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Rapid progress in computational pathology is increasingly driven by vision foundation models pretrained on vast histopathology datasets. While recent efforts have prioritized training on an ever-larger amount of patches, we take an…

The scaling laws and extraordinary performance of large foundation models motivate the development and utilization of such models in biomedicine. However, despite early promising results on some biomedical benchmarks, there are still major…

Representation learning from Gigapixel Whole Slide Images (WSI) poses a significant challenge in computational pathology due to the complicated nature of tissue structures and the scarcity of labeled data. Multi-instance learning methods…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Ali Nasiri-Sarvi , Vincent Quoc-Huy Trinh , Hassan Rivaz , Mahdi S. Hosseini

Pathology foundation models (PFMs) have emerged as powerful pretrained encoders for computational pathology, but their robustness under clinically relevant distribution shifts remains insufficiently understood. We benchmark the robustness…

Image and Video Processing · Electrical Eng. & Systems 2026-04-29 Fredrik K. Gustafsson , Mattias Rantalainen

Automated analysis of optical coherence tomography (OCT) and OCT angiography (OCTA) images is critical for robust ophthalmic diagnosis. Existing mainstream methods trained from scratch rely heavily on massive data and model scale, thereby…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Xiaofei Su , Zengshuo Wang , Minghe Sun , Xin Zhao , Mingzhu Sun

Large language models (LLMs) deliver impressive performance but incur prohibitive memory and compute costs at deployment. Model pruning is an effective way to reduce these overheads, yet existing approaches face challenges: unstructured…

Machine Learning · Computer Science 2026-04-30 Younes Hourri , Mohammad Mozaffari , Maryam Mehri Dehnavi

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…

Recent advances in artificial intelligence (AI), in particular self-supervised learning of foundation models (FMs), are revolutionizing medical imaging and computational pathology (CPath). A constant challenge in the analysis of digital…

Foundation models for medical imaging demonstrate superior generalization capabilities across diverse anatomical structures and clinical applications. Their outstanding performance relies on substantial computational resources, limiting…

Image and Video Processing · Electrical Eng. & Systems 2026-04-15 Chen Ma , Jing Jiao , Shuyu Liang , Junhu Fu , Qin Wang , Zeju Li , Yuanyuan Wang , Yi Guo

Pathology foundation models (FMs) have driven significant progress in computational pathology. However, these high-performing models can easily exceed a billion parameters and produce high-dimensional embeddings, thus limiting their…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Christian Grashei , Christian Brechenmacher , Rao Muhammad Umer , Jingsong Liu , Carsten Marr , Ewa Szczurek , Peter J. Schüffler

Computational pathology (CPath) digitizes pathology slides into whole slide images (WSIs), enabling analysis for critical healthcare tasks such as cancer diagnosis and prognosis. However, WSIs possess extremely long sequence lengths (up to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Wenhao Tang , Heng Fang , Ge Wu , Xiang Li , Ming-Ming Cheng

The rapid generation of whole-slide images (WSIs) in dermatopathology necessitates automated methods for efficient processing and accurate classification. This study evaluates the performance of two foundation models, UNI and Virchow2, as…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Riya Gupta , Yiwei Zong , Dennis H. Murphree

This survey delves into the realm of Parameter-Efficient Fine-Tuning (PEFT) within the context of Foundation Models (FMs). PEFT, a cost-effective fine-tuning technique, minimizes parameters and computational complexity while striving for…

Computation and Language · Computer Science 2025-01-24 Dan Zhang , Tao Feng , Lilong Xue , Yuandong Wang , Yuxiao Dong , Jie Tang

Despite being widely used to support clinical care, general-purpose large multimodal models (LMMs) have generally shown poor or inconclusive performance in medical image interpretation, particularly in pathology, where gigapixel images are…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Thomas A. Buckley , Kian R. Weihrauch , Katherine Latham , Andrew Z. Zhou , Padmini A. Manrai , Arjun K. Manrai

Parameter-efficient fine-tuning (PEFT) allows model builders to capture the task-specific parameters into adapters, which are a fraction of the size of the original base model. Popularity of PEFT technique for fine-tuning has led to the…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-24 Saransh Gupta , Umesh Deshpande , Travis Janssen , Swami Sundararaman

In recent years, diffusion models have demonstrated remarkable success in high-fidelity image synthesis. However, fine-tuning these models for specialized domains, such as medical imaging, remains challenging due to limited domain-specific…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Ruchir Namjoshi , Nagasai Thadishetty , Vignesh Kumar , Hemanth Venkateshwara

General aviation fault diagnosis and efficient maintenance are critical to flight safety; however, deploying deep learning models on resource-constrained edge devices poses dual challenges in computational capacity and interpretability.…

Artificial Intelligence · Computer Science 2026-04-03 Zhihuan Wei , Xinhang Chen , Danyang Han , Yang Hu , Jie Liu , Xuewen Miao , Guijiang Li

Computational pathology holds substantial promise for improving diagnosis and guiding treatment decisions. Recent pathology foundation models enable the extraction of rich patch-level representations from large-scale whole-slide images…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Xiangde Luo , Jinxi Xiang , Yuanfeng Ji , Ruijiang Li

Multimodal foundation models are transformative in sequential recommender systems, leveraging powerful representation learning capabilities. While Parameter-efficient Fine-tuning (PEFT) is commonly used to adapt foundation models for…

Information Retrieval · Computer Science 2024-07-23 Junchen Fu , Xuri Ge , Xin Xin , Alexandros Karatzoglou , Ioannis Arapakis , Jie Wang , Joemon M. Jose

Multiple Instance Learning (MIL) is the predominant framework for classifying gigapixel whole-slide images in computational pathology. MIL follows a sequence of 1) extracting patch features, 2) applying a linear layer to obtain…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Daniel Shao , Joel Runevic , Richard J. Chen , Drew F. K. Williamson , Ahrong Kim , Andrew H. Song , Faisal Mahmood