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The rapid growth in published clinical trials makes it difficult to maintain up-to-date systematic reviews, which requires finding all relevant trials. This leads to policy and practice decisions based on out-of-date, incomplete, and biased…

Computation and Language · Computer Science 2021-09-07 Shifeng Liu , Yifang Sun , Bing Li , Wei Wang , Florence T. Bourgeois , Adam G. Dunn

Standard decoding strategies for text generation, including top-k, nucleus sampling, and contrastive search, select tokens based on likelihood, restricting selection to high-probability regions. Human language production operates…

Computation and Language · Computer Science 2026-03-20 Esteban Garces Arias , Nurzhan Sapargali , Christian Heumann , Matthias Aßenmacher

Social media is becoming an increasingly important source of information to complement traditional pharmacovigilance methods. In order to identify signals of potential adverse drug reactions, it is necessary to first identify medical…

Artificial Intelligence · Computer Science 2015-04-28 Alejandro Metke-Jimenez , Sarvnaz Karimi

Delirium is an acute decline or fluctuation in attention, awareness, or other cognitive function that can lead to serious adverse outcomes. Despite the severe outcomes, delirium is frequently unrecognized and uncoded in patients' electronic…

Clinical documentation can contain emotionally charged language with stigmatizing or privileging valences. We present a framework for detecting and classifying such language as stigmatizing, privileging, or neutral. We constructed a curated…

Background Concept extraction, a subdomain of natural language processing (NLP) with a focus on extracting concepts of interest, has been adopted to computationally extract clinical information from text for a wide range of applications…

We decompose physician disagreement in the HealthBench medical AI evaluation dataset to understand where variance resides and what observable features can explain it. Rubric identity accounts for 15.8% of met/not-met label variance but only…

Artificial Intelligence · Computer Science 2026-03-10 Satya Borgohain , Roy Mariathas

Clinicians increasingly rely on prediction models to guide treatment choices. Most prediction models, however, are developed using observational data that include some patients who have already received the treatment the prediction model is…

Communication of follow-up recommendations when abnormalities are identified on imaging studies is prone to error. In this paper, we present a natural language processing approach based on deep learning to automatically identify clinically…

Computation and Language · Computer Science 2019-05-16 Wilson Lau , Thomas H Payne , Ozlem Uzuner , Meliha Yetisgen

Clinical practice guidelines are designed to guide clinical practice and involve causal language. Sometimes guidelines make or require stronger causal claims than those in the references they rely on, a phenomenon we refer to as 'causal…

Applications · Statistics 2026-02-06 Keling Wang , Chang Wei , Jeremy A. Labrecque

The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific…

Computation and Language · Computer Science 2025-03-11 Luyi Jiang , Jiayuan Chen , Lu Lu , Xinwei Peng , Lihao Liu , Junjun He , Jie Xu

\textbf{Background:} Regulatory frameworks for AI in healthcare, including the EU AI Act and FDA guidance on AI/ML-based medical devices, require clinical decision support to demonstrate not only accuracy but auditability. Existing formal…

Artificial Intelligence · Computer Science 2026-04-24 Michael Bouzinier , Sergey Trifonov , Michael Chumack , Eugenia Lvova , Dmitry Etin

Introduction: Clinical text classification using natural language processing (NLP) models requires adequate training data to achieve optimal performance. For that, 200-500 documents are typically annotated. The number is constrained by time…

Computation and Language · Computer Science 2026-01-23 Jaya Chaturvedi , Saniya Deshpande , Chenkai Ma , Robert Cobb , Angus Roberts , Robert Stewart , Daniel Stahl , Diana Shamsutdinova

Medical concept extraction from electronic health records underpins many downstream applications, yet remains challenging because medically meaningful concepts are frequently implied rather than explicitly stated in medical narratives.…

Computation and Language · Computer Science 2026-05-21 Zhichao Yang , Gregory D. Lyng , Sanjit Singh Batra , Robert E. Tillman

Automatic extraction of clinical concepts is an essential step for turning the unstructured data within a clinical note into structured and actionable information. In this work, we propose a clinical concept extraction model for automatic…

Computation and Language · Computer Science 2018-11-28 Henghui Zhu , Ioannis Ch. Paschalidis , Amir Tahmasebi

Recent advances in large language models have led to renewed interest in natural language processing in healthcare using the free text of clinical notes. One distinguishing characteristic of clinical notes is their long time span over…

Computation and Language · Computer Science 2023-07-17 Hongyi Zheng , Yixin Zhu , Lavender Yao Jiang , Kyunghyun Cho , Eric Karl Oermann

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

Many batch RL health applications first discretize time into fixed intervals. However, this discretization both loses resolution and forces a policy computation at each (potentially fine) interval. In this work, we develop a novel framework…

Machine Learning · Computer Science 2021-01-12 Kristine Zhang , Yuanheng Wang , Jianzhun Du , Brian Chu , Leo Anthony Celi , Ryan Kindle , Finale Doshi-Velez

Accurate clinical diagnosis requires extensive domain knowledge and complex clinical reasoning capabilities. Although large language models (LLMs) hold great potential for clinical reasoning, their high computational and memory requirements…

Computers and Society · Computer Science 2026-05-12 Xinchun Su , Chunxu Luo , Lipeng Ma , Yixuan Li , Weidong Yang

This paper proposes a new natural language processing (NLP) application for identifying medical jargon terms potentially difficult for patients to comprehend from electronic health record (EHR) notes. We first present a novel and publicly…

Computation and Language · Computer Science 2022-10-13 Sunjae Kwon , Zonghai Yao , Harmon S. Jordan , David A. Levy , Brian Corner , Hong Yu