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This article focuses on parameter estimation of multi-levels nonlinear mixed effects models (MNLMEMs). These models are used to analyze data presenting multiple hierarchical levels of grouping (cluster data, clinical trials with several…

Methodology · Statistics 2008-12-18 Xavière Panhard , Adeline Samson

Modeling sparse data such as microbiome and transcriptomics (RNA-seq) data is very challenging due to the exceeded number of zeros and skewness of the distribution. Many probabilistic models have been used for modeling sparse data,…

Methodology · Statistics 2021-12-30 Hani Aldirawi , Jie Yang

We study empirical Bayes (EB) predictive density estimation in linear mixed models (LMMs) with large number of units, which induce a high dimensional random effects space. Focusing on Kullback Leibler (KL) risk minimization, we develop a…

Methodology · Statistics 2026-03-31 Abir Sarkar , Gourab Mukherjee , Keisuke Yano

Artificial intelligence(AI)-assisted method had received much attention in the risk field such as disease diagnosis. Different from the classification of disease types, it is a fine-grained task to classify the medical images as benign or…

Computer Vision and Pattern Recognition · Computer Science 2022-06-10 Shuang Ge , Kehong Yuan , Maokun Han , Desheng Sun , Huabin Zhang , Qiongyu Ye

In this paper we introduce the zero-adjusted Birnbaum-Saunders regression model. This new model generalizes at least seven Birnbaum-Saunders regression models. The idea of this modeling is mixing a degenerate distribution at zero with a…

Methodology · Statistics 2020-07-27 Vera Tomazella , Juvêncio S. Nobre , Gustavo H. A. Pereira , Manoel Santos-Neto

Mixture of Experts (MoE) are successful models for modeling heterogeneous data in many statistical learning problems including regression, clustering and classification. Generally fitted by maximum likelihood estimation via the well-known…

Machine Learning · Statistics 2018-10-30 Faicel Chamroukhi , Bao-Tuyen Huynh

In this work, we are interested in the stability and robustness of the parameter estimation in the Zero-Inflated Bernoulli (ZIBer) model, when the susceptible probability (SP) model is modeled by numerous different binary models: logit,…

Methodology · Statistics 2023-01-25 Essoham Ali , Kim-Hung Pho

Many data sets cannot be accurately described by standard probability distributions due to the excess number of zero values present. For example, zero-inflation is prevalent in microbiome data and single-cell RNA sequencing data, which…

Methodology · Statistics 2024-11-20 Max Beveridge , Zach Goldstein , Hee Cheol Chung

Estimation of Distribution Algorithms (EDAs) require flexible probability models that can be efficiently learned and sampled. Deep Boltzmann Machines (DBMs) are generative neural networks with these desired properties. We integrate a DBM…

Neural and Evolutionary Computing · Computer Science 2016-08-09 Malte Probst , Franz Rothlauf

Finite mixture models have been widely used to model and analyze data from a heterogeneous populations. Moreover, data of this kind can be missing or subject to some upper and/or lower detection limits because of the restriction of…

Nested error regression models are useful tools for analysis of grouped data, especially in the case of small area estimation. This paper suggests a nested error regression model using uncertain random effects in which the random effect in…

Methodology · Statistics 2017-02-28 Shonosuke Sugasawa , Tatsuya Kubokawa

A maximum likelihood methodology for the parameters of models with an intractable likelihood is introduced. We produce a likelihood-free version of the stochastic approximation expectation-maximization (SAEM) algorithm to maximize the…

Methodology · Statistics 2018-01-17 Umberto Picchini

Nonlinear mixed effects models have received a great deal of attention in the statistical literature in recent years because of their flexibility in handling longitudinal studies, including human immunodeficiency virus viral dynamics,…

Methodology · Statistics 2021-09-28 Fernanda L. Schumacher , Dipak K. Dey , Victor H. Lachos

In this paper, a long-term survival model under competing risks is considered. The unobserved number of competing risks is assumed to follow a negative binomial distribution that can capture both over- and under-dispersion. Considering the…

Methodology · Statistics 2021-07-22 Suvra Pal

In this paper, the use of the Generalized Beta Mixture (GBM) and Horseshoe distributions as priors in the Bayesian Compressive Sensing framework is proposed. The distributions are considered in a two-layer hierarchical model, making the…

Information Theory · Computer Science 2014-11-11 Zahra Sabetsarvestani , Hamidreza Amindavar

Tweedie's compound Poisson model is a popular method to model insurance claims with probability mass at zero and nonnegative, highly right-skewed distribution. In particular, it is not uncommon to have extremely unbalanced data with…

Computation · Statistics 2019-11-18 He Zhou , Yi Yang , Wei Qian

We consider the analysis of count data in which the observed frequency of zero counts is unusually large, typically with respect to the Poisson distribution. We focus on two alternative modelling approaches: Over-Dispersion (OD) models, and…

Methodology · Statistics 2021-07-30 John Haslett , Andrew C. Parnell , John Hinde , Rafael A. Moral

This paper studies the high-dimensional mixed linear regression (MLR) where the output variable comes from one of the two linear regression models with an unknown mixing proportion and an unknown covariance structure of the random…

Methodology · Statistics 2020-11-10 Linjun Zhang , Rong Ma , T. Tony Cai , Hongzhe Li

Regression mixture models are widely studied in statistics, machine learning and data analysis. Fitting regression mixtures is challenging and is usually performed by maximum likelihood by using the expectation-maximization (EM) algorithm.…

Methodology · Statistics 2014-09-25 Faicel Chamroukhi

The performances of automatic speech recognition (ASR) systems are usually evaluated by the metric word error rate (WER) when the manually transcribed data are provided, which are, however, expensively available in the real scenario. In…

Computation and Language · Computer Science 2020-09-01 Kai Fan , Jiayi Wang , Bo Li , Shiliang Zhang , Boxing Chen , Niyu Ge , Zhijie Yan