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Related papers: The Sim-to-Real Gap in MRS Quantification: A Syste…

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Quantification of metabolites from magnetic resonance spectra (MRS) has many applications in medicine and psychology, but remains a challenging task despite considerable research efforts. For example, the neurotransmitter…

Image and Video Processing · Electrical Eng. & Systems 2019-09-10 M. Chandler , C. Jenkins , S. M. Shermer , F. C. Langbein

Magnetic resonance spectroscopy (MRS) is an important technique in biomedical research and it has the unique capability to give a non-invasive access to the biochemical content (metabolites) of scanned organs. In the literature, the…

Computer Vision and Pattern Recognition · Computer Science 2018-06-20 Nima Hatami , Michaël Sdika , Hélène Ratiney

Many tools exist for the quantification of GABA-edited magnetic resonance spectroscopy (MRS) data. Despite a recent consensus effort by the MRS community, literature comparing them is sparse but indicates a methodological bias. While invivo…

Medical Physics · Physics 2021-05-11 C. Jenkins , M. Chandler , F. C. Langbein , S. M. Shermer

Magnetic Resonance Spectroscopy (MRS) is a noninvasive tool to reveal metabolic information. One challenge of 1H-MRS is the low Signal-Noise Ratio (SNR). To improve the SNR, a typical approach is to perform Signal Averaging (SA) with M…

Objective: Magnetic Resonance Spectroscopy (MRS) is an important technique for biomedical detection. However, it is challenging to accurately quantify metabolites with proton MRS due to serious overlaps of metabolite signals, imperfections…

Magnetic resonance spectroscopy (MRS) is an established technique for studying tissue metabolism, particularly in central nervous system disorders. While powerful and versatile, MRS is often limited by challenges associated with data…

Quantitative Methods · Quantitative Biology 2024-08-29 Christopher J. Wu , Lawrence S. Kegeles , Jia Guo

Background: Magnetic resonance spectroscopy (MRS) enables non-invasive detection and measurement of biochemicals and metabolites. However, MRS has low signal-to-noise ratio (SNR) when concentrations of metabolites are in the range of the…

Medical Physics · Physics 2023-03-30 Jing Wang , Bing Ji , Yang Lei , Tian Liu , Hui Mao , Xiaofeng Yang

Magnetic resonance spectroscopy (MRS) is a non-invasive technique to measure the metabolic composition of tissues, offering valuable insights into neurological disorders, tumor detection, and other metabolic dysfunctions. However, accurate…

Machine Learning · Statistics 2025-05-09 Julian P. Merkofer , Dennis M. J. van de Sande , Alex A. Bhogal , Ruud J. G. van Sloun

Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging modality for measuring tissue metabolite levels in-vivo. An accurate estimation of spectral parameters allows for better assessment of spectral quality and metabolite…

Computer Vision and Pattern Recognition · Computer Science 2018-05-28 Dhritiman Das , Eduardo Coello , Rolf F Schulte , Bjoern H Menze

Nuclear Magnetic Resonance (NMR) spectra are widely used in metabolomics to obtain profiles of metabolites dissolved in biofluids such as cell supernatants. Methods for estimating metabolite concentrations from these spectra are presently…

Methodology · Statistics 2012-05-16 William Astle , Maria De Iorio , Sylvia Richardson , David Stephens , Timothy Ebbels

Nuclear magnetic resonance spectroscopy (MRS) allows for the determination of atomic structures and concentrations of different chemicals in a biochemical sample of interest. MRS is used in vivo clinically to aid in the diagnosis of several…

Medical Physics · Physics 2021-05-04 Zohaib Iqbal , Dan Nguyen , M. Albert Thomas , Steve Jiang

Detecting and quantifying products of cellular metabolism using Mass Spectrometry (MS) has already shown great promise in many biological and biomedical applications. The biggest challenge in metabolomics is annotation, where measured…

Machine Learning · Computer Science 2020-10-12 Hao Zhu , Liping Liu , Soha Hassoun

Robust machine learning for regulatory genomics is studied under biologically and technically induced distribution shifts. Deep convolutional and attention based models achieve strong in distribution performance on DNA regulatory sequence…

Genomics · Quantitative Biology 2026-02-20 Yiyao Yang

Magnetic resonance imaging (MRI) is critical for neurodevelopmental research, however access to high-field (HF) systems in low- and middle-income countries is severely hindered by their cost. Ultra-low-field (ULF) systems mitigate such…

Background: High-resolution MRI is critical for diagnosis, but long acquisition times limit clinical use. Super-resolution (SR) can enhance resolution post-scan, yet existing deep learning methods face fidelity-efficiency trade-offs.…

Two-dimensional electronic spectroscopy (2DES) has enabled significant discoveries in both biological and synthetic energy-transducing systems. Although deriving chemical information from 2DES is a complex task, machine learning (ML) offers…

Chemical Physics · Physics 2025-03-21 Jonathan D. Schultz , Kelsey A. Parker , Bashir Sbaiti , David N. Beratan

Objctives: This work aimed to statistically compare the metabolite quantification of human brain magnetic resonance spectroscopy (MRS) between the deep learning method QNet and the classical method LCModel through an easy-to-use intelligent…

The development of deep learning methods for magnetic resonance spectroscopy (MRS) is often hindered by limited availability of large, high-quality training datasets. While physics-based simulations are commonly used to mitigate this…

Multivariate analysis of fMRI data has benefited substantially from advances in machine learning. Most recently, a range of probabilistic latent variable models applied to fMRI data have been successful in a variety of tasks, including…

Simulated data is increasingly valued by researchers for validating MRS processing and analysis algorithms. However, there is no consensus on the optimal approaches for simulation models and parameters. This study introduces a novel MRS…

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