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Reconstructing cardiac electrical activity from body surface electric potential measurements results in the severely ill-posed inverse problem in electrocardiography. Many different regularization approaches have been proposed to improve…

Numerical Analysis · Mathematics 2025-11-04 Manuel Haas , Thomas Grandits , Thomas Pinetz , Thomas Beiert , Simone Pezzuto , Alexander Effland

This paper proposes a data-driven model for solving the inverse problem of electrocardiography, the mathematical problem that forms the basis of electrocardiographic imaging (ECGI). We present a conditional diffusion framework that learns a…

Machine Learning · Computer Science 2026-01-27 Ramiro Valdes Jara , Adam Meyers

Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. Many approaches have been developed to better estimate the cardiac muscle deformation, and to obtain a practical model to be used in diagnostic…

Computational Engineering, Finance, and Science · Computer Science 2015-12-01 Ahmadreza Baghaie , Hamid Abrishami Moghaddam

Electrocardiographic imaging (ECGI) aims to non-invasively reconstruct activation maps of the heart from temporal body surface potentials. While most existing approaches rely on inverse and optimization techniques that may yield…

Methodology · Statistics 2025-09-25 Emma Lagracie , Luc de Montella

Cardiac arrhythmias are a major cause of morbidity and mortality increasing the risk of stroke, heart failure, and sudden cardiac death. Imageless electrocardiographic imaging (ECGI) provides a non invasive alternative to electrical mapping…

Electrocardiography (ECG) analysis is crucial for cardiac diagnosis, yet existing foundation models often fail to capture the periodicity and diverse features required for varied clinical tasks. We propose ECG-MoE, a hybrid architecture…

Artificial Intelligence · Computer Science 2026-03-06 Yuhao Xu , Xiaoda Wang , Yi Wu , Wei Jin , Xiao Hu , Carl Yang

In electrocardiography, the "classic" inverse problem is the reconstruction of electric potentials at a surface enclosing the heart from remote recordings at the body surface and an accurate description of the anatomy. The latter being…

Numerical Analysis · Mathematics 2021-06-29 Lia Gander , Rolf Krause , Michael Multerer , Simone Pezzuto

Solving inverse problems in cardiac electrophysiology consists in the recovery of physiological parameters from surface electrocardiogram (ECG) measurements, a task which is often computationally unfeasible due to the severe ill-posedness…

Numerical Analysis · Mathematics 2026-05-05 Edoardo Centofanti , Giovanni Ziarelli , Simone Scacchi , Luca Franco Pavarino

Electrocardiographic imaging aims to noninvasively reconstruct the electrical dynamic patterns on the heart surface from body-surface ECG measurements, aiding the mechanistic study of cardiac function. At the core of ECGI lies the inverse…

Signal Processing · Electrical Eng. & Systems 2026-04-10 Lingzhen Zhu , Kenneth Bilchick , Jianxin Xie

We present a framework for solving a broad class of ill-posed inverse problems governed by partial differential equations (PDEs), where the target coefficients of the forward operator are recovered through an iterative regularization scheme…

Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. For this reason, many approaches have been developed to best estimate the cardiac muscle deformation, and to obtain a practical model to use in…

Computational Engineering, Finance, and Science · Computer Science 2014-12-09 Ahmadreza Baghaie , Hamid Abrishami Moghaddam

Electrocardiograms (ECGs) are an established technique to screen for abnormal cardiac signals. Recent work has established that it is possible to detect arrhythmia directly from the ECG signal using deep learning algorithms. While a few…

Signal Processing · Electrical Eng. & Systems 2024-11-28 Hyewon Jeong , Suyeol Yun , Hammaad Adam

Personalized cardiac mechanics modeling is a powerful tool for understanding the biomechanics of cardiac function in health and disease and assisting in treatment planning. However, current models are limited to using medical images…

Medical Physics · Physics 2024-04-09 Lei Shi , Ian Chen , Hiroo Takayama , Vijay Vedula

Mathematical models of the human heart are increasingly playing a vital role in understanding the working mechanisms of the heart, both under healthy functioning and during disease. The aim is to aid medical practitioners diagnose and treat…

Numerical Analysis · Mathematics 2023-11-13 Sridhar Chellappa , Barış Cansız , Lihong Feng , Peter Benner , Michael Kaliske

Convolutional neural networks (CNN) have demonstrated their ability to segment 2D cardiac ultrasound images. However, despite recent successes according to which the intra-observer variability on end-diastole and end-systole images has been…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Nathan Painchaud , Nicolas Duchateau , Olivier Bernard , Pierre-Marc Jodoin

Electrocardiogram (ECG) analysis plays a vital role in the early detection, monitoring, and management of various cardiovascular conditions. While existing models have achieved notable success in ECG interpretation, they fail to leverage…

Machine Learning · Computer Science 2026-03-05 Yuhao Xu , Xiaoda Wang , Jiaying Lu , Sirui Ding , Defu Cao , Huaxiu Yao , Yan Liu , Xiao Hu , Carl Yang

This work addresses the inverse problem of electrocardiography from a new perspective, by combining electrical and mechanical measurements. Our strategy relies on the defini-tion of a model of the electromechanical contraction which is…

Numerical Analysis · Mathematics 2015-03-24 Cesare Corrado , Jean-Frédéric Gerbeau , Philippe Moireau

Quantitative characterization of tissue properties, known as elasticity imaging, can be cast as solving an ill-posed inverse problem. The finite element methods (FEMs) in magnetic resonance elastography (MRE) imaging are based on solving a…

Image and Video Processing · Electrical Eng. & Systems 2021-03-29 Narges Mohammadi , Marvin M. Doyley , Mujdat Cetin

In this paper we present a new discretization strategy for the boundary element formulation of the Electroencephalography (EEG) forward problem. Boundary integral formulations, classically solved with the Boundary Element Method (BEM), are…

Medical Physics · Physics 2016-03-22 Lyes Rahmouni , Simon Adrian , Kristof Cools , Francesco P. Andriulli

This paper introduces a novel numerical method for the inverse problem of electroencephalography(EEG). We pose the inverse EEG problem as an optimal control (OC) problem for Poisson's equation. The optimality conditions lead to a…

Numerical Analysis · Mathematics 2022-04-15 M. S. Malovichko , N. B. Yavich , A. M. Razorenova , N. A. Koshev
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