Related papers: A Proper Scoring Rule for Virtual Staining
Implicit models, which allow for the generation of samples but not for point-wise evaluation of probabilities, are omnipresent in real-world problems tackled by machine learning and a hot topic of current research. Some examples include…
This paper considers the problem of utilizing a large-scale text-to-image diffusion model to tackle the challenging Inexact Segmentation (IS) task. Unlike traditional approaches that rely heavily on discriminative-model-based paradigms or…
Deep generative models (DGMs) of images are now sufficiently mature that they produce nearly photorealistic samples and obtain scores similar to the data distribution on heuristics such as Frechet Inception Distance (FID). These results,…
Immunohistochemistry (IHC) is essential for assessing specific immune biomarkers like Human Epidermal growth-factor Receptor 2 (HER2) in breast cancer. However, the traditional protocols of obtaining IHC stains are resource-intensive,…
There has been a growing excitement that implicit graph generative models could be used to design or discover new molecules for medicine or material design. Because these molecules have not been discovered, they naturally lie in unexplored…
Three-dimensional X-ray histology techniques offer a non-invasive alternative to conventional 2D histology, enabling volumetric imaging of biological tissues without the need for physical sectioning or chemical staining. However, the…
We propose a virtual staining methodology based on Generative Adversarial Networks to map histopathology images of breast cancer tissue from H&E stain to PHH3 and vice versa. We use the resulting synthetic images to build Convolutional…
Autoregressive video diffusion models are capable of long rollouts that are stable and consistent with history, but they are unable to guide the current generation with conditioning from the future. In camera-guided video generation with a…
The Generative Adversarial Network (GAN) is a state-of-the-art technique in the field of deep learning. A number of recent papers address the theory and applications of GANs in various fields of image processing. Fewer studies, however,…
Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic…
Generative AI models have recently achieved astonishing results in quality and are consequently employed in a fast-growing number of applications. However, since they are highly data-driven, relying on billion-sized datasets randomly…
Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression,…
Adversarial Imitation Learning is traditionally framed as a two-player zero-sum game between a learner and an adversarially chosen cost function, and can therefore be thought of as the sequential generalization of a Generative Adversarial…
Microscopy enables direct observation of cellular morphology in 3D, with transmitted-light methods offering low-cost, minimally invasive imaging and fluorescence microscopy providing specificity and contrast. Virtual staining combines these…
Chemical staining methods are dependable but require extensive time, expensive chemicals, and raise environmental concerns. These challenges highlight the need for alternative solutions like virtual staining, which accelerates the…
While learned image compression (LIC) focuses on efficient data transmission, generative image compression (GIC) extends this framework by integrating generative modeling to produce photo-realistic reconstructed images. In this paper, we…
Immunohistochemical (IHC) staining enables precise molecular profiling of protein expression, with over 200 clinically available antibody-based tests in modern pathology. However, comprehensive IHC analysis is frequently limited by…
Style transfer is a field with growing interest and use cases in deep learning. Recent work has shown Generative Adversarial Networks(GANs) can be used to create realistic images of virtually stained slide images in digital pathology with…
Statistical models are central to machine learning with broad applicability across a range of downstream tasks. The models are controlled by free parameters that are typically estimated from data by maximum-likelihood estimation or…
We introduce path-sampled integrated gradients (PS-IG), a framework that generalizes feature attribution by computing the expected value over baselines sampled along the linear interpolation path. We prove that PS-IG is mathematically…