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There exist numerous diagnostic tasks in pathology. Conventional computational pathology formulates and tackles them as independent and individual image classification problems, thereby resulting in computational inefficiency and high…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Boram Song , Seoung Wan Chae , Jin Tae Kwak

Most existing text recognition methods are trained on large-scale synthetic datasets due to the scarcity of labeled real-world datasets. Synthetic images, however, cannot faithfully reproduce real-world scenarios, such as uneven…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Zhengmi Tang , Yuto Mitsui , Tomo Miyazaki , Shinichiro Omachi

Few-shot learning is an established topic in natural images for years, but few work is attended to histology images, which is of high clinical value since well-labeled datasets and rare abnormal samples are expensive to collect. Here, we…

Image and Video Processing · Electrical Eng. & Systems 2022-02-21 Jiawei Yang , Hanbo Chen , Jiangpeng Yan , Xiaoyu Chen , Jianhua Yao

The remarkable performance of large multimodal models (LMMs) has attracted significant interest from the image segmentation community. To align with the next-token-prediction paradigm, current LMM-driven segmentation methods either use…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Tao Wang , Changxu Cheng , Lingfeng Wang , Senda Chen , Wuyue Zhao

Multiplex imaging is revolutionizing pathology by enabling the simultaneous visualization of multiple biomarkers within tissue samples, providing molecular-level insights that traditional hematoxylin and eosin (H&E) staining cannot provide.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-06 Hyun-Jic Oh , Junsik Kim , Zhiyi Shi , Yichen Wu , Yu-An Chen , Peter K Sorger , Hanspeter Pfister , Won-Ki Jeong

Medical Vision-language models (VLMs) have shown remarkable performances in various medical imaging domains such as histo\-pathology by leveraging pre-trained, contrastive models that exploit visual and textual information. However,…

Robust generalization beyond training distributions remains a critical challenge for deep neural networks. This is especially pronounced in medical image analysis, where data is often scarce and covariate shifts arise from different…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Francesco Di Salvo , Sebastian Doerrich , Jonas Alle , Christian Ledig

While federated learning is a promising approach for training deep learning models over distributed sensitive datasets, it presents new challenges for machine learning, especially when applied in the medical domain where multi-centric data…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Mathieu Andreux , Jean Ogier du Terrail , Constance Beguier , Eric W. Tramel

The different stain styles of cytopathological images have a negative effect on the generalization ability of automated image analysis algorithms. This article proposes a new framework that normalizes the stain style for cytopathological…

Image and Video Processing · Electrical Eng. & Systems 2019-09-12 Xihao Chen , Jingya Yu , Li Chen , Shaoqun Zeng , Xiuli Liu , Shenghua Cheng

Deep learning has led to remarkable advancements in computational histopathology, e.g., in diagnostics, biomarker prediction, and outcome prognosis. Yet, the lack of annotated data and the impact of batch effects, e.g., systematic technical…

Machine Learning · Computer Science 2024-11-11 Jonah Kömen , Hannah Marienwald , Jonas Dippel , Julius Hense

Histopathology image analysis plays a critical role in cancer diagnosis and treatment. To automatically segment the cancerous regions, fully supervised segmentation algorithms require labor-intensive and time-consuming labeling at the pixel…

Image and Video Processing · Electrical Eng. & Systems 2019-08-29 Gang Xu , Zhigang Song , Zhuo Sun , Calvin Ku , Zhe Yang , Cancheng Liu , Shuhao Wang , Jianpeng Ma , Wei Xu

Medical image segmentation is a critical step in computer-aided diagnosis, and convolutional neural networks are popular segmentation networks nowadays. However, the inherent local operation characteristics make it difficult to focus on the…

Computer Vision and Pattern Recognition · Computer Science 2023-05-18 Fenghe Tang , Jianrui Ding , Lingtao Wang , Min Xian , Chunping Ning

Foundation models have revolutionized computational pathology by achieving remarkable success in high-level diagnostic tasks, yet the critical challenge of low-level image enhancement remains largely unaddressed. Real-world pathology images…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Ziyi Liu , Zhe Xu , Jiabo Ma , Wenqaing Li , Junlin Hou , Fuxiang Huang , Xi Wang , Ronald Cheong Kin Chan , Terence Tsz Wai Wong , Hao Chen

We present the Universal Latent Homeomorphic Manifold (ULHM), a framework that unifies semantic representations (e.g., human descriptions, diagnostic labels) and observation-driven machine representations (e.g., pixel intensities, sensor…

Image and Video Processing · Electrical Eng. & Systems 2026-02-05 Tong Wu , Tayab Uddin Wara , Daniel Hernandez , Sidong Lei

Histopathological imaging is vital for cancer research and clinical practice, with multiplexed Immunofluorescence (MxIF) and Hematoxylin and Eosin (H&E) providing complementary insights. However, aligning different stains at the cell level…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jun Jiang , Raymond Moore , Brenna Novotny , Leo Liu , Zachary Fogarty , Ray Guo , Markovic Svetomir , Chen Wang

We focus on the problem of training convolutional neural networks on gigapixel histopathology images to predict image-level targets. For this purpose, we extend Neural Image Compression (NIC), an image compression framework that reduces the…

Image and Video Processing · Electrical Eng. & Systems 2020-04-16 David Tellez , Diederik Hoppener , Cornelis Verhoef , Dirk Grunhagen , Pieter Nierop , Michal Drozdzal , Jeroen van der Laak , Francesco Ciompi

Contrastive Learning (CL) is a recent representation learning approach, which encourages inter-class separability and intra-class compactness in learned image representations. Since medical images often contain multiple semantic classes in…

Computer Vision and Pattern Recognition · Computer Science 2021-08-09 Prashant Pandey , Ajey Pai , Nisarg Bhatt , Prasenjit Das , Govind Makharia , Prathosh AP , Mausam

Images suffer from heavy spatial redundancy because pixels in neighboring regions are spatially correlated. Existing approaches strive to overcome this limitation by reducing less meaningful image regions. However, current leading methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Yang Luo , Zhineng Chen , Peng Zhou , Zuxuan Wu , Xieping Gao , Yu-Gang Jiang

The latent representation in learned image compression encompasses channel-wise, local spatial, and global spatial correlations, which are essential for the entropy model to capture for conditional entropy minimization. Efficiently…

Image and Video Processing · Electrical Eng. & Systems 2025-10-29 Wei Jiang , Jiayu Yang , Yongqi Zhai , Feng Gao , Ronggang Wang

Automating medical report generation from histopathology images is a critical challenge requiring effective visual representations and domain-specific knowledge. Inspired by the common practices of human experts, we propose an in-context…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Shih-Wen Liu , Hsuan-Yu Fan , Wei-Ta Chu , Fu-En Yang , Yu-Chiang Frank Wang