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Dual-energy computed tomography (DECT) enables material-specific imaging through acquisitions at two different X-ray energy spectra. Material decomposition from DECT data is an ill-posed inverse problem that is highly sensitive to noise…

Large datasets often contain multiple distinct feature sets, or views, that offer complementary information that can be exploited by multi-view learning methods to improve results. We investigate anatomical multi-view data, where each brain…

Quantitative Methods · Quantitative Biology 2024-01-17 Yuxiang Wei , Yuqian Chen , Tengfei Xue , Leo Zekelman , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O' Donnell

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the…

Computational Physics · Physics 2018-03-20 Amit Singer

Cryo-electron microscopy (cryo-EM) extracts single-particle density projections of individual biomolecules. Although cryo-EM is widely used for 3D reconstruction, due to its single-particle nature, it has the potential to provide…

Automated and semi-automated techniques in biomedical electron microscopy (EM) enable the acquisition of large datasets at a high rate. Segmentation methods are therefore essential to analyze and interpret these large volumes of data, which…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Anusha Aswath , Ahmad Alsahaf , Ben N. G. Giepmans , George Azzopardi

How do the neural networks distinguish two images? It is of critical importance to understand the matching mechanism of deep models for developing reliable intelligent systems for many risky visual applications such as surveillance and…

Computer Vision and Pattern Recognition · Computer Science 2021-08-13 Wenliang Zhao , Yongming Rao , Ziyi Wang , Jiwen Lu , Jie Zhou

Vision-language models, such as CLIP, have achieved significant success in aligning visual and textual representations, becoming essential components of many multi-modal large language models (MLLMs) like LLaVA and OpenFlamingo. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Shizhan Gong , Yankai Jiang , Qi Dou , Farzan Farnia

One of the difficulties in 3D reconstruction of molecules from images in single particle Cryo-Electron Microscopy (Cryo-EM), in addition to high levels of noise and unknown image orientations, is heterogeneity in samples: in many cases, the…

Computer Vision and Pattern Recognition · Computer Science 2016-07-13 Roy R. Lederman , Amit Singer

In recent years, deep learning has attracted increasing attention in the field of Cardiac MRI (CMR) reconstruction due to its superior performance over traditional methods, particularly in handling higher acceleration factors, highlighting…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Donghang Lyu , Marius Staring , Hildo Lamb , Mariya Doneva

We introduce a framework for recovering an image from its rotationally and translationally invariant features based on autocorrelation analysis. This work is an instance of the multi-target detection statistical model, which is mainly used…

Image and Video Processing · Electrical Eng. & Systems 2022-03-03 Nicholas F. Marshall , Ti-Yen Lan , Tamir Bendory , Amit Singer

Electron microscopy (EM) imaging offers unparalleled resolution for analyzing neural tissues, crucial for uncovering the intricacies of synaptic connections and neural processes fundamental to understanding behavioral mechanisms. Recently,…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Ruohua Shi , Qiufan Pang , Lei Ma , Lingyu Duan , Tiejun Huang , Tingting Jiang

Recently deep learning has been witnessing widespread adoption in various medical image applications. However, training complex deep neural nets requires large-scale datasets labeled with ground truth, which are often unavailable in many…

Computer Vision and Pattern Recognition · Computer Science 2018-05-29 Wentao Zhu , Yeeleng S. Vang , Yufang Huang , Xiaohui Xie

Recent advances in scanning transmission electron and scanning probe microscopies have opened exciting opportunities in probing the materials structural parameters and various functional properties in real space with angstrom-level…

The central problem in cryo-electron microscopy (cryo-EM) is to recover the 3D structure from noisy 2D projection images which requires estimating the missing projection angles (poses). Recent methods attempted to solve the 3D…

Computer Vision and Pattern Recognition · Computer Science 2023-02-15 Lin Yao , Ruihan Xu , Zhifeng Gao , Guolin Ke , Yuhang Wang

Accurate segmentation of medical images is essential for diagnosis and treatment of diseases. These problems are solved by highly complex models, such as deep networks (DN), requiring a large amount of labeled data for training. Thereby,…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Dario Sitnik , Ivica Kopriva

Low-energy electron microscopy (LEEM) is a surface science method that works primarily in the UHV environment. It provides information complementary to the other established techniques: it extends the limited view of scanning probe…

Mesoscale and Nanoscale Physics · Physics 2025-07-16 Jan Čechal , Pavel Procházka

Clinical decision-making agents can benefit from reusing prior decision experience. However, many memory-augmented methods store experiences as independent records without explicit relational structure, which may introduce noisy retrieval,…

Artificial Intelligence · Computer Science 2026-03-24 Xiao Han , Yuzheng Fan , Sendong Zhao , Haochun Wang , Bing Qin

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

Simulating microstructure evolution (MicroEvo) is vital for materials design but demands high numerical accuracy, efficiency, and physical fidelity. Although recent studies on deep learning (DL) offer a promising alternative to traditional…

Materials Science · Physics 2025-11-19 Qinyi Zhang , Duanyu Feng , Ronghui Han , Yangshuai Wang , Hao Wang

Motivation: Cryo-Electron Tomography (cryo-ET) visualizes structure and spatial organization of macromolecules and their interactions with other subcellular components inside single cells in the close-to-native state at sub-molecular…

Quantitative Methods · Quantitative Biology 2020-07-31 Liangyong Yu , Ran Li , Xiangrui Zeng , Hongyi Wang , Jie Jin , Ge Yang , Rui Jiang , Min Xu