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Effective learning from electronic health records (EHR) data for prediction of clinical outcomes is often challenging because of features recorded at irregular timesteps and loss to follow-up as well as competing events such as death or…

Machine Learning · Computer Science 2022-08-11 Intae Moon , Stefan Groha , Alexander Gusev

We propose a statistical-stochastic surrogate modeling approach to predict the response of the mean and variance statistics under various initial conditions and external forcing perturbations. The proposed modeling framework extends the…

Data Analysis, Statistics and Probability · Physics 2023-04-07 Di Qi , John Harlim

We introduce a framework for analyzing ordinary differential equation (ODE) models of biological networks using statistical model checking (SMC). A key aspect of our work is the modeling of single-cell variability by assigning a probability…

Quantitative Methods · Quantitative Biology 2018-12-05 Bing Liu , Benjamin M. Gyori , P. S. Thiagarajan

Theoretical results regarding two-dimensional ordinary-differential equations (ODEs) with second-degree polynomial right-hand sides are summarized, with an emphasis on limit cycles, limit cycle bifurcations and multistability. The results…

Molecular Networks · Quantitative Biology 2017-05-30 Tomislav Plesa , Tomas Vejchodsky , Radek Erban

Neural Ordinary Differential Equations (ODE) are a promising approach to learn dynamic models from time-series data in science and engineering applications. This work aims at learning Neural ODE for stiff systems, which are usually raised…

Numerical Analysis · Mathematics 2021-10-04 Suyong Kim , Weiqi Ji , Sili Deng , Yingbo Ma , Christopher Rackauckas

Galactic systems are inherently multiphase, and understanding the roles and interactions of the various phases is key towards a more complete picture of galaxy formation and evolution. For instance, these interactions play a pivotal role in…

Astrophysics of Galaxies · Physics 2025-02-07 Brent Tan

Estimating causal effects for survival outcomes in the high-dimensional setting is an extremely important topic for many biomedical applications as well as areas of social sciences. We propose a new orthogonal score method for treatment…

Methodology · Statistics 2024-12-04 Jue Hou , Jelena Bradic , Ronghui Xu

In this paper, we study the stability of an Ordinary Differential Equation (ODE) usually referred to as Cyclic Feedback Loop, which typically models a biological network of molecules where each molecule regulates its successor in a cycle.…

Classical Analysis and ODEs · Mathematics 2023-04-26 Jules Guilberteau

We investigate different emergent dynamics namely oscillation quenching and revival of oscillation in a global network of identical oscillators coupled with diffusive (positive) delay coupling as it is perturbed by symmetry breaking…

Adaptation and Self-Organizing Systems · Physics 2019-02-20 Prosenjit Kundu , Lekha Sharma , Mauparna Nandan , Dibakar Ghosh , Chittaranjan Hens , Pinaki Pal

An important issue in survival analysis is the investigation and the modeling of hazard rates. Within a Bayesian nonparametric framework, a natural and popular approach is to model hazard rates as kernel mixtures with respect to a…

Statistics Theory · Mathematics 2009-08-14 Pierpaolo De Blasi , Giovanni Peccati , Igor Prünster

Statistical regression models whose mean functions are represented by ordinary differential equations (ODEs) can be used to describe phenomenons dynamical in nature, which are abundant in areas such as biology, climatology and genetics. The…

Methodology · Statistics 2017-05-15 Kyoungjae Lee , Jaeyong Lee , Sarat C. Dass

In this paper, a family of neural network-based survival models is presented. The models are specified based on piecewise definitions of the hazard function and the density function on a partitioning of the time; both constant and linear…

Machine Learning · Statistics 2024-03-28 Olov Holmer , Erik Frisk , Mattias Krysander

Solution of Ordinary Differential Equation (ODE) model of dynamical system may not agree with its observed values. Often this discrepancy can be attributed to unmodeled forcings in the evolution rule of the dynamical system. In this…

Computational Engineering, Finance, and Science · Computer Science 2021-08-13 Saurabh Dixit , Soumyendu Raha

The order/dimension of models derived on the basis of data is commonly restricted by the number of observations, or in the context of monitored systems, sensing nodes. This is particularly true for structural systems (e.g., civil or…

Machine Learning · Computer Science 2022-12-01 Zhilu Lai , Wei Liu , Xudong Jian , Kiran Bacsa , Limin Sun , Eleni Chatzi

We study, by means of a topological approach, the forced oscillations of second order functional retarded differential equations subject to periodic perturbations. We consider a delay-type functional dependence involving a gamma probability…

Classical Analysis and ODEs · Mathematics 2022-05-30 Alessandro Calamai , Maria Patrizia Pera , Marco Spadini

The existing Neural ODE formulation relies on an explicit knowledge of the termination time. We extend Neural ODEs to implicitly defined termination criteria modeled by neural event functions, which can be chained together and…

Machine Learning · Computer Science 2021-10-28 Ricky T. Q. Chen , Brandon Amos , Maximilian Nickel

This paper is concerned with the robustness of the sustained oscillations predicted by an epidemic ODE model defined on contact networks. The model incorporates the spread of awareness among individuals and, moreover, a small inflow of…

Populations and Evolution · Quantitative Biology 2020-11-11 David Juher , David Rojas , Joan Saldaña

We analyze Neural Ordinary Differential Equations (NODEs) from a control theoretical perspective to address some of the main properties and paradigms of Deep Learning (DL), in particular, data classification and universal approximation.…

Optimization and Control · Mathematics 2021-04-13 Domènec Ruiz-Balet , Enrique Zuazua

This article proposes a dynamical system modeling approach for the analysis of longitudinal data of self-regulated systems experiencing multiple excitations. The aim of such an approach is to focus on the evolution of a signal (e.g., heart…

We introduce a general, flexible, parametric survival modelling framework which encompasses key shapes of hazard function (constant, increasing, decreasing, up-then-down, down-then-up), various common survival distributions (log-logistic,…

Methodology · Statistics 2019-01-11 Kevin Burke , M. C. Jones , Angela Noufaily