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Although neural networks are powerful function approximators, the underlying modelling assumptions ultimately define the likelihood and thus the hypothesis class they are parameterizing. In classification, these assumptions are minimal as…

Machine Learning · Computer Science 2021-11-24 Maria R. Cervera , Rafael Dätwyler , Francesco D'Angelo , Hamza Keurti , Benjamin F. Grewe , Christian Henning

Reliable uncertainty quantification is crucial for trustworthy decision-making and the deployment of AI models in medical imaging. While prior work has explored the ability of neural networks to quantify predictive, epistemic, and aleatoric…

Machine Learning · Statistics 2025-08-07 Simon Baur , Wojciech Samek , Jackie Ma

Quantitative magnetic resonance imaging (qMRI) is concerned with estimating (in physical units) values of magnetic and tissue parameters e.g., relaxation times $T_1$, $T_2$, or proton density $\rho$. Recently in [Ma et al., Nature, 2013],…

Optimization and Control · Mathematics 2019-03-29 Guozhi Dong , Michael Hintermüller , Kostas Papafitsoros

Quantitative MRI (qMRI) aims to map tissue properties non-invasively via models that relate these unknown quantities to measured MRI signals. Estimating these unknowns, which has traditionally required model fitting - an often iterative…

Medical Physics · Physics 2023-11-06 Michele Guerreri , Sean Epstein , Hojjat Azadbakht , Hui Zhang

Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging modality for measuring tissue metabolite levels in-vivo. An accurate estimation of spectral parameters allows for better assessment of spectral quality and metabolite…

Computer Vision and Pattern Recognition · Computer Science 2018-05-28 Dhritiman Das , Eduardo Coello , Rolf F Schulte , Bjoern H Menze

Decisions based partly or solely on predictions from probabilistic models may be sensitive to model misspecification. Statisticians are taught from an early stage that "all models are wrong", but little formal guidance exists on how to…

Methodology · Statistics 2015-03-09 James Watson , Chris Holmes

Strong consistency and asymptotic normality of the Quasi-Maximum Likelihood Estimator (QMLE) are given for a general class of multidimensional causal processes. For particular cases already studied in the literature (for instance univariate…

Statistics Theory · Mathematics 2009-01-09 Jean-Marc Bardet , Olivier Wintenberger

Natural language processing (NLP) shows promise as a means to automate the labelling of hospital-scale neuroradiology magnetic resonance imaging (MRI) datasets for computer vision applications. To date, however, there has been no thorough…

In causal inference, sensitivity models assess how unmeasured confounders could alter causal analyses, but the sensitivity parameter -- which quantifies the degree of unmeasured confounding -- is often difficult to interpret. For this…

Methodology · Statistics 2025-09-04 Alec McClean , Zach Branson , Edward H. Kennedy

Quantitative susceptibility mapping (QSM) utilizes MRI signal phase to infer estimates of local tissue magnetism (magnetic susceptibility), which has been shown useful to provide novel image contrast and as biomarkers of abnormal tissue.…

Medical Physics · Physics 2019-04-16 Juan Liu , Kevin M. Koch

The rapid progress in quantum computing (QC) and machine learning (ML) has attracted growing attention, prompting extensive research into quantum machine learning (QML) algorithms to solve diverse and complex problems. Designing…

Quantum Physics · Physics 2025-01-13 Samuel Yen-Chi Chen , Huan-Hsin Tseng , Hsin-Yi Lin , Shinjae Yoo

Signal amplitude estimation and detection from unlabeled quantized binary samples are studied, assuming that the order of the time indexes is completely unknown. First, maximum likelihood (ML) estimators are utilized to estimate both the…

Information Theory · Computer Science 2018-08-15 Guanyu Wang , Jiang Zhu , Rick S. Blum , Peter Willett , Stefano Marano , Vincenzo Matta , Paolo Braca

Obtaining channel covariance knowledge is of great importance in various Multiple-Input Multiple-Output MIMO communication applications, including channel estimation and covariance-based user grouping. In a massive MIMO system, covariance…

Information Theory · Computer Science 2019-11-01 Mahdi Barzegar Khalilsarai , Tianyu Yang , Saeid Haghighatshoar , Giuseppe Caire

We present USLR, a computational framework for longitudinal registration of brain MRI scans to estimate nonlinear image trajectories that are smooth across time, unbiased to any timepoint, and robust to imaging artefacts. It operates on the…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Adrià Casamitjana , Roser Sala-Llonch , Karim Lekadir , Juan Eugenio Iglesias

The problem of estimating an unknown deterministic parameter vector from sign measurements with a perturbed sensing matrix is studied in this paper. We analyze the best achievable mean square error (MSE) performance by exploring the…

Information Theory · Computer Science 2015-06-18 Jiang Zhu , Xiaohan Wang , Yuantao Gu

Survival models incorporating random effects to account for unmeasured heterogeneity are being increasingly used in biostatistical and applied research. Specifically, unmeasured covariates whose lack of inclusion in the model would lead to…

Methodology · Statistics 2020-05-06 Alessandro Gasparini , Mark S. Clements , Keith R. Abrams , Michael J. Crowther

We consider high-dimensional inference when the assumed linear model is misspecified. We describe some correct interpretations and corresponding sufficient assumptions for valid asymptotic inference of the model parameters, which still have…

Methodology · Statistics 2015-08-20 Peter Bühlmann , Sara van de Geer

There remains an open question about the usefulness and the interpretation of Machine learning (MLE) approaches for discrimination of spatial patterns of brain images between samples or activation states. In the last few decades, these…

Machine Learning · Statistics 2022-09-22 JM Gorriz , R. Martin-Clemente , C. G. Puntonet , A. Ortiz , J. Ramirez , J. Suckling

We consider estimation under model misspecification where there is a model mismatch between the underlying system, which generates the data, and the model used during estimation. We propose a model misspecification framework which enables a…

Signal Processing · Electrical Eng. & Systems 2023-02-22 Martin Hellkvist , Ayça Özçelikkale , Anders Ahlén

The constrained Cramer-Rao bound (CCRB) is a lower bound on the mean-squared-error (MSE) of estimators that satisfy some unbiasedness conditions. Although the CCRB unbiasedness conditions are satisfied asymptotically by the constrained…

Information Theory · Computer Science 2019-02-20 Eyal Nitzan , Tirza Routtenberg , Joseph Tabrikian