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The free energy of a system is central to many material models. Although free energy data is not generally found directly, its derivatives can be observed or calculated. In this work, we present an Integrable Deep Neural Network (IDNN) that…

Materials Science · Physics 2019-06-26 G. H. Teichert , A. R. Natarajan , A. Van der Ven , K. Garikipati

We present an approach that extends the theory of targeted free energy perturbation (TFEP) to calculate free energy differences and free energy surfaces at an accurate quantum mechanical level of theory from a cheaper reference potential.…

Computational Physics · Physics 2021-11-15 Andrea Rizzi , Paolo Carloni , Michele Parrinello

Enhanced sampling techniques have become an essential tool in computational chemistry and physics, where they are applied to sample activated processes that occur on a time scale that is inaccessible to conventional simulations. Despite…

Chemical Physics · Physics 2022-01-13 F. Giberti , G. A. Tribello , M. Ceriotti

A valuable step in the modeling of multiscale dynamical systems in fields such as computational chemistry, biology, materials science and more, is the representative sampling of the phase space over long timescales of interest; this task is…

Machine Learning · Computer Science 2023-12-29 Ellis R. Crabtree , Juan M. Bello-Rivas , Ioannis G. Kevrekidis

We describe and implement iMapD, a computer-assisted approach for accelerating the exploration of uncharted effective Free Energy Surfaces (FES), and more generally for the extraction of coarse-grained, macroscopic information from…

We develop a novel data-driven approach to the inverse problem of classical statistical mechanics: given experimental data on the collective motion of a classical many-body system, how does one characterise the free energy landscape of that…

Statistical Mechanics · Physics 2022-03-01 Peter Yatsyshin , Serafim Kalliadasis , Andrew B. Duncan

In this work, we further develop the Physics-informed Spectral Learning (PiSL) by Espath et al. \cite{Esp21} based on a discrete $L^2$ projection to solve the discrete Hodge--Helmholtz decomposition from sparse data. Within this…

Machine Learning · Computer Science 2023-02-23 Luis Espath , Pouria Behnoudfar , Raul Tempone

Free energies are fundamental quantities governing phase behavior and thermodynamic stability in polymer systems, yet their accurate computation often requires extensive simulations and post-processing techniques such as the Bennett…

Soft Condensed Matter · Physics 2026-03-19 Ian Chen , Alfredo Alexander-Katz

We show how to obtain improved active learning methods in the agnostic (adversarial noise) setting by combining marginal leverage score sampling with non-independent sampling strategies that promote spatial coverage. In particular, we…

Machine Learning · Computer Science 2024-05-07 Atsushi Shimizu , Xiaoou Cheng , Christopher Musco , Jonathan Weare

Functional-structural plant models (FSPM) replicate plants' responses to their environment and are useful for predicting behavior in a changing climate. However, they rely on detailed measurements of traits, which are difficult to collect…

This paper introduces an innovative end-to-end model-based deep learning approach for efficient electromagnetic analysis of high-dimensional frequency selective surfaces (FSS). Unlike traditional data-driven methods that require large…

Machine Learning · Computer Science 2024-10-23 Cheima Hammami , Lucas Polo-López , Luc Le Magoarou

Advances in manufacturing and characterization of complex molecular systems have created a need for new methods for design at molecular length scales. Emerging approaches are increasingly relying on the use of Artificial Intelligence (AI),…

Soft Condensed Matter · Physics 2022-08-17 Dan Mendels , Fabian Byléhn , Timothy W. Sirk , Juan J. de Pablo

Prompt learning as a parameter-efficient method that has been widely adopted to adapt Vision-Language Models (VLMs) to downstream tasks. While hard-prompt design requires domain expertise and iterative optimization, soft-prompt methods rely…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Zherui Zhang , Jiaxin Wu , Changwei Wang , Rongtao Xu , Longzhao Huang , Wenhao Xu , Wenbo Xu , Li Guo , Shibiao Xu

Calculating relative free energies is a topic of substantial interest and has many applications including solvation and binding free energies, which are used in computational drug discovery. However, there remain the challenges of accuracy,…

Chemical Physics · Physics 2016-09-28 Asaf Farhi , Bipin Singh

A new approach for efficiently exploring the configuration space and computing the free energy of large atomic and molecular systems is proposed, motivated by an analogy with reinforcement learning. There are two major components in this…

Chemical Physics · Physics 2018-04-18 Linfeng Zhang , Han Wang , Weinan E

We introduce a novel approach for depth estimation using images obtained from monocular structured light systems. In contrast to many existing methods that depend on image matching, our technique employs a density voxel grid to represent…

Computer Vision and Pattern Recognition · Computer Science 2025-06-26 Zhuohang Yu , Kai Wang , Kun Huang , Juyong Zhang

Machine learning (ML) potentials are a powerful tool in molecular modeling, enabling ab initio accuracy for comparably small computational costs. Nevertheless, all-atom simulations employing best-performing graph neural network…

Chemical Physics · Physics 2025-05-13 Sebastien Röcken , Anton F. Burnet , Julija Zavadlav

Magnetic particle imaging (MPI) is a tracer-based imaging modality that detects superparamagnetic iron oxide nanoparticles in vivo, with applications in cancer cell tracking, lymph node mapping, and cell therapy monitoring. We introduce a…

Accurate forest height estimation is crucial for climate change monitoring and carbon cycle assessment. Synthetic Aperture Radar (SAR), particularly in multi-channel configurations, has provided support for a long time in 3D forest…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Francesca Razzano , Wenyu Yang , Sergio Vitale , Giampaolo Ferraioli , Silvia Liberata Ullo , Gilda Schirinzi

Computing accurate reaction rates is a central challenge in computational chemistry and biology because of the high cost of free energy estimation with unbiased molecular dynamics. In this work, a data-driven machine learning algorithm is…

Computational Physics · Physics 2020-12-08 Lixin Sun , Jonathan Vandermause , Simon Batzner , Yu Xie , David Clark , Wei Chen , Boris Kozinsky