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As an injury heals, an embryo develops, or a carcinoma spreads, epithelial cells systematically change their shape. In each of these processes cell shape is studied extensively, whereas variation of shape from cell-to-cell is dismissed most…

Fluid deformable surfaces are ubiquitous in cell and tissue biology, including lipid bilayers, the actomyosin cortex, or epithelial cell sheets. These interfaces exhibit a complex interplay between elasticity, low Reynolds number…

Fluid Dynamics · Physics 2019-06-12 Alejandro Torres-Sánchez , Daniel Millán , Marino Arroyo

Diffusion-driven patterns appear on curved surfaces in many settings, initiated by unstable modes of an underlying Laplacian operator. On a flat surface or perfect sphere, the patterns are degenerate, reflecting translational/rotational…

Soft Condensed Matter · Physics 2025-09-09 John R. Frank , Jemal Guven , Mehran Kardar , Leyna Shackleton

There are three fundamental physical processes that gives rise to the morphology of a surface: deposition, surface diffusion and desorption. The characteristics of the interfaces generated by the combination of deposition and surface…

Statistical Mechanics · Physics 2007-05-23 Juan R. Sanchez

Programming the non-uniform growth of a responsive polymer gel has emerged as a powerful tool to shape sheets into prescribed three dimensional shapes. We demonstrate that shapes with zero Gaussian curvature, except at singularities,…

Soft Condensed Matter · Physics 2014-10-29 N. P. Bende , R. C. Hayward , C. D. Santangelo

The structural properties of packed soft-core particles provide a platform to understand the cross-pollinated physical concepts in solid-state- and soft-matter physics. Confined on spherical surface, the traditional differential geometry…

Soft Condensed Matter · Physics 2025-01-06 Han Xie , Wenyu Liu , Zhenyue Lu , Jeff Z. Y. Chen , Yao Li

Experiments on supported lipid bilayers featuring liquid ordered/disordered domains have shown that the spatial arrangement of the lipid domains and their chemical composition are strongly affected by the curvature of the substrate.…

Soft Condensed Matter · Physics 2021-02-17 Melissa Rinaldin , Piermarco Fonda , Luca Giomi , Daniela J. Kraft

In this article, we propose a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues. Such epithelia undergo large-scale deformation during…

Tissues and Organs · Quantitative Biology 2017-09-08 Matthias Merkel , Raphaël Etournay , Marko Popović , Guillaume Salbreux , Suzanne Eaton , Frank Jülicher

In the growth of bacterial colonies, a great variety of complex patterns are observed in experiments, depending on external conditions and the bacterial species. Typically, existing models employ systems of reaction-diffusion equations or…

Biological Physics · Physics 2019-11-12 Lautaro Vassallo , David Hansmann , Lidia A. Braunstein

Morphological trends in growing colonies of living cells are at the core of physiological and evolutionary processes. Using active gel equations, which include cell division, we show that shape changes during the growth can be regulated by…

Soft Condensed Matter · Physics 2016-07-27 Amin Doostmohammadi , Sumesh P. Thampi , Julia M. Yeomans

Biological cells are able to generate intricate structures and respond to external stimuli, sculpting their membrane from within. Simplified biomimetic systems can aid in understanding the principles which govern these shape changes and…

A systematic investigation of the phase separation dynamics in self-assembled multi-component bilayer fluid vesicles and open membranes is presented. We use large-scale dissipative particle dynamics to explicitly account for solvent,…

Soft Condensed Matter · Physics 2015-06-25 Mohamed Laradji , P. B. Sunil Kumar

Coordinated cellular movements are key processes in tissue morphogenesis. Using a cell-based modeling approach we study the dynamics of epithelial layers lining surfaces with constant and varying curvature. We demonstrate that extrinsic…

Soft Condensed Matter · Physics 2024-03-21 Lea Happel , Axel Voigt

Static friction induced by moir\'e superstructure in twisted incommensurate finite layered material interfaces reveals unique double periodicity and lack of scaling with contact size. The underlying mechanism involves compensation of…

Applied Physics · Physics 2023-08-08 Weidong Yan , Xiang Gao , Wengen Ouyang , Ze Liu , Oded Hod , Michael Urbakh

The surface curvature of membranes, interfaces, and substrates plays a crucial role in shaping the self-assembly of particles adsorbed on these surfaces. However, little is known about the interplay between particle anisotropy and surface…

Soft Condensed Matter · Physics 2025-10-30 Gautam Bordia , Thomas P. Russell , Ahmad K. Omar

A coarse-grained molecular model, which consists of a spherical particle and an orientation vector, is proposed to simulate lipid membrane on a large length scale. The solvent is implicitly represented by an effective attractive interaction…

Soft Condensed Matter · Physics 2015-05-20 Hiroshi Noguchi

Under hard-agar and nutrient-rich conditions, a cell of $Bacillus$ $subtilis$ grows as a single filament owing to the failure of cell separation after each growth and division cycle. The self-elongating filament of cells shows sequential…

Soft Condensed Matter · Physics 2015-10-16 Ryojiro Honda , Jun-ichi Wakita , Makoto Katori

After a brief introduction to several variational problems in the study of shapes of thin thickness structures, we deal with variational problems on 2-dimensional surface in 3-dimensional Euclidian space by using exterior differential…

Mathematical Physics · Physics 2007-05-23 Z. C. Tu , Z. C. Ou-Yang

Shape transformations of flat bilayer membranes and vesicles induced by hydrolysis and condensation reactions of amphiphilic molecules are studied using coarse-grained molecular dynamics simulations. The hydrolysis and condensation…

Soft Condensed Matter · Physics 2018-01-31 Koh M. Nakagawa , Hiroshi Noguchi

Biological systems can form complex three-dimensional structures through the collective behavior of agents that share a common update rule and operate without central control. How such distributed control gives rise to precise global…

Machine Learning · Computer Science 2026-05-11 Seong Ho Pahng , Guoye Guan , Benjamin Fefferman , Sahand Hormoz