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The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Junjie Zhou , Jiao Tang , Yingli Zuo , Peng Wan , Daoqiang Zhang , Wei Shao

Accurate survival prediction in Non-Small Cell Lung Cancer (NSCLC) requires integrating clinical, radiological, and histopathological data. Multimodal Deep Learning (MDL) can improve precision prognosis, but small cohorts and missing…

Accurate prognosis of non-small cell lung cancer (NSCLC) patients undergoing immunotherapy is essential for personalized treatment planning, enabling informed patient decisions, and improving both treatment outcomes and quality of life.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Qilong Xing , Zikai Song , Bingxin Gong , Lian Yang , Junqing Yu , Wei Yang

Integrating the different data modalities of cancer patients can significantly improve the predictive performance of patient survival. However, most existing methods ignore the simultaneous utilization of rich semantic features at different…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Liangrui Pan , Yijun Peng , Yan Li , Yiyi Liang , Liwen Xu , Qingchun Liang , Shaoliang Peng

Survival prediction for esophageal squamous cell cancer (ESCC) is crucial for doctors to assess a patient's condition and tailor treatment plans. The application and development of multi-modal deep learning in this field have attracted…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Chengyu Wu , Yatao Zhang , Yaqi Wang , Qifeng Wang , Shuai Wang

Accurate survival prediction is critical in oncology for prognosis and treatment planning. Traditional approaches often rely on a single data modality, limiting their ability to capture the complexity of tumor biology. To address this…

Machine Learning · Computer Science 2025-07-11 Alba Garrido , Alejandro Almodóvar , Patricia A. Apellániz , Juan Parras , Santiago Zazo

Survival analysis, as a challenging task, requires integrating Whole Slide Images (WSIs) and genomic data for comprehensive decision-making. There are two main challenges in this task: significant heterogeneity and complex inter- and…

Image and Video Processing · Electrical Eng. & Systems 2024-06-17 Conghao Xiong , Hao Chen , Hao Zheng , Dong Wei , Yefeng Zheng , Joseph J. Y. Sung , Irwin King

Cancer prognosis and survival outcome predictions are crucial for therapeutic response estimation and for stratifying patients into various treatment groups. Medical domains concerned with cancer prognosis are abundant with multiple…

Image and Video Processing · Electrical Eng. & Systems 2024-02-29 Ruining Deng , Nazim Shaikh , Gareth Shannon , Yao Nie

Multimodal variational autoencoders (VAEs) have emerged as a powerful framework for survival risk modeling in multiple myeloma by integrating heterogeneous omics and clinical data. However, when trained under survival supervision, standard…

Machine Learning · Computer Science 2026-04-09 Zixuan Chen , Heng Zhang , YuPeng Qin , WenPeng Xing , Qiang Wang , Da Wang , Changting Lin , Meng Han

Missing input sequences are common in medical imaging data, posing a challenge for deep learning models reliant on complete input data. In this work, inspired by MultiMAE [2], we develop a masked autoencoder (MAE) paradigm for multi-modal,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Ayhan Can Erdur , Christian Beischl , Daniel Scholz , Jiazhen Pan , Benedikt Wiestler , Daniel Rueckert , Jan C Peeken

In large studies involving multi protocol Magnetic Resonance Imaging (MRI), it can occur to miss one or more sub-modalities for a given patient owing to poor quality (e.g. imaging artifacts), failed acquisitions, or hallway interrupted…

Image and Video Processing · Electrical Eng. & Systems 2021-07-09 Mohammad Hamghalam , Alejandro F. Frangi , Baiying Lei , Amber L. Simpson

Accurate survival prediction from multimodal medical data is essential for precision oncology, yet clinical deployment faces a persistent challenge: modalities are frequently incomplete due to cost constraints, technical limitations, or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Kyungwon Kim , Dosik Hwang

Survival prediction of cancers is crucial for clinical practice, as it informs mortality risks and influences treatment plans. However, a static model trained on a single dataset fails to adapt to the dynamically evolving clinical…

Machine Learning · Computer Science 2026-01-21 Dianzhi Yu , Conghao Xiong , Yankai Chen , Wenqian Cui , Xinni Zhang , Yifei Zhang , Hao Chen , Joseph J. Y. Sung , Irwin King

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

Methodology · Statistics 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon

The use of diverse modalities, such as omics, medical images, and clinical data can not only improve the performance of prognostic models but also deepen an understanding of disease mechanisms and facilitate the development of novel…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Maria Boyko , Aleksandra Beliaeva , Dmitriy Kornilov , Alexander Bernstein , Maxim Sharaev

Survival prediction is a crucial task associated with cancer diagnosis and treatment planning. This paper presents a novel approach to survival prediction by harnessing comprehensive information from CT and PET scans, along with associated…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Aiman Farooq , Deepak Mishra , Santanu Chaudhury

Multi-label classification (MLC) is a prediction task where each sample can have more than one label. We propose a novel contrastive learning boosted multi-label prediction model based on a Gaussian mixture variational autoencoder…

Machine Learning · Computer Science 2022-06-13 Junwen Bai , Shufeng Kong , Carla P. Gomes

Learning latent representations that are simultaneously expressive, geometrically well-structured, and reliably calibrated remains a central challenge for Variational Autoencoders (VAEs). Standard VAEs typically assume a diagonal Gaussian…

Machine Learning · Computer Science 2025-12-02 Mehmet Can Yavuz

With the ever-increasing amount of data, the central challenge in multimodal learning involves limitations of labelled samples. For the task of classification, techniques such as meta-learning, zero-shot learning, and few-shot learning…

Computer Vision and Pattern Recognition · Computer Science 2021-06-29 Nihar Bendre , Kevin Desai , Peyman Najafirad

Survival analysis stands as a pivotal process in cancer treatment research, crucial for predicting patient survival rates accurately. Recent advancements in data collection techniques have paved the way for enhancing survival predictions by…

Machine Learning · Computer Science 2024-07-26 Linhao Qu , Dan Huang , Shaoting Zhang , Xiaosong Wang
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