Related papers: A model of tuberculosis progression using CompuCel…
Despite existing for millennia, tuberculosis (TB) remains a persistent global health challenge. A significant obstacle in controlling TB spread is the need for a rapid, portable, sensitive, and accurate diagnostic test. Currently, sputum…
Nowadays, Vector-Borne Diseases (VBDs) raise a severe threat for public health, accounting for a considerable amount of human illnesses. Recently, several surveillance plans have been put in place for limiting the spread of such diseases,…
The search to understand how the HIV virus spreads inside the human body and how the immune response works to control it has motivated studies related to Mathematical Immunology. Actually, researches include the idea of mathematical models…
Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine can be improved…
We present a spatial hybrid discrete-continuum modelling framework for the interaction dynamics between tumour cells and cytotoxic T cells, which play a pivotal role in the immune response against tumours. In this framework, tumour cells…
Cellular aggregates play a significant role in the evolution of biological systems such as tumor growth, tissue spreading, wound healing, and biofilm formation. Analysis of such biological systems, in principle, includes examining the…
Type 1 diabetes (T1D) is an autoimmune disease of the beta cells of the pancreas. The nonobese diabetic (NOD) mouse is a commonly used animal model, with roughly an 80% incidence rate of T1D among females. In 100% of NOD mice, macrophages…
Bacteraemia, a bloodstream infection with high morbidity and mortality rates, poses significant diagnostic challenges. Accurate diagnosis through blood cultures is resource-intensive. Developing a machine learning model to predict blood…
Magombedze and Mulder in 2013 studied the gene regulatory system of Mycobacterium Tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the…
Toxoplasma gondii is the causative agent responsible for toxoplasmosis and serves as one of the most common parasites in the world. For a successful lytic cycle, T. gondii must traverse biological barriers in order to invade host cells, and…
Airborne pandemics have caused millions of deaths worldwide, large-scale economic losses, and catastrophic sociological shifts in human history. Researchers have developed multiple mathematical models and computational frameworks to…
EC funded STriTuVaD project aims to test, through a phase IIb clinical trial, two of the most advanced therapeutic vaccines against tuberculosis. In parallel, we have extended the Universal Immune System Simulator to include all relevant…
Tuberculosis remains a critical global health issue, particularly in resource-limited and remote areas. Early detection is vital for treatment, yet the lack of skilled radiologists underscores the need for artificial intelligence…
In face of climate change and increasing urbanization, the predictive mosquito-borne diseases (MBD) transmission models require constant updates. Thus, is urgent to comprehend the driving forces of this non stationary behavior, observed…
Physical contact or proximity is often a necessary condition for the spread of infectious diseases. Common destinations, typically referred to as hubs or points of interest, are arguably the most effective spots for the type of disease…
Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large. The cytoskeleton,…
Microbes are everywhere, including in and on our bodies, and have been shown to play key roles in a variety of prevalent human diseases. Consequently, there has been intense interest in the design of bacteriotherapies or "bugs as drugs,"…
The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organisation of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell…
Chlamydiae are bacteria with an interesting unusual developmental cycle. A single bacterium in its infectious form (elementary body, EB) enters the host cell, where it converts into its dividing form (reticulate body, RB), and divides by…
Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. Focusing on the early stages of tumor evolution, we enunciate the principles involved in cell dynamics and highlight…