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The electrocardiogram (ECG) remains a fundamental tool in cardiac diagnostics, yet its interpretation traditionally reliant on the expertise of cardiologists. The emergence of deep learning has heralded a revolutionary era in medical data…

Signal Processing · Electrical Eng. & Systems 2024-09-13 Cheng Ding , Tianliang Yao , Chenwei Wu , Jianyuan Ni

We propose DeepMiner, a framework to discover interpretable representations in deep neural networks and to build explanations for medical predictions. By probing convolutional neural networks (CNNs) trained to classify cancer in mammograms,…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Jimmy Wu , Bolei Zhou , Diondra Peck , Scott Hsieh , Vandana Dialani , Lester Mackey , Genevieve Patterson

While Multimodal Large Language Models (MLLMs) show promising performance in automated electrocardiogram interpretation, it remains unclear whether they genuinely perform actual step-by-step reasoning or just rely on superficial visual…

Machine Learning · Computer Science 2026-03-17 Jungwoo Oh , Hyunseung Chung , Junhee Lee , Min-Gyu Kim , Hangyul Yoon , Ki Seong Lee , Youngchae Lee , Muhan Yeo , Edward Choi

Heart disease is the number one killer, and ECGs can assist in the early diagnosis and prevention of deadly outcomes. Accurate ECG interpretation is critical in detecting heart diseases; however, they are often misinterpreted due to a lack…

Machine Learning · Computer Science 2021-10-29 Dharma KC , Chicheng Zhang , Chris Gniady , Parth Sandeep Agarwal , Sushil Sharma

Model interpretability is a requirement in many applications in which crucial decisions are made by users relying on a model's outputs. The recent movement for "algorithmic fairness" also stipulates explainability, and therefore…

Machine Learning · Computer Science 2018-08-21 Xuan Liu , Xiaoguang Wang , Stan Matwin

Electrocardiogram (ECG) can be reliably used as a measure to monitor the functionality of the cardiovascular system. Recently, there has been a great attention towards accurate categorization of heartbeats. While there are many…

Computers and Society · Computer Science 2018-11-06 Mohammad Kachuee , Shayan Fazeli , Majid Sarrafzadeh

Deep learning models have achieved strong performance in medical image analysis, but their internal decision processes remain difficult to interpret. Concept Bottleneck Models (CBMs) partially address this limitation by structuring…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Getamesay Dagnaw , Xuefei Yin , Muhammad Hassan Maqsood , Yanming Zhu , Alan Wee-Chung Liew

Background: Conventional electrocardiogram (ECG) analysis faces a persistent dichotomy: expert-driven features ensure interpretability but lack sensitivity to latent patterns, while deep learning offers high accuracy but functions as a…

Quantitative Methods · Quantitative Biology 2026-01-23 Deyun Zhang , Jun Li , Shijia Geng , Yue Wang , Shijie Chen , Sumei Fan , Qinghao Zha , Shenda Hong

This manuscript proposes a novel methodology for developing an interpretable prediction model for irregular Electrocardiogram (ECG) classification, using features extracted by a 1-D Deconvolutional Neural Network (1-D DNN). Given the…

Applications · Statistics 2024-10-17 Giacomo Lancia , Cristian Spitoni

Deep learning models have achieved remarkable accuracy in chest X-ray diagnosis, yet their widespread clinical adoption remains limited by the black-box nature of their predictions. Clinicians require transparent, verifiable explanations to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Yiming Tang , Wenjia Zhong , Rushi Shah , Dianbo Liu

Electrocardiography (ECG) offers critical cardiovascular insights, such as identifying arrhythmias and myocardial ischemia, but enabling automated systems to answer complex clinical questions directly from ECG signals (ECG-QA) remains a…

Signal Processing · Electrical Eng. & Systems 2025-05-13 Hung Manh Pham , Jialu Tang , Aaqib Saeed , Dong Ma

The electrocardiogram (ECG) is an essential and effective tool for diagnosing heart diseases. However, its effectiveness can be compromised by noise or unavailability of one or more leads of the standard 12-lead recordings, resulting in…

Machine Learning · Computer Science 2025-10-07 Huynh Dang Nguyen , Trong-Thang Pham , Ngan Le , Van Nguyen

Timely access to laboratory values is critical for clinical decision-making, yet current approaches rely on invasive venous sampling and are intrinsically delayed. Electrocardiography (ECG), as a non-invasive and widely available signal,…

Machine Learning · Computer Science 2025-10-28 Yujie Xiao , Gongzhen Tang , Wenhui Liu , Jun Li , Guangkun Nie , Zhuoran Kan , Deyun Zhang , Qinghao Zhao , Shenda Hong

Diagnosis prediction is a critical task in healthcare, where timely and accurate identification of medical conditions can significantly impact patient outcomes. Traditional machine learning and deep learning models have achieved notable…

Machine Learning · Computer Science 2025-01-09 Qiuhao Lu , Rui Li , Elham Sagheb , Andrew Wen , Jinlian Wang , Liwei Wang , Jungwei W. Fan , Hongfang Liu

As deep learning has achieved state-of-the-art performance for many tasks of EEG-based BCI, many efforts have been made in recent years trying to understand what have been learned by the models. This is commonly done by generating a heatmap…

Neural and Evolutionary Computing · Computer Science 2023-08-21 Jian Cui , Liqiang Yuan , Zhaoxiang Wang , Ruilin Li , Tianzi Jiang

Mobile electrocardiogram (ECG) recording technologies represent a promising tool to fight the ongoing epidemic of cardiovascular diseases, which are responsible for more deaths globally than any other cause. While the ability to monitor…

Signal Processing · Electrical Eng. & Systems 2018-10-10 Jennifer N. John , Conner Galloway , Alexander Valys

Electrocardiography (ECG) signal is a highly applied measurement for individual heart condition, and much effort have been endeavored towards automatic heart arrhythmia diagnosis based on machine learning. However, traditional machine…

Signal Processing · Electrical Eng. & Systems 2021-11-01 Ziyu Liu , Xiang Zhang

Electrocardiography (ECG) is an effective and non-invasive diagnostic tool that measures the electrical activity of the heart. Interpretation of ECG signals to detect various abnormalities is a challenging task that requires expertise.…

Ultrasound is a non-invasive imaging modality that can be conveniently used to classify suspicious breast nodules and potentially detect the onset of breast cancer. Recently, Convolutional Neural Networks (CNN) techniques have shown…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Hamza Rasaee , Hassan Rivaz

Deep neural networks have been well-known for their superb handling of various machine learning and artificial intelligence tasks. However, due to their over-parameterized black-box nature, it is often difficult to understand the prediction…

Machine Learning · Computer Science 2022-07-18 Xuhong Li , Haoyi Xiong , Xingjian Li , Xuanyu Wu , Xiao Zhang , Ji Liu , Jiang Bian , Dejing Dou