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The proliferation of Large Language Models (LLMs) and Intelligent Virtual Agents acting as psychotherapists presents significant opportunities for expanding mental healthcare access. However, their deployment has also been linked to serious…

Computation and Language · Computer Science 2025-09-23 Ian Steenstra , Timothy W. Bickmore

People experiencing severe distress increasingly use Large Language Model (LLM) chatbots as mental health support tools. Discussions on social media have described how engagements were lifesaving for some, but evidence suggests that…

Human-Computer Interaction · Computer Science 2025-05-12 Inhwa Song , Sachin R. Pendse , Neha Kumar , Munmun De Choudhury

The global mental health crisis is looming with a rapid increase in mental disorders, limited resources, and the social stigma of seeking treatment. As the field of artificial intelligence (AI) has witnessed significant advancements in…

Computation and Language · Computer Science 2023-11-27 Neo Christopher Chung , George Dyer , Lennart Brocki

Large Language Models (LLMs) are transforming mental health care by enhancing accessibility, personalization, and efficiency in therapeutic interventions. These AI-driven tools empower mental health professionals with real-time support,…

Computers and Society · Computer Science 2025-01-22 Hari Mohan Pandey

Large language models (LLMs) are already being piloted for clinical use in hospital systems like NYU Langone, Dana-Farber and the NHS. A proposed deployment use case is psychotherapy, where a LLM-powered chatbot can treat a patient…

Computation and Language · Computer Science 2024-10-10 Saadia Gabriel , Isha Puri , Xuhai Xu , Matteo Malgaroli , Marzyeh Ghassemi

Large language models (LLMs) have attracted significant attention for potential applications in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to evaluate the usage of LLMs…

Computers and Society · Computer Science 2024-08-14 Zhijun Guo , Alvina Lai , Johan Hilge Thygesen , Joseph Farrington , Thomas Keen , Kezhi Li

The past decade has been transformative for mental health research and practice. The ability to harness large repositories of data, whether from electronic health records (EHR), mobile devices, or social media, has revealed a potential for…

Computation and Language · Computer Science 2023-11-28 Munmun De Choudhury , Sachin R. Pendse , Neha Kumar

As AI systems become increasingly integrated into daily life, their potential to exacerbate or trigger severe psychological harms remains poorly understood and inadequately tested. This paper presents a proactive methodology for…

Human-Computer Interaction · Computer Science 2025-11-13 Chayapatr Archiwaranguprok , Constanze Albrecht , Pattie Maes , Karrie Karahalios , Pat Pataranutaporn

Large language models (LLMs) are increasingly used for mental health support, yet existing safety evaluations rely primarily on small, simulation-based test sets that have an unknown relationship to the linguistic distribution of real…

Computers and Society · Computer Science 2026-01-27 Caitlin A. Stamatis , Jonah Meyerhoff , Richard Zhang , Olivier Tieleman , Matteo Malgaroli , Thomas D. Hull

This study investigates the efficacy of Large Language Models (LLMs) in interactive language therapy for high-functioning autistic adolescents. With the rapid advancement of artificial intelligence, particularly in natural language…

Human-Computer Interaction · Computer Science 2023-11-17 Yujin Cho , Mingeon Kim , Seojin Kim , Oyun Kwon , Ryan Donghan Kwon , Yoonha Lee , Dohyun Lim

Amidst the growing interest in developing task-autonomous AI for automated mental health care, this paper addresses the ethical and practical challenges associated with the issue and proposes a structured framework that delineates levels of…

Computers and Society · Computer Science 2024-08-16 Declan Grabb , Max Lamparth , Nina Vasan

Large Language Models (LLMs) are increasingly deployed in mental health contexts, from structured therapeutic support tools to informal chat-based well-being assistants. While these systems increase accessibility, scalability, and…

Human-Computer Interaction · Computer Science 2025-10-14 Soraya S. Anvari , Rina R. Wehbe

Many people suffer from mental health problems but not everyone seeks professional help or has access to mental health care. AI chatbots have increasingly become a go-to for individuals who either have mental disorders or simply want…

Other Quantitative Biology · Quantitative Biology 2025-11-03 Aditya Naik , Jovi Thomas , Teja Sree Mandava , Himavanth Reddy Vemula

Large language models (LLMs) are increasingly explored as scalable tools for mental health counseling, yet evaluating their safety remains challenging due to the interactional and context-dependent nature of clinical harm. Existing…

Computation and Language · Computer Science 2026-04-21 Suhyun Lee , Palakorn Achananuparp , Neemesh Yadav , Ee-Peng Lim , Yang Deng

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

Large language models (LLMs) are increasingly utilized in healthcare applications. However, their deployment in clinical practice raises significant safety concerns, including the potential spread of harmful information. This study…

Cryptography and Security · Computer Science 2025-03-05 Hang Zhang , Qian Lou , Yanshan Wang

Large language models (LLMs) are increasingly used for emotional support and mental health-related interactions outside clinical settings, yet little is known about how people evaluate and relate to these systems in everyday use. We analyze…

Computation and Language · Computer Science 2026-01-29 Elham Aghakhani , Rezvaneh Rezapour

The rapid advancement of Large Language Models (LLMs), reasoning models, and agentic AI approaches coincides with a growing global mental health crisis, where increasing demand has not translated into adequate access to professional…

Human-Computer Interaction · Computer Science 2025-04-03 Kellie Yu Hui Sim , Kenny Tsu Wei Choo

Mental health remains a major public health concern, while access to timely psychological support is often limited. AI-based dialogue systems have emerged as promising tools to address these barriers, and recent advances in large language…

Computers and Society · Computer Science 2026-03-16 Daeun Lee , Dongje Yoo , Migyeong Yang , Jihyun An , Christine B. Cha , Jinyoung Han

Large Language Model (LLM) safeguards, which implement request refusals, have become a widely adopted mitigation strategy against misuse. At the intersection of adversarial machine learning and AI safety, safeguard red teaming has…

Cryptography and Security · Computer Science 2025-06-10 Zifan Wang , Christina Q. Knight , Jeremy Kritz , Willow E. Primack , Julian Michael
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