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The Precision Medicine Initiative states that treatments for a patient should take into account not only the patient's disease, but his/her specific genetic variation as well. The vast biomedical literature holds the potential for…

Information Retrieval · Computer Science 2019-04-22 Jiaming Qu , Yue Wang

Large language models (LLMs), particularly those with reasoning capabilities, have rapidly advanced in recent years, demonstrating significant potential across a wide range of applications. However, their deployment in healthcare,…

Artificial Intelligence · Computer Science 2025-02-27 Guoxin Wang , Minyu Gao , Shuai Yang , Ya Zhang , Lizhi He , Liang Huang , Hanlin Xiao , Yexuan Zhang , Wanyue Li , Lu Chen , Jintao Fei , Xin Li

Current evaluation of large language models (LLMs) overwhelmingly prioritizes accuracy; however, in real-world and safety-critical applications, the ability to abstain when uncertain is equally vital for trustworthy deployment. We introduce…

Computation and Language · Computer Science 2026-01-23 Sravanthi Machcha , Sushrita Yerra , Sahil Gupta , Aishwarya Sahoo , Sharmin Sultana , Hong Yu , Zonghai Yao

Recent advances in vision-language models (VLMs) have achieved remarkable performance on standard medical benchmarks, yet their true clinical reasoning ability remains unclear. Existing datasets predominantly emphasize classification…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Miao Jing , Mengting Jia , Junling Lin , Zhongxia Shen , Huan Gao , Mingkun Xu , Shangyang Li

In this paper, we reflect on ways to improve the quality of bio-medical information retrieval by drawing implicit negative feedback from negated information in noisy natural language search queries. We begin by studying the extent to which…

Information Retrieval · Computer Science 2016-08-08 Lorenz Kuhn , Carsten Eickhoff

Objectives: Medical research faces substantial challenges from noisy labels attributed to factors like inter-expert variability and machine-extracted labels. Despite this, the adoption of label noise management remains limited, and label…

Machine Learning · Computer Science 2024-03-21 Yishu Wei , Yu Deng , Cong Sun , Mingquan Lin , Hongmei Jiang , Yifan Peng

Multi-label text classification (MLTC) tasks in the medical domain often face the long-tail label distribution problem. Prior works have explored hierarchical label structures to find relevant information for few-shot classes, but mostly…

Computation and Language · Computer Science 2024-06-21 Xueren Ge , Satpathy Abhishek , Ronald Dean Williams , John A. Stankovic , Homa Alemzadeh

This study investigates whether large language models (LLMs) exhibit cross-linguistic differences in mental health evaluations. Focusing on Chinese and English, we examine two widely used models, GPT-4o and Qwen3, to assess whether prompt…

Computation and Language · Computer Science 2026-03-10 Jiayi Xu , Xiyang Hu

The clinical utility of deep learning models for medical image segmentation is severely constrained by their inability to generalize to unseen domains. This failure is often rooted in the models learning spurious correlations between…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Tao Tang , Shijie Xu , Jionglong Su , Zhixiang Lu

Clinical guidelines, typically structured as decision trees, are central to evidence-based medical practice and critical for ensuring safe and accurate diagnostic decision-making. However, it remains unclear whether Large Language Models…

Computation and Language · Computer Science 2025-05-20 Xiaomin Li , Mingye Gao , Yuexing Hao , Taoran Li , Guangya Wan , Zihan Wang , Yijun Wang

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Multimodal language models (MLMs) show promise for clinical decision support and diagnostic reasoning, raising the prospect of end-to-end automated medical image interpretation. However, clinicians are highly selective in adopting AI tools;…

Artificial Intelligence · Computer Science 2025-08-06 Mahtab Bigverdi , Wisdom Ikezogwo , Kevin Zhang , Hyewon Jeong , Mingyu Lu , Sungjae Cho , Linda Shapiro , Ranjay Krishna

This study addresses the problem of hallucinated span detection in the outputs of large language models. It has received less attention than output-level hallucination detection despite its practical importance. Prior work has shown that…

Computation and Language · Computer Science 2025-09-16 Yuya Ogasa , Yuki Arase

Speech monologues recorded in naturalistic settings provide opportunities to characterize mental illness phenomenology and detect symptom exacerbation. Large language models (LLMs) offer new possibilities for automating this process, as…

LongRecall. The completeness of machine-generated text, ensuring that it captures all relevant information, is crucial in domains such as medicine and law and in tasks like list-based question answering (QA), where omissions can have…

Computation and Language · Computer Science 2025-08-22 MohamamdJavad Ardestani , Ehsan Kamalloo , Davood Rafiei

While deep learning techniques have shown promising results in many natural language processing (NLP) tasks, it has not been widely applied to the clinical domain. The lack of large datasets and the pervasive use of domain-specific language…

Computation and Language · Computer Science 2019-06-20 Jiin Nam , Seunghyun Yoon , Kyomin Jung

Reliable deployment of Vision-Language Models (VLMs) in radiology requires validation metrics that go beyond surface-level text similarity to ensure clinical fidelity and demographic fairness. This paper investigates a critical blind spot…

Computation and Language · Computer Science 2026-03-03 Aditya Parikh , Aasa Feragen , Sneha Das , Stella Frank

The MEDIQA-CORR 2024 shared task aims to assess the ability of Large Language Models (LLMs) to identify and correct medical errors in clinical notes. In this study, we evaluate the capability of general LLMs, specifically GPT-3.5 and GPT-4,…

Computation and Language · Computer Science 2024-05-29 Aryo Pradipta Gema , Chaeeun Lee , Pasquale Minervini , Luke Daines , T. Ian Simpson , Beatrice Alex

The pre-trained vision-language model, exemplified by CLIP, advances zero-shot semantic segmentation by aligning visual features with class embeddings through a transformer decoder to generate semantic masks. Despite its effectiveness,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Zicheng Zhang , Tong Zhang , Yi Zhu , Jianzhuang Liu , Xiaodan Liang , QiXiang Ye , Wei Ke

Clinical text classification requires choosing between specialized fine-tuned models (BERT variants) and general-purpose large language models (LLMs), yet neither dominates across all instances. We introduce Learning to Defer for clinical…

Computation and Language · Computer Science 2026-04-16 Rishik Kondadadi , John E. Ortega
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