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Understanding how 5' untranslated regions (5'UTRs) regulate mRNA translation is critical for controlling protein expression and designing effective therapeutic mRNAs. While recent deep learning models have shown promise in predicting…

Quantitative Methods · Quantitative Biology 2026-02-27 Yuxi Lin , Yaxue Fang , Zehong Zhang , Zhouwu Liu , Siyun Zhong , Zhongfang Wang , Fulong Yu

Sentiment analysis (SA) systems, though widely applied in many domains, have been demonstrated to produce biased results. Some research works have been done in automatically generating test cases to reveal unfairness in SA systems, but the…

Software Engineering · Computer Science 2022-01-06 Zhou Yang , Muhammad Hilmi Asyrofi , David Lo

Saliency maps are a popular approach to creating post-hoc explanations of image classifier outputs. These methods produce estimates of the relevance of each pixel to the classification output score, which can be displayed as a saliency map…

Machine Learning · Computer Science 2019-12-04 Richard Tomsett , Dan Harborne , Supriyo Chakraborty , Prudhvi Gurram , Alun Preece

Incorporating the Forward Forward algorithm into neural network training represents a transformative shift from traditional methods, introducing a dual forward mechanism that streamlines the learning process by bypassing the complexities of…

Machine Learning · Computer Science 2024-09-25 Mitra Bakhshi

Large language models can change answers under harmless edits that matter in practice: RAG outputs flip when passages are reordered, fine-tuning erodes invariances learned at pretraining, debate or chain-of-thought prompts take…

Machine Learning · Computer Science 2025-10-13 Edward Y. Chang , Ethan Y. Chang

Saliency maps are widely used in the computer vision community for interpreting neural network classifiers. However, due to the randomness of training samples and optimization algorithms, the resulting saliency maps suffer from a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Shizhan Gong , Jingwei Zhang , Qi Dou , Farzan Farnia

Pre-validation is a way to build prediction model with two datasets of significantly different feature dimensions. Previous work showed that the asymptotic distribution of the resulting test statistic for the pre-validated predictor…

Methodology · Statistics 2025-05-23 Jing Shang , Sourav Chatterjee , Trevor Hastie , Robert Tibshirani

This research addresses the challenge of conducting interpretable causal inference between a binary treatment and its resulting outcome when not all confounders are known. Confounders are factors that have an influence on both the treatment…

Machine Learning · Computer Science 2023-10-24 Sohaib Kiani , Jared Barton , Jon Sushinsky , Lynda Heimbach , Bo Luo

Decision processes of computer vision models - especially deep neural networks - are opaque in nature, meaning that these decisions cannot be understood by humans. Thus, over the last years, many methods to provide human-understandable…

Computer Vision and Pattern Recognition · Computer Science 2024-06-10 Benjamin Fresz , Lena Lörcher , Marco Huber

Deep neural networks are increasingly employed in high-stakes medical applications, despite their tendency for shortcut learning in the presence of spurious correlations, which can have potentially fatal consequences in practice. Whereas a…

Artificial Intelligence · Computer Science 2025-07-30 Frederik Pahde , Thomas Wiegand , Sebastian Lapuschkin , Wojciech Samek

Saliency map generation techniques are at the forefront of explainable AI literature for a broad range of machine learning applications. Our goal is to question the limits of these approaches on more complex tasks. In this paper we apply…

Machine Learning · Computer Science 2019-07-15 David Tuckey , Krysia Broda , Alessandra Russo

Recent efforts to improve the interpretability of deep neural networks use saliency to characterize the importance of input features to predictions made by models. Work on interpretability using saliency-based methods on Recurrent Neural…

Machine Learning · Computer Science 2019-10-29 Aya Abdelsalam Ismail , Mohamed Gunady , Luiz Pessoa , Héctor Corrada Bravo , Soheil Feizi

Variational inference provides approximations to the computationally intractable posterior distribution in Bayesian networks. A prominent medical application of noisy-or Bayesian network is to infer potential diseases given observed…

Machine Learning · Computer Science 2016-05-23 Yusheng Xie , Nan Du , Wei Fan , Jing Zhai , Weicheng Zhu

We present a novel method for reliably explaining the predictions of neural networks. We consider an explanation reliable if it identifies input features relevant to the model output by considering the input and the neighboring data points.…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Dohun Lim , Hyeonseok Lee , Sungchan Kim

Various saliency map methods have been proposed to interpret and explain predictions of deep learning models. Saliency maps allow us to interpret which parts of the input signals have a strong influence on the prediction results. However,…

Machine Learning · Statistics 2023-01-09 Daiki Miwa , Vo Nguyen Le Duy , Ichiro Takeuchi

Saliency computation models aim to imitate the attention mechanism in the human visual system. The application of deep neural networks for saliency prediction has led to a drastic improvement over the last few years. However, deep models…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Saman Zabihi , Hamed Rezazadegan Tavakoli , Ali Borji

Interpreting RNA-sequencing data requires identifying coordinated gene expression patterns that correspond to biological pathways. Standard factor models provide useful dimension reduction but typically ignore existing pathway knowledge or…

Methodology · Statistics 2026-03-25 Lorenzo Mauri , Federica Stolf , Amy H. Herring , Cameron Miller , David B. Dunson

Visual saliency detection tries to mimic human vision psychology which concentrates on sparse, important areas in natural image. Saliency prediction research has been traditionally based on low level features such as contrast, edge, etc.…

Computer Vision and Pattern Recognition · Computer Science 2016-05-05 Avisek Lahiri , Sourya Roy , Anirban Santara , Pabitra Mitra , Prabir Kumar Biswas

Transient stability assessment is an integral part of dynamic security assessment of power systems. Traditional methods of transient stability assessment, such as time domain simulation approach and direct methods, are appropriate for…

Systems and Control · Electrical Eng. & Systems 2021-11-23 Umair Shahzad

Prior sensitivity examination plays an important role in applied Bayesian analyses. This is especially true for Bayesian hierarchical models, where interpretability of the parameters within deeper layers in the hierarchy becomes…

Methodology · Statistics 2013-12-18 Malgorzata Roos , Thiago G. Martins , Leonhard Held , Havard Rue