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Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…

Signal Processing · Electrical Eng. & Systems 2024-04-02 Arezoo Borji , Taha-Hossein Hejazi , Abbas Seifi

With the increasing number of patients diagnosed with Alzheimer's Disease, prognosis models have the potential to aid in early disease detection. However, current approaches raise dependability concerns as they do not account for…

Neurons and Cognition · Quantitative Biology 2024-08-28 Wael Mobeirek , Shirley Mao

This paper aims to develop a new deep learning-inspired gaming approach for early detection of dementia. This research integrates a robust convolutional neural network (CNN)-based model for early dementia detection using health metrics data…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Paramita Kundu Maji , Soubhik Acharya , Priti Paul , Sanjay Chakraborty , Saikat Basu

We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…

Machine Learning · Computer Science 2021-01-13 Alexander Lavin

Recent studies on modelling the progression of Alzheimer's disease use a single modality for their predictions while ignoring the time dimension. However, the nature of patient data is heterogeneous and time dependent which requires models…

Computers and Society · Computer Science 2021-10-19 Sofia Lahrichi , Maryem Rhanoui , Mounia Mikram , Bouchra El Asri

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

Serious games and gamification (SGG) have shown to have positive effects on health outcomes of eHealth applications. However, research has shown that a shift towards a personalized approach is needed, considering the diversity of users.…

Human-Computer Interaction · Computer Science 2026-03-31 Stéphanie Carlier , Femke De Backere , Filip De Turck

It is of great significance to apply deep learning for the early diagnosis of Alzheimer's Disease (AD). In this work, a novel tensorizing GAN with high-order pooling is proposed to assess Mild Cognitive Impairment (MCI) and AD. By…

Machine Learning · Computer Science 2020-08-04 Wen Yu , Baiying Lei , Michael K. Ng , Albert C. Cheung , Yanyan Shen , Shuqiang Wang

Cognitive diagnosis has been developed for decades as an effective measurement tool to evaluate human cognitive status such as ability level and knowledge mastery. It has been applied to a wide range of fields including education, sport,…

Artificial Intelligence · Computer Science 2024-07-09 Fei Wang , Weibo Gao , Qi Liu , Jiatong Li , Guanhao Zhao , Zheng Zhang , Zhenya Huang , Mengxiao Zhu , Shijin Wang , Wei Tong , Enhong Chen

It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Mild cognitive impairment is the early stage of several neurodegenerative diseases, such as Alzheimer's. In this work, we address the use of lifelogging as a tool to obtain pictures from a patient's daily life from an egocentric point of…

Computer Vision and Pattern Recognition · Computer Science 2017-07-28 Gabriel Oliveira-Barra , Marc Bolaños , Estefania Talavera , Adrián Dueñas , Olga Gelonch , Maite Garolera

The timely identification of significant memory concern (SMC) is crucial for proactive cognitive health management, especially in an aging population. Detecting SMC early enables timely intervention and personalized care, potentially…

Machine Learning · Computer Science 2024-05-31 M. Sajid , Rahul Sharma , Iman Beheshti , M. Tanveer

Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments. As clinical trials in AD increasingly focus on…

Cognitive decline is highly heterogeneous across individuals, which complicates prognosis, trial design, and treatment planning. We present the Personalized Cognitive Decline Assessment Digital Twin (PCD-DT), a multimodal and…

Artificial Intelligence · Computer Science 2026-05-01 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

The present review presents multiple techniques in which ocular assessments may serve as a noninvasive approach for the early diagnoses of various cognitive and psychiatric disorders, such as Alzheimer's disease (AD), autism spectrum…

Neurons and Cognition · Quantitative Biology 2020-04-06 Xiaotao Li , Xuejing Chen , Fangfang Fan , Li Ning , Kangguang Lin , Zan Chen , Zhenyun Qin , Albert S. Yeung , Liping Wang , Xiaojian Li , Kwok-Fai So

The rapid global aging trend has led to an increase in dementia cases, including Alzheimer's disease, underscoring the urgent need for early and accurate diagnostic methods. Traditional diagnostic techniques, such as cognitive tests,…

Machine Learning · Computer Science 2024-09-06 Juan A. Berrios Moya

Early and reliable detection of cognitive decline is one of the most important challenges of current healthcare. In this project we developed an approach whereby a frequently played computer game can be used to assess a variety of cognitive…

Quantitative Methods · Quantitative Biology 2016-11-15 Stuart Hagler , Holly B. Jimison , Misha Pavel

Computational models of neurodegeneration aim to emulate the evolving pattern of pathology in the brain during neurodegenerative disease, such as Alzheimer's disease. Previous studies have made specific choices on the mechanisms of…

Quantitative Methods · Quantitative Biology 2023-08-11 Tiantian He , Elinor Thompson , Anna Schroder , Neil P. Oxtoby , Ahmed Abdulaal , Frederik Barkhof , Daniel C. Alexander

This paper introduces an innovative adaptive scoring framework for children with Neurodevelopmental Disorders (NDD) that is attributed to the integration of multiple metrics, such as spatial attention patterns, temporal engagement, and game…

Human-Computer Interaction · Computer Science 2025-09-11 Abdul Rehman , Ilona Heldal , Cristina Costescu , Carmen David , Jerry Chun-Wei Lin

This paper focuses on developing a framework for uncovering insights about NDD children's performance (e.g., raw gaze cluster analysis, duration analysis \& area of interest for sustained attention, stimuli expectancy, loss of…

Human-Computer Interaction · Computer Science 2025-02-04 Abdul Rehman , Ilona Heldal , Diana Stilwell , Jerry Chun-Wei Lin
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