Imai Aldeia , Daniel S. Herman , William G. La Cava

Video Large Language Models (Video LLMs) have achieved significant success by adopting the paradigm of large-scale pre-training followed by supervised fine-tuning (SFT). However, existing approaches struggle with temporal reasoning due to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Shicheng Li , Lei Li , Kun Ouyang , Shuhuai Ren , Yuanxin Liu , Yuanxing Zhang , Fuzheng Zhang , Lingpeng Kong , Qi Liu , Xu Sun

Pretrained Language Models (PLMs) have excelled in various Natural Language Processing tasks, benefiting from large-scale pretraining and self-attention mechanism's ability to capture long-range dependencies. However, their performance on…

Computation and Language · Computer Science 2025-08-12 Chaoqun Cui , Siyuan Li , Kunkun Ma , Caiyan Jia

Pre-trained language models (PrLMs) have achieved great success on a wide range of natural language processing tasks by virtue of the universal language representation ability obtained by self-supervised learning on a large corpus. These…

Computation and Language · Computer Science 2022-10-21 Junlong Li , Zhuosheng Zhang , Hai Zhao

Large language models (LLMs) have shown remarkable performance on many different Natural Language Processing (NLP) tasks. Prompt engineering plays a key role in adding more to the already existing abilities of LLMs to achieve significant…

Computation and Language · Computer Science 2024-07-25 Shubham Vatsal , Harsh Dubey

Relevance modeling between queries and items stands as a pivotal component in commercial search engines, directly affecting the user experience. Given the remarkable achievements of large language models (LLMs) in various natural language…

Artificial Intelligence · Computer Science 2025-02-19 Kaixin Wu , Yixin Ji , Zeyuan Chen , Qiang Wang , Cunxiang Wang , Hong Liu , Baijun Ji , Jia Xu , Zhongyi Liu , Jinjie Gu , Yuan Zhou , Linjian Mo