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Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that…

The Genomic Foundation Model (GFM) paradigm is expected to facilitate the extraction of generalizable representations from massive genomic data, thereby enabling their application across a spectrum of downstream applications. Despite…

Genomics · Quantitative Biology 2024-06-06 Zicheng Liu , Jiahui Li , Siyuan Li , Zelin Zang , Cheng Tan , Yufei Huang , Yajing Bai , Stan Z. Li

Minority sampling aims to generate low-density instances on a data manifold and is of central importance in applications such as medical diagnosis, anomaly detection, and creative AI. Existing approaches, however, define minority samples…

Machine Learning · Computer Science 2026-05-26 Sol Park , Soobin Um

We present Clin-JEPA, a multi-phase co-training framework for joint-embedding predictive (JEPA) pretraining on EHR patient trajectories. JEPA architectures have enabled latent-space planning in robotics and high-quality representation…

World models require robust relational understanding to support prediction, reasoning, and control. While object-centric representations provide a useful abstraction, they are not sufficient to capture interaction-dependent dynamics. We…

Artificial Intelligence · Computer Science 2026-05-29 Heejeong Nam , Quentin Le Lidec , Lucas Maes , Yann LeCun , Randall Balestriero

Predicting molecular properties is a critical component of drug discovery. Recent advances in deep learning, particularly Graph Neural Networks (GNNs), have enabled end-to-end learning from molecular structures, reducing reliance on manual…

Computation and Language · Computer Science 2025-09-26 Peng Zhou , Lai Hou Tim , Zhixiang Cheng , Kun Xie , Chaoyi Li , Wei Liu , Xiangxiang Zeng

Current genomic foundation models (GFMs) rely on extensive neural computation to implicitly approximate conserved biological motifs from single-nucleotide inputs. We propose Gengram, a conditional memory module that introduces an explicit…

Advancements in machine learning for molecular property prediction have improved accuracy but at the expense of higher computational cost and longer training times. Recently, the Joint Multi-domain Pre-training (JMP) foundation model has…

Machine Learning · Computer Science 2025-04-29 Yasir Ghunaim , Andrés Villa , Gergo Ignacz , Gyorgy Szekely , Motasem Alfarra , Bernard Ghanem

Sentence Embedding stands as a fundamental task within the realm of Natural Language Processing, finding extensive application in search engines, expert systems, and question-and-answer platforms. With the continuous evolution of large…

Computation and Language · Computer Science 2024-05-16 Bowen Zhang , Kehua Chang , Chunping Li

Joint Embedding Predictive Architectures (JEPA) have emerged as a powerful framework for learning general-purpose representations. However, these models often lack interpretability and suffer from inefficiencies due to dense embedding…

Machine Learning · Computer Science 2025-04-24 Max Hartman , Lav Varshney

Despite recent progress in time-series foundation models, challenges persist in improving representation learning and adapting to diverse downstream tasks. We introduce a General Time-series Model (GTM), which advances representation…

Machine Learning · Computer Science 2026-03-13 Cheng He , Xu Huang , Gangwei Jiang , Zhaoyi Li , Defu Lian , Hong Xie , Enhong Chen , Xijie Liang , Zengrong Zheng , Patrick P. C. Lee

Aerodynamic surrogate models are increasingly used to replace repeated high-fidelity CFD evaluations in many-query design settings, but current approaches still face two important limitations: they often scale poorly to the very large…

DNA language model aims to decipher the regulatory grammar and semantic of genomes by capturing long range dependencies in DNA sequences. Existing methods emphasize long range token interactions but often ignore the interplay between local…

Artificial Intelligence · Computer Science 2026-05-08 Weihua Wang , Haoji Li , Feilong Bao , Lei Yang , Guanglai Gao

Learning predictive world models from unlabelled video is a foundational challenge in artificial intelligence. While Joint Embedding Predictive Architectures (JEPA) have set new benchmarks in semantic classification, they often remain…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Santosh Kumar Paidi

Decision trees are a crucial class of models offering robust predictive performance and inherent interpretability across various domains, including healthcare, finance, and logistics. However, current tree induction methods often face…

Machine Learning · Computer Science 2025-03-19 Tennison Liu , Nicolas Huynh , Mihaela van der Schaar

Continuous Glucose Monitoring (CGM) can detect early metabolic subphenotypes (insulin resistance, IR; $\beta$-cell dysfunction), but population-scale deployment faces two coupled problems. First, the same physiological state appears through…

Machine Learning · Computer Science 2026-05-05 Hada Melino Muhammad , Zechen Li , Flora Salim , Ahmed A. Metwally

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

This paper focuses on multimodal alignment within the realm of Artificial Intelligence, particularly in text and image modalities. The semantic gap between the textual and visual modality poses a discrepancy problem towards the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Khang H. N. Vo , Duc P. T. Nguyen , Thong Nguyen , Tho T. Quan

Joint-Embedding Predictive Architectures (JEPAs) aim to learn representations by predicting target embeddings from context embeddings, inducing a scalar compatibility energy in a latent space. In contrast, Quasimetric Reinforcement Learning…

Machine Learning · Computer Science 2026-02-13 Anthony Kobanda , Waris Radji

Recent advancements in self-supervised learning in the point cloud domain have demonstrated significant potential. However, these methods often suffer from drawbacks, including lengthy pre-training time, the necessity of reconstruction in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Ayumu Saito , Prachi Kudeshia , Jiju Poovvancheri
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