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Related papers: JEPA-DNA: Grounding Genomic Foundation Models thro…

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Joint-Embedding Predictive Architecture (JEPA) has emerged as a promising self-supervised approach that learns by leveraging a world model. While previously limited to predicting missing parts of an input, we explore how to generalize the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-04 Quentin Garrido , Mahmoud Assran , Nicolas Ballas , Adrien Bardes , Laurent Najman , Yann LeCun

As Large Language Models (LLMs) achieve increasingly sophisticated performance on complex reasoning tasks, current architectures serve as critical proxies for the internal heuristics of frontier models. Characterizing emergent reasoning is…

Artificial Intelligence · Computer Science 2026-03-31 Rohan Pandey , Eric Ye , Michael Li

Event cameras provide robust visual signals under fast motion and challenging illumination conditions thanks to their microsecond latency and high dynamic range. However, their unique sensing characteristics and limited labeled data make it…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Jianwen Cao , Jiaxu Xing , Nico Messikommer , Davide Scaramuzza

Genomic language models (gLMs) hold promise for generating novel, functional DNA sequences for synthetic biology. However, realizing this potential requires models to go beyond evolutionary plausibility and understand how DNA sequence…

Quantitative Methods · Quantitative Biology 2025-08-27 Shiyu Jiang , Xuyin Liu , Zitong Jerry Wang

Multivariate time series underpin modern critical infrastructure, making the prediction of anomalies a vital necessity for proactive risk mitigation. While Joint-Embedding Predictive Architectures (JEPA) offer a promising framework for…

Machine Learning · Computer Science 2026-02-05 Yanan He , Yunshi Wen , Xin Wang , Tengfei Ma

The success of foundation AI has motivated the research of circuit foundation models, which are customized to assist the integrated circuit (IC) design process. However, existing pre-trained circuit foundation models are typically limited…

Machine Learning · Computer Science 2025-08-07 Wenji Fang , Jing Wang , Yao Lu , Shang Liu , Zhiyao Xie

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

Large Language Models (LLMs) demonstrate remarkable generalizability across diverse tasks, yet genomic foundation models (GFMs) still require separate finetuning for each downstream application, creating significant overhead as model sizes…

Genomics · Quantitative Biology 2025-02-07 Zehui Li , Vallijah Subasri , Yifei Shen , Dongsheng Li , Yiren Zhao , Guy-Bart Stan , Caihua Shan

Language representation learning has emerged as a promising approach for sequential recommendation, thanks to its ability to learn generalizable representations. However, despite its advantages, this approach still struggles with data…

Information Retrieval · Computer Science 2025-08-08 Minh-Anh Nguyen , Dung D. Le

Foundation models in genomics have shown mixed success compared to their counterparts in natural language processing. Yet, the reasons for their limited effectiveness remain poorly understood. In this work, we investigate the role of…

Machine Learning · Computer Science 2026-04-07 Maxime Rochkoulets , Lovro Vrček , Mile Šikić

Semi-supervised learning has emerged as a powerful paradigm for leveraging large amounts of unlabeled data to improve the performance of machine learning models when labeled data are scarce. Among existing approaches, methods derived from…

Machine Learning · Computer Science 2026-04-29 Ali Aghababaei-Harandi , Aude Sportisse , Massih-Reza Amini

Generative models, from diffusion models to large language models, achieve remarkable performance but at a cost in training data orders of magnitude larger than what biological learners require. An alternative paradigm has emerged in which…

Machine Learning · Computer Science 2026-05-28 Daniel J. Korchinski , Alessandro Favero , Matthieu Wyart

Manifold learning methods are an invaluable tool in today's world of increasingly huge datasets. Manifold learning algorithms can discover a much lower-dimensional representation (embedding) of a high-dimensional dataset through non-linear…

Machine Learning · Computer Science 2021-08-24 Andrew Lensen , Bing Xue , Mengjie Zhang

We introduce LatentTimePFN (LaT-PFN), a foundational Time Series model with a strong embedding space that enables zero-shot forecasting. To achieve this, we perform in-context learning in latent space utilizing a novel integration of the…

Machine Learning · Computer Science 2024-05-24 Stijn Verdenius , Andrea Zerio , Roy L. M. Wang

We present a transformer architecture-based foundation model for tasks at high-energy particle colliders such as the Large Hadron Collider. We train the model to classify jets using a self-supervised strategy inspired by the Joint Embedding…

Machine Learning · Computer Science 2025-02-07 Jai Bardhan , Radhikesh Agrawal , Abhiram Tilak , Cyrin Neeraj , Subhadip Mitra

Accurate diagnosis of heart arrhythmias requires the interpretation of electrocardiograms (ECG), which capture the electrical activity of the heart. Automating this process through machine learning is challenging due to the need for large…

Signal Processing · Electrical Eng. & Systems 2024-10-21 Kuba Weimann , Tim O. F. Conrad

Large language models (LLMs) have revolutionized natural language processing and are increasingly applied to other sequential data types, including genetic sequences. However, adapting LLMs to genomics presents significant challenges.…

Machine Learning · Computer Science 2025-10-29 Qihao Duan , Bingding Huang , Zhenqiao Song , Irina Lehmann , Lei Gu , Roland Eils , Benjamin Wild

Learning manipulable representations of the world and its dynamics is central to AI. Joint-Embedding Predictive Architectures (JEPAs) offer a promising blueprint, but lack of practical guidance and theory has led to ad-hoc R&D. We present a…

Machine Learning · Computer Science 2025-11-17 Randall Balestriero , Yann LeCun

Large-scale language models such as DNABert and LOGO aim to learn optimal gene representations and are trained on the entire Human Reference Genome. However, standard tokenization schemes involve a simple sliding window of tokens like…

Computation and Language · Computer Science 2023-10-16 Soumyadeep Roy , Jonas Wallat , Sowmya S Sundaram , Wolfgang Nejdl , Niloy Ganguly

Joint Embedding Predictive Architectures (JEPAs) offer a compelling framework for learning world models in compact latent spaces, yet existing methods remain fragile, relying on complex multi-term losses, exponential moving averages,…

Machine Learning · Computer Science 2026-03-26 Lucas Maes , Quentin Le Lidec , Damien Scieur , Yann LeCun , Randall Balestriero