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Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $\beta$-cell mass and alteration of $\beta$-cell function in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis.…

Biological Physics · Physics 2021-05-04 Maryam Saadati , Yousef Jamali

This paper reviews a wide selection of machine learning models built to predict both the presence of diabetes and the presence of undiagnosed diabetes using eight years of National Health and Nutrition Examination Survey (NHANES) data.…

Machine Learning · Computer Science 2021-05-21 Avraham Adler

Diabetic Retinopathy (DR) is a serious and common complication of diabetes, caused by prolonged high blood sugar levels that damage the small retinal blood vessels. If left untreated, DR can progress to retinal vein occlusion and stimulate…

Image and Video Processing · Electrical Eng. & Systems 2025-04-07 Mohammad Reza Yousefi , Ali Bakrani , Amin Dehghani

According to the American Diabetes Association(ADA), 30.3 million people in the United States have diabetes, but only 7.2 million may be undiagnosed and unaware of their condition. Type 2 diabetes is usually diagnosed for most patients…

Machine Learning · Computer Science 2019-10-22 Ramya Akula , Ni Nguyen , Ivan Garibay

Background: Type 2 diabetes mellitus (T2DM) is increasingly recognised as a systemic disease characterised by coordinated dysfunction across metabolic, renal, lipid, and inflammatory pathways. Existing clinical assessments often fail to…

Machine Learning · Computer Science 2026-05-26 Mini Han Wang , Liting Huang , Wei Hong , Boonthawan Wingwon

Background and objective: Diabetes is a chronic pathology which is affecting more and more people over the years. It gives rise to a large number of deaths each year. Furthermore, many people living with the disease do not realize the…

Diabetes mellitus affects over 537 million adults worldwide and remains a major challenge in preventive healthcare. Existing machine-learning studies primarily formulate diabetes prediction as a binary classification problem, while…

Machine Learning · Computer Science 2026-05-14 Vishal Pandey , Ruzina Haque Laskar , Rishav Tewari

Diabetes, resulting from inadequate insulin production or utilization, causes extensive harm to the body. Existing diagnostic methods are often invasive and come with drawbacks, such as cost constraints. Although there are machine learning…

Machine Learning · Computer Science 2024-09-24 Zeyu Zhang , Khandaker Asif Ahmed , Md Rakibul Hasan , Tom Gedeon , Md Zakir Hossain

Discoveries of new biomarkers for frequently occurring diseases are of special importance in today's medicine. While fully developed type II diabetes (T2D) can be detected easily, the early identification of high risk individuals is an area…

Genomics · Quantitative Biology 2015-05-05 Balázs Szalkai , Vince Grolmusz

Precise and timely forecasting of blood glucose levels is essential for effective diabetes management. While extensive research has been conducted on Type 1 diabetes mellitus, Type 2 diabetes mellitus (T2DM) presents unique challenges due…

Computational Engineering, Finance, and Science · Computer Science 2024-09-12 Yuyang Sun , Panagiotis Kosmas

Diabetes mellitus (DM) is a global health issue of significance that must be diagnosed as early as possible and managed well. This study presents a framework for diabetes prediction using Machine Learning (ML) models, complemented with…

Machine Learning · Computer Science 2025-02-13 Pir Bakhsh Khokhar , Viviana Pentangelo , Fabio Palomba , Carmine Gravino

High quality real world datasets are essential for advancing data driven approaches in type 1 diabetes (T1D) management, including personalized therapy design, digital twin systems, and glucose prediction models. However, progress in this…

Machine Learning · Computer Science 2025-06-19 Saman Khamesian , Asiful Arefeen , Bithika M. Thompson , Maria Adela Grando , Hassan Ghasemzadeh

Type 1 diabetes (T1D) is a highly metabolically heterogeneous disease that cannot be adequately characterized by conventional biomarkers such as glycated hemoglobin (HbA1c). This study proposes an explainable deep learning framework that…

Machine Learning · Computer Science 2026-01-09 Pir Bakhsh Khokhar , Carmine Gravino , Fabio Palomba , Sule Yildrim Yayilgan , Sarang Shaikh

Background: Many studies have been conducted on the genetic and epigenetic etiology of gestational diabetes mellitus (GDM) in the last two decades because of the diseases increasing prevalence and role in the global diabetes mellitus (DM)…

Genomics · Quantitative Biology 2021-01-20 Tajudeen Yahaya , Titilola Salisu , Yusuf Abdulrahman , Abdulrazak Umar

Identifying type 2 diabetes mellitus can be challenging, particularly for primary care physicians. Clinical decision support systems incorporating artificial intelligence (AI-CDSS) can assist medical professionals in diagnosing type 2…

Machine Learning · Computer Science 2026-02-13 Mujeeb Ur Rehman , Imran Rehan , Sohail Khalid

Cardiovascular disease and chronic kidney disease are major complications of diabetes, leading to high morbidity and mortality. Early detection of these conditions is critical, yet traditional diagnostic markers often lack sensitivity in…

Other Quantitative Biology · Quantitative Biology 2025-10-20 Syed Ibad Hasnain

Metabolic disorders, particularly type 2 diabetes mellitus (T2DM), represent a significant global health burden, disproportionately impacting genetically predisposed populations such as the Pima Indians (a Native American tribe from south…

Machine Learning · Computer Science 2025-09-24 Iram Wajahat , Amritpal Singh , Fazel Keshtkar , Syed Ahmad Chan Bukhari

In many nations, diabetes is becoming a significant health problem, and early identification and control are crucial. Using machine learning algorithms to predict diabetes has yielded encouraging results. Using the Pima Indians Diabetes…

Machine Learning · Computer Science 2025-06-13 Mowafaq Salem Alzboon , Mohammad Al-Batah , Muhyeeddin Alqaraleh , Ahmad Abuashour , Ahmad Fuad Bader

Motivated by the need to study the molecular mechanism underlying Type 1 Diabetes (T1D) with the gene expression data collected from both the patients and healthy controls at multiple time points, we propose an innovative method for jointly…

Methodology · Statistics 2018-12-10 Bochao Jia , Faming Liang , the TEDDY Study Group

Type 2 Diabetes is one of the most major and fatal diseases known to human beings, where thousands of people are subjected to the onset of Type 2 Diabetes every year. However, the diagnosis and prevention of Type 2 Diabetes are relatively…