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We consider the evolution of large but finite populations on arbitrary fitness landscapes. We describe the evolutionary process by a Markov, Moran process. We show that to $\mathcal O(1/N)$, the time-averaged fitness is lower for the finite…

Populations and Evolution · Quantitative Biology 2015-06-04 Dirk M. Lorenz , Jeong-Man Park , Michael W. Deem

We study the equilibrium behaviour of a deterministic four-state mutation-selection model as a model for the evolution of a population of nucleotide sequences in sequence space. The mutation model is the Kimura 3ST mutation scheme, and the…

Biological Physics · Physics 2007-05-23 Tini Garske , Uwe Grimm

Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. For the trait under evolutionary selection (`fitness'), measured values over all possible combinations of a set of mutations yield…

Populations and Evolution · Quantitative Biology 2015-05-27 Jasper Franke , Alexander Klözer , J. Arjan G. M. de Visser , Joachim Krug

This is an introductory review of deterministic mutation-selection models for asexual populations (i.e., quasispecies theory) and related topics. First, the basic concepts of fitness, mutations, and sequence space are introduced. Different…

Populations and Evolution · Quantitative Biology 2007-07-26 Kavita Jain , Joachim Krug

When evolution algorithms are used to unfold the neutron energy spectrum, fitness function design is an important fundamental work for evaluating the quality of the solution, but it has not attracted much attention. In this work, we…

Neural and Evolutionary Computing · Computer Science 2021-02-03 Rui Li , Jianbo Yang , Xianguo Tuo , Rui Shi

In the area of evolutionary computation the calculation of diverse sets of high-quality solutions to a given optimization problem has gained momentum in recent years under the term evolutionary diversity optimization. Theoretical insights…

Neural and Evolutionary Computing · Computer Science 2021-04-28 Jakob Bossek , Frank Neumann

We review and extend results for mutation, selection, genetic drift, and migration in a one-dimensional continuous population. The population is described by a continuous limit of the stepping stone model, which leads to the stochastic…

Populations and Evolution · Quantitative Biology 2011-04-14 K. S. Korolev , Mikkel Avlund , Oskar Hallatschek , David R. Nelson

Recent theoretical research has shown that self-adjusting and self-adaptive mechanisms can provably outperform static settings in evolutionary algorithms for binary search spaces. However, the vast majority of these studies focuses on…

Neural and Evolutionary Computing · Computer Science 2020-06-03 Amirhossein Rajabi , Carsten Witt

Evolutionary algorithms are sensitive to the mutation rate (MR); no single value of this parameter works well across domains. Self-adaptive MR approaches have been proposed but they tend to be brittle: Sometimes they decay the MR to zero,…

Neural and Evolutionary Computing · Computer Science 2022-04-12 Akarsh Kumar , Bo Liu , Risto Miikkulainen , Peter Stone

Evolutionary algorithms (EAs) are general-purpose problem solvers that usually perform an unbiased search. This is reasonable and desirable in a black-box scenario. For combinatorial optimization problems, often more knowledge about the…

Neural and Evolutionary Computing · Computer Science 2020-04-23 Vahid Roostapour , Jakob Bossek , Frank Neumann

The most common representation in evolutionary computation are bit strings. This is ideal to model binary decision variables, but less useful for variables taking more values. With very little theoretical work existing on how to use…

Neural and Evolutionary Computing · Computer Science 2016-04-13 Benjamin Doerr , Carola Doerr , Timo Kötzing

We present a novel approach to performing fitness approximation in genetic algorithms (GAs) using machine-learning (ML) models, through dynamic adaptation to the evolutionary state. Maintaining a dataset of sampled individuals along with…

Neural and Evolutionary Computing · Computer Science 2024-05-22 Itai Tzruia , Tomer Halperin , Moshe Sipper , Achiya Elyasaf

An evolutionary algorithm (EA) is developed as an alternative to the EM algorithm for parameter estimation in model-based clustering. This EA facilitates a different search of the fitness landscape, i.e., the likelihood surface, utilizing…

Computation · Statistics 2020-06-09 Sharon M. McNicholas , Paul D. McNicholas , Daniel A. Ashlock

Which factors govern the evolution of mutation rates and emergence of species? Here, we address this question using a first principles model of life where population dynamics of asexual organisms is coupled to molecular properties and…

Populations and Evolution · Quantitative Biology 2009-11-13 Muyoung Heo , Louis Kang , Eugene I. Shakhnovich

This paper explores the enhancement of solution diversity in evolutionary algorithms (EAs) for the maximum matching problem, concentrating on complete bipartite graphs and paths. We adopt binary string encoding for matchings and use Hamming…

Neural and Evolutionary Computing · Computer Science 2024-04-19 Jonathan Gadea Harder , Aneta Neumann , Frank Neumann

The common understanding of protein evolution has been that neutral or slightly deleterious mutations are fixed by random drift, and evolutionary rate is determined primarily by the proportion of neutral mutations. However, recent studies…

Populations and Evolution · Quantitative Biology 2015-12-31 Sanzo Miyazawa

Differential Evolution (DE) is quite powerful for real parameter single objective optimization. However, the ability of extending or changing search area when falling into a local optimum is still required to be developed in DE for…

Artificial Intelligence · Computer Science 2020-03-03 Chengjun Li , Yang Li

While most theoretical run time analyses of discrete randomized search heuristics provide bounds on the expected number of evaluations to find the global optimum, we consider the anytime performance of evolutionary and…

Neural and Evolutionary Computing · Computer Science 2026-04-09 Timo Kötzing , Jurek Sander

This work presents a population genetic model of evolution, which includes haploid selection, mutation, recombination, and drift. The mutation-selection equilibrium can be expressed exactly in closed form for arbitrary fitness functions…

Populations and Evolution · Quantitative Biology 2023-02-28 Jenny M. Poulton , Lee Altenberg , Chris Watkins

We investigate a model of evolutionary dynamics on a smooth landscape which features a ``mutator'' allele whose effect is to increase the mutation rate. We show that the expected proportion of mutators far from equilibrium, when the fitness…

patt-sol · Physics 2009-10-30 David A. Kessler , Herbert Levine
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