Related papers: SHARP: A compact focusing system for medical appli…
Targeted Alpha Therapy (TAT) has emerged as a promising modality for the treatment of various malignancies, leveraging the high linear energy transfer (LET) and short range of alpha particles to selectively irradiate cancer cells while…
The concept of dielectric-laser acceleration (DLA) provides the highest gradients among breakdown-limited (nonplasma) particle accelerators and thus the potential of miniaturization. The implementation of a fully scalable electron…
Over the past decade, optical wavefront shaping has been developed to focus light through highly opaque scattering layers, opening new possibilities for biomedical applications. To probe light intensity deep inside soft scattering media…
With the purpose to devise a novel lasing scheme, we consider a two level system with both a transversal and longitudinal coupling to the electromagnetic field. If the longitudinal coupling is sufficiently strong, multi-photon transitions…
Today's high-power laser systems are capable of reaching photon intensities up to $10^{22}$ W/cm^2, generating plasmas when interacting with material. The high intensity and ultrashort laser pulse duration (fs) make direct observation of…
Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…
Confocal Raman microscopy, a highly specific and label-free technique for the microscale study of thick samples, often presents difficulties due to weak Raman signals. Inhomogeneous samples introduce wavefront aberrations that further…
We propose a new method for laser pulse compression that uses the spatially varying dispersion of a plasma plume with a density gradient. This novel scheme can be used to compress ultrahigh power lasers. A long, negatively…
A laser is not necessarily a sophisticated device: Pumping energy into an amplifying medium randomly filled with scatterers, a powder for instance, makes a perfect "random laser." In such a laser, the absence of mirrors greatly simplifies…
A hollow cylindrical micron-scale structure is proposed to enhance and manipulate the laser plasma interaction. It is shown through 3-D particle-in-cell simulations that the incident laser pulse intensity is enhanced within the tube. A…
We demonstrate a tandem lens optical setup, comprising two diffractive optics, that focuses a high-power ultrafast laser with a shaped on-axis intensity profile, producing a meter-long Bessel focus. The intended use of the optical setup is…
An emission tomography of laser-induced plasmas employed in the laser induced breakdown spectroscopy (LIBS) requires long signal integration times during which the plasma cannot be considered stationary. To reduce the integration time, it…
In recent years, the concept of high-gradient, symmetric focusing using active plasma lenses has regained notable attention owing to its potential benefits in terms of compactness and beam dynamics when juxtaposed with traditional focusing…
The development of effective focusing schemes for positron bunches in plasma accelerators remains a significant challenge, as nonlinear regimes fail to create stable focusing channels for positrons. This work presents a method for focusing…
Radiologists rely on anatomical understanding to accurately delineate pathologies, yet most current deep learning approaches use pure pattern recognition and ignore the anatomical context in which pathologies develop. To narrow this gap, we…
Particle therapy is a well established clinical treatment of tumors. More than one hundred particle therapy centers are in operation world wide. The advantage of using hadrons like protons or carbon ions as particles for tumor irradiation…
Laser-plasma instabilities under ignition conditions for direct-drive inertial confinement fusion are studied using two-dimensional Particle-in-Cell simulations with a combination of in-plane (PP) and out-of-the-plane (SP) lasers. The…
Wavefront shaping systems aim to image deep into scattering tissue by reshaping incoming and outgoing light to correct aberrations caused by tissue inhomogeneity However, the desired modulation depends on the unknown tissue structure and…
Percutaneous radiofrequency ablation (RFA) is a minimally invasive technique that destroys cancer cells by heat. The heat results from focusing energy in the radiofrequency spectrum through a needle. Amongst others, this can enable the…
Surface plasmon resonance (SPR) has been intensively studied and widely employed for light trapping and absorption enhancement. In the mid-infrared and terahertz (THz) regime, graphene supports the tunable SPR via manipulating its Fermi…