Molecular Assembly Lines in Active Droplets
Biological Physics
2022-03-23 v1 Soft Condensed Matter
Statistical Mechanics
Abstract
Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliably achieved through an assembly line with a specific sequence of assembly steps. Using droplet interfaces to position compartment boundaries, we show that an assembly line can be self organized by active droplets. As a consequence, assembly steps can be arranged spatially so that a specific order of assembly is achieved and incorrect assembly is strongly suppressed.
Cite
@article{arxiv.2103.09886,
title = {Molecular Assembly Lines in Active Droplets},
author = {Tyler S. Harmon and Frank Jülicher},
journal= {arXiv preprint arXiv:2103.09886},
year = {2022}
}