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Clinical trials are critical for drug development but often suffer from expensive and inefficient patient recruitment. In recent years, machine learning models have been proposed for speeding up patient recruitment via automatically…

Machine Learning · Computer Science 2023-07-20 Brandon Theodorou , Cao Xiao , Jimeng Sun

Understanding black-box machine learning models is crucial for their widespread adoption. Learning globally interpretable models is one approach, but achieving high performance with them is challenging. An alternative approach is to explain…

Machine Learning · Computer Science 2022-09-23 Jinsung Yoon , Sercan O. Arik , Tomas Pfister

Classifying images with an interpretable decision-making process is a long-standing problem in computer vision. In recent years, Prototypical Part Networks has gained traction as an approach for self-explainable neural networks, due to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Zhijie Zhu , Lei Fan , Maurice Pagnucco , Yang Song

Most Probable Explanation (MPE) inference in Probabilistic Graphical Models (PGMs) is a fundamental yet computationally challenging problem arising in domains such as diagnosis, planning, and structured prediction. In many practical…

Artificial Intelligence · Computer Science 2026-02-03 Brij Malhotra , Shivvrat Arya , Tahrima Rahman , Vibhav Giridhar Gogate

In artificial intelligence (AI), the complexity of many models and processes surpasses human understanding, making it challenging to determine why a specific prediction is made. This lack of transparency is particularly problematic in…

Machine Learning · Statistics 2025-06-30 Alexandra Stadler , Werner G. Müller , Radoslav Harman

Background and Objective: Prototype-based methods improve interpretability by learning fine-grained part-prototypes; however, their visualization in the input pixel space is not always consistent with human-understandable biomarkers. In…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Marzieh Oghbaie , Teresa Araújo , Hrvoje Bogunović

Objective skill assessment in high-stakes procedural environments requires models that not only decode underlying cognitive and motor processes but also generalize across tasks, individuals, and experimental contexts. While prior work has…

Signal Processing · Electrical Eng. & Systems 2025-07-01 A. Subedi , S. De , L. Cavuoto , S. Schwaitzberg , M. Hackett , J. Norfleet

Pretrained transformer-based Language Models (LMs) are well-known for their ability to achieve significant improvement on NLP tasks, but their black-box nature, which leads to a lack of interpretability, has been a major concern. My…

Computation and Language · Computer Science 2024-12-06 Ximing Wen

Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.…

Machine Learning · Computer Science 2020-07-02 Abhishek Ghose , Balaraman Ravindran

Interpretable deep learning models have received widespread attention in the field of image recognition. Due to the unique multi-instance learning of medical images and the difficulty in identifying decision-making regions, many…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Yitao Peng , Lianghua He , Die Hu , Yihang Liu , Longzhen Yang , Shaohua Shang

We propose Partially Interpretable Estimators (PIE) which attribute a prediction to individual features via an interpretable model, while a (possibly) small part of the PIE prediction is attributed to the interaction of features via a…

Machine Learning · Computer Science 2021-05-07 Tong Wang , Jingyi Yang , Yunyi Li , Boxiang Wang

In meta-learning approaches, it is difficult for a practitioner to make sense of what kind of representations the model employs. Without this ability, it can be difficult to both understand what the model knows as well as to make meaningful…

Machine Learning · Computer Science 2022-04-05 Pedro Sandoval-Segura , Wallace Lawson

We present a deformable prototypical part network (Deformable ProtoPNet), an interpretable image classifier that integrates the power of deep learning and the interpretability of case-based reasoning. This model classifies input images by…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Jon Donnelly , Alina Jade Barnett , Chaofan Chen

In settings where both spurious and causal predictors are available, standard neural networks trained under the objective of empirical risk minimization (ERM) with no additional inductive biases tend to have a dependence on a spurious…

Machine Learning · Computer Science 2025-03-07 Louis McConnell

The rapid advancement of deep neural networks has significantly improved various tasks, such as image and speech recognition. However, as the complexity of these models increases, so does the computational cost and the number of parameters,…

Machine Learning · Computer Science 2023-07-18 Davide Giacomini , Maeesha Binte Hashem , Jeremiah Suarez , Swarup Bhunia , Amit Ranjan Trivedi

Deep neural networks exhibit remarkable performance, yet their black-box nature limits their utility in fields like healthcare where interpretability is crucial. Existing explainability approaches often sacrifice accuracy and lack…

Machine Learning · Computer Science 2025-04-08 Linhui Huang , Sayeri Lala , Niraj K. Jha

Interpretable insights from predictive models remain critical in bio-statistics, particularly when assessing causality, where classical statistical and machine learning methods often provide inherent clarity. While Neural Networks (NNs)…

Applications · Statistics 2025-05-02 Jean-Baptiste A. Conan

The MRI-derived brain network serves as a pivotal instrument in elucidating both the structural and functional aspects of the brain, encompassing the ramifications of diseases and developmental processes. However, prevailing methodologies,…

Machine Learning · Computer Science 2024-05-24 Haoteng Tang , Guodong Liu , Siyuan Dai , Kai Ye , Kun Zhao , Wenlu Wang , Carl Yang , Lifang He , Alex Leow , Paul Thompson , Heng Huang , Liang Zhan

Mining human-brain networks to discover patterns that can be used to discriminate between healthy individuals and patients affected by some neurological disorder, is a fundamental task in neuroscience. Learning simple and interpretable…

Social and Information Networks · Computer Science 2020-06-11 Tommaso Lanciano , Francesco Bonchi , Aristides Gionis

Machine learning models offer powerful predictive capabilities but often lack transparency. Local Interpretable Model-agnostic Explanations (LIME) addresses this by perturbing features and measuring their impact on a model's output. In…

Machine Learning · Computer Science 2024-12-24 Nelson Colón Vargas