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Performance prediction is a method to estimate the performance of Language Models (LMs) on various Natural Language Processing (NLP) tasks, mitigating computational costs associated with model capacity and data for fine-tuning. Our paper…

Computation and Language · Computer Science 2024-12-17 David Anugraha , Genta Indra Winata , Chenyue Li , Patrick Amadeus Irawan , En-Shiun Annie Lee

The prediction of protein-protein interactions (PPIs) is crucial for understanding biological functions and diseases. Previous machine learning approaches to PPI prediction mainly focus on direct physical interactions, ignoring the broader…

Biomolecules · Quantitative Biology 2024-07-15 Mingyu Jin , Haochen Xue , Zhenting Wang , Boming Kang , Ruosong Ye , Kaixiong Zhou , Mengnan Du , Yongfeng Zhang

Protein language models (pLMs) have recently gained significant attention for their ability to uncover relationships between sequence, structure, and function from evolutionary statistics, thereby accelerating therapeutic drug discovery.…

Machine Learning · Computer Science 2026-03-04 Darshan Patil , Pranshu Malviya , Mathieu Reymond , Quentin Fournier , Sarath Chandar

Despite rapid progress in large language models (LLMs), their performance on a vast majority of languages remains unsatisfactory. In this paper, we study building language-specific LLMs by adapting monolingual and multilingual LLMs. We…

Computation and Language · Computer Science 2024-10-31 Atula Tejaswi , Nilesh Gupta , Eunsol Choi

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers…

Pretrained language models (PLMs) are today the primary model for natural language processing. Despite their impressive downstream performance, it can be difficult to apply PLMs to new languages, a barrier to making their capabilities…

Computation and Language · Computer Science 2024-01-15 Yihong Chen , Kelly Marchisio , Roberta Raileanu , David Ifeoluwa Adelani , Pontus Stenetorp , Sebastian Riedel , Mikel Artetxe

Natural language processing (NLP) has significantly influenced scientific domains beyond human language, including protein engineering, where pre-trained protein language models (PLMs) have demonstrated remarkable success. However,…

Computation and Language · Computer Science 2025-03-20 Yang Tan , Chen Liu , Jingyuan Gao , Banghao Wu , Mingchen Li , Ruilin Wang , Lingrong Zhang , Huiqun Yu , Guisheng Fan , Liang Hong , Bingxin Zhou

Large Language Models (LLM) have dominated the science and media landscape duo to their impressive performance on processing large chunks of data and produce human-like levels of text. Nevertheless, their huge energy demand and slow…

Computation and Language · Computer Science 2026-01-12 Felix Köster , Atsushi Uchida

The exponential increase in scientific literature and online information necessitates efficient methods for extracting knowledge from textual data. Natural language processing (NLP) plays a crucial role in addressing this challenge,…

Computation and Language · Computer Science 2025-10-22 Zhyar Rzgar K. Rostam , Gábor Kertész

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

The field of natural language processing (NLP) has recently seen a large change towards using pre-trained language models for solving almost any task. Despite showing great improvements in benchmark datasets for various tasks, these models…

Computation and Language · Computer Science 2022-05-24 Lukas Lange , Heike Adel , Jannik Strötgen , Dietrich Klakow

Large language models (LLMs) are a class of artificial intelligence models based on deep learning, which have great performance in various tasks, especially in natural language processing (NLP). Large language models typically consist of…

Quantitative Methods · Quantitative Biology 2025-02-04 Jiajia Liu , Mengyuan Yang , Yankai Yu , Haixia Xu , Tiangang Wang , Kang Li , Xiaobo Zhou

Speech Language Models (SLMs) aim to learn language from raw audio, without textual resources. Despite significant advances, our current models exhibit weak syntax and semantic abilities. However, if the scaling properties of neural…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-13 Santiago Cuervo , Ricard Marxer

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Data in biology is redundant, noisy, and sparse. How does the type and scale of available data impact model performance? In this work, we specifically investigate how protein language models (pLMs) scale with increasing pretraining data. We…

Quantitative Methods · Quantitative Biology 2025-07-31 Aviv Spinner , Erika DeBenedictis , Corey M. Hudson

Do machines and humans process language in similar ways? Recent research has hinted at the affirmative, showing that human neural activity can be effectively predicted using the internal representations of language models (LMs). Although…

Computation and Language · Computer Science 2025-01-15 Yuchen Zhou , Emmy Liu , Graham Neubig , Michael J. Tarr , Leila Wehbe

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

The meanings of words and phrases depend not only on where they are used (contexts) but also on who use them (writers). Pretrained language models (PLMs) are powerful tools for capturing context, but they are typically pretrained and…

Computation and Language · Computer Science 2023-09-15 Daisuke Oba , Naoki Yoshinaga , Masashi Toyoda

The rapid advancement of artificial intelligence, particularly with the development of Large Language Models (LLMs) built on the transformer architecture, has redefined the capabilities of natural language processing. These models now…

Computation and Language · Computer Science 2025-02-11 Andrea Matarazzo , Riccardo Torlone

Current Large Language Models (LLMs) for understanding proteins primarily treats amino acid sequences as a text modality. Meanwhile, Protein Language Models (PLMs), such as ESM-2, have learned massive sequential evolutionary knowledge from…

Machine Learning · Computer Science 2024-12-17 Nuowei Liu , Changzhi Sun , Tao Ji , Junfeng Tian , Jianxin Tang , Yuanbin Wu , Man Lan
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