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Irreversible thermodynamics of single-molecule experiments subject to external constraining forces of a mechanical nature is presented. Extending Onsager's formalism to the non-linear case of systems under non-equilibrium external…

Biological Physics · Physics 2016-10-31 I. Santamaria-Holek , N. J. Lopez-Alamilla , M. Hidalgo-Soria , A. Perez-Madrid

Minimal models of self-propelled particles with short-range volume exclusion interactions have been shown to exhibit signatures of phase separation. Here I show that the observed interfacial stability and fluctuations in motility-induced…

Soft Condensed Matter · Physics 2017-01-11 Chiu Fan Lee

Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliably achieved through an assembly line with a specific…

Biological Physics · Physics 2022-03-23 Tyler S. Harmon , Frank Jülicher

We investigate the steady-state and dynamical properties of a reciprocal many-body system consisting of self-propelled active particles with local alignment interactions that exists within a fan-shaped neighborhood of each particle. We find…

Statistical Mechanics · Physics 2022-07-07 Wei-chen Guo , Zuo Wang , Pei-fang Wu , Li-jun Lang , Bao-quan Ai , Liang He

Homogeneous active Brownian particle (ABP) systems with purely repulsive interactions are considered to have simple phase behavior, but various physical attributes of active entities can lead to variation in the collective dynamics. Recent…

Soft Condensed Matter · Physics 2025-06-03 Monika Sanoria , Raghunath Chelakkot , Amitabha Nandi

We theoretically study mixtures of chemically-interacting particles, which produce or consume a chemical to which they are attracted or repelled, in the most general case of many coexisting species. We find a new class of active phase…

Soft Condensed Matter · Physics 2019-07-15 Jaime Agudo-Canalejo , Ramin Golestanian

Recent advances in micro- and nano-technologies allow the construction of complex active systems from biological and synthetic materials. An interesting example is active vesicles, which consist of a membrane enclosing self-propelled…

Soft Condensed Matter · Physics 2024-06-04 Priyanka Iyer , Gerhard Gompper , Dmitry A. Fedosov

Self-powered motion in catalytic colloidal particles provides a compelling example of active matter, i.e. systems that engage in single-particle and collective behavior far from equilibrium. The long-time, long-distance behavior of such…

Soft Condensed Matter · Physics 2017-10-25 Young-Moo Byun , Paul E. Lammert , Yiying Hong , Ayusman Sen , Vincent H. Crespi

Proliferation and motility are ubiquitous drivers of activity in biological systems. Here, we study a dense binary mixture of motile and proliferating particles with exclusively repulsive interactions, where homeostasis in the proliferating…

Soft Condensed Matter · Physics 2025-06-11 Lukas Hupe , Joanna M. Materska , David Zwicker , Ramin Golestanian , Bartlomiej Waclaw , Philip Bittihn

We study numerically the phases and dynamics of a dense collection of self-propelled particles with soft repulsive interactions in two dimensions. The model is motivated by recent in vitro experiments on confluent monolayers of migratory…

Soft Condensed Matter · Physics 2015-05-28 Silke Henkes , Yaouen Fily , M. Cristina Marchetti

Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which…

Biological Physics · Physics 2008-03-07 Debashish Chowdhury

In equilibrium, the physical properties of matter are set by the interactions between the constituents. In contrast, the energy input of the individual components controls the behavior of synthetic or living active matter. Great progress…

Soft Condensed Matter · Physics 2025-08-29 Q. Martinet , Y. Li , A. Aubret , E. Hannezo , J. Palacci

We present a model of active particles interacting through a dynamic, heterogeneous environment, leading to emergent collective behaviors without direct agent-to-agent communication. Expanding the resource-dependent framework introduced in…

Biological Physics · Physics 2026-01-22 Gaston Briozzo , Gustavo J. Sibona , Fernando Peruani

We investigate the phase behavior and kinetics of a monodisperse mixture of active (\textit{i.e.}, self-propelled) and passive isometric Brownian particles through Brownian dynamics simulations and theory. As in a purely active system,…

Soft Condensed Matter · Physics 2015-01-08 Joakim Stenhammar , Raphael Wittkowski , Davide Marenduzzo , Michael E. Cates

Living systems routinely consume energy to achieve motility, often using intricate biomolecular machinery. In this work, we show that active droplets can sustain indefinite self-propulsion of a spherical colloid in an otherwise homogeneous,…

Soft Condensed Matter · Physics 2026-05-01 Benjamin Sorkin , Ned S. Wingreen

The structural dynamics of macromolecules is important for most microbiological processes, from protein folding to the origins of neurodegenerative disorders. Noninvasive measurements of these dynamics are highly challenging. Recently,…

We examine motility-induced phase separation (MIPS) in two-dimensional run and tumble disk systems using both machine learning and noise fluctuation analysis. Our measures suggest that within the MIPS state there are several distinct…

Soft Condensed Matter · Physics 2024-04-23 D. McDermott , C. Reichhardt , C. J. O. Reichhardt

The transport of macromolecules, such as DNA, through the cytoskeleton is critical to wide-ranging cellular processes from cytoplasmic streaming to transcription. The rigidity and steric hindrances imparted by the network of filaments…

Active colloids exhibit persistent motion, which can lead to motility-induced phase separation (MIPS). However, there currently exists no microscopic theory to account for this phenomenon. We report a first-principles theory, free of fit…

Soft Condensed Matter · Physics 2015-06-24 T. F. F. Farage , P. Krinninger , J. M. Brader

We propose a mechanism to control the formation of stable obstructions in two-dimensional micro-channels of variable sections taking advantage of the peculiar clustering property of active systems. Under the activation of the…

Soft Condensed Matter · Physics 2021-01-04 Lorenzo Caprini , Fabio Cecconi , Claudio Maggi , Umberto Marini Bettolo Marconi