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Background: Quantitative susceptibility mapping (QSM) of the brain is an advanced MRI technique for assessing tissue characteristics based on magnetic susceptibility, which varies with the composition of the tissue, such as iron, calcium,…

Arterial spin labeling perfusion MRI is a noninvasive technique for measuring quantitative cerebral blood flow (CBF), but the measurement is subject to a low signal-to-noise-ratio(SNR). Various post-processing methods have been proposed to…

Computer Vision and Pattern Recognition · Computer Science 2018-01-31 Danfeng Xie , Li Bai , Ze Wang

The linear regression model with a random variable (RV) measurement matrix, where the mean of the random measurement matrix has full column rank, has been extensively studied. In particular, the quasiconvexity of the maximum likelihood…

Signal Processing · Electrical Eng. & Systems 2025-07-16 Ruohai Guo , Jiang Zhu , Xing Jiang , Fengzhong Qu

Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is a powerful imaging technology that can measure cerebral blood flow (CBF) quantitatively. However, since only a small portion of blood is labeled compared to the whole tissue…

Image and Video Processing · Electrical Eng. & Systems 2020-09-15 Jianan Cui , Kuang Gong , Paul Han , Huafeng Liu , Quanzheng Li

In fitting a mixture of linear regression models, normal assumption is traditionally used to model the error and then regression parameters are estimated by the maximum likelihood estimators (MLE). This procedure is not valid if the normal…

Methodology · Statistics 2018-11-06 Yanyuan Ma , Shaoli Wang , Lin Xu , Weixin Yao

A central question in machine learning is how reliable the predictions of a trained model are. Reliability includes the identification of instances for which a model is likely not to be trusted based on an analysis of the learning system…

Quantum Physics · Physics 2026-01-21 Marie Kempkes , Jakob Spiegelberg , Evert van Nieuwenburg , Vedran Dunjko

Model misspecification is ubiquitous in data analysis because the data-generating process is often complex and mathematically intractable. Therefore, assessing estimation uncertainty and conducting statistical inference under a possibly…

Methodology · Statistics 2023-12-19 Rong Li , Yichen Qin , Yang Li

Pseudo-measurements are the dominant source of uncertainty in distribution system state estimation (DSSE), yet their distributional assumptions are treated as fixed inputs by existing uncertainty quantification methods. This paper…

Systems and Control · Electrical Eng. & Systems 2026-05-14 Betül Mamudi , Jochen Stiasny , Jochen Cremer

We propose a framework for estimation and inference when the model may be misspecified. We rely on a local asymptotic approach where the degree of misspecification is indexed by the sample size. We construct estimators whose mean squared…

Econometrics · Economics 2021-10-11 Stéphane Bonhomme , Martin Weidner

The goal of this paper is to characterize the best achievable performance for the problem of estimating an unknown parameter having a sparse representation. Specifically, we consider the setting in which a sparsely representable…

Statistics Theory · Mathematics 2009-09-29 Zvika Ben-Haim , Yonina C. Eldar

In parametric estimation of covariance function of Gaussian processes, it is often the case that the true covariance function does not belong to the parametric set used for estimation. This situation is called the misspecified case. In this…

Statistics Theory · Mathematics 2015-11-13 François Bachoc

Multi-Delay single-shot arterial spin labeling (ASL) imaging provides accurate cerebral blood flow (CBF) and, in addition, arterial transit time (ATT) maps but the inherent low SNR can be challenging. Especially standard fitting using…

State estimators often provide self-assessed uncertainty metrics, such as covariance matrices, whose credibility is critical for downstream tasks. However, these self-assessments can be misleading due to underlying modeling violations like…

Signal Processing · Electrical Eng. & Systems 2026-04-02 Penggao Yan , Xingqun Zhan , Rui Sun , Li-Ta Hsu

We study behavior of the restricted maximum likelihood (REML) estimator under a misspecified linear mixed model (LMM) that has received much attention in recent gnome-wide association studies. The asymptotic analysis establishes consistency…

Statistics Theory · Mathematics 2014-04-10 Jiming Jiang , Cong Li , Debashis Paul , Can Yang , Hongyu Zhao

Quantitative magnetic resonance imaging (qMRI) is increasingly investigated for use in a variety of clinical tasks from diagnosis, through staging, to treatment monitoring. However, experiment design in qMRI, the identification of the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-23 Tianshu Zheng , Zican Wang , Timothy Bray , Daniel C. Alexander , Dan Wu , Hui Zhang

Inferring information from a set of acquired data is the main objective of any signal processing (SP) method. In particular, the common problem of estimating the value of a vector of parameters from a set of noisy measurements is at the…

Signal Processing · Electrical Eng. & Systems 2017-09-26 S. Fortunati , F. Gini , M. S. Greco , C. D. Richmond

We undertake a detailed study of the performance of maximum likelihood (ML) estimators of the density matrix of finite-dimensional quantum systems, in order to interrogate generic properties of frequentist quantum state estimation. Existing…

Quantum Physics · Physics 2011-11-16 Raj Chakrabarti , Anisha Ghosh

We study the asymptotic theory of misspecified models for diffusion processes with noisy nonsynchronous observations. Unlike with correctly specified models, the original maximum-likelihood-type estimator has an asymptotic bias under the…

Statistics Theory · Mathematics 2019-12-30 Teppei Ogihara

In the present paper we investigate the predictive risk of possibly misspecified quantile regression functions. The in-sample risk is well-known to be an overly optimistic estimate of the predictive risk and we provide two relatively simple…

Statistics Theory · Mathematics 2018-11-05 Alexander Giessing , Xuming He

The widely used quantum Cramer-Rao bound (QCRB) sets a lower bound for the mean square error of unbiased estimators in quantum parameter estimation, however, in general QCRB is only tight in the asymptotical limit. With a limited number of…

Quantum Physics · Physics 2016-09-07 Jing Liu , Haidong Yuan