Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution". This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.
Cite
@article{arxiv.1803.06714,
title = {Mathematics for cryo-electron microscopy},
author = {Amit Singer},
journal= {arXiv preprint arXiv:1803.06714},
year = {2018}
}
Comments
Proceedings of the International Congress of Mathematicians 2018