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Randomized experiments or randomized controlled trials (RCTs) are gold standards for causal inference, yet cost and sample-size constraints limit power. We introduce CALM (Causal Analysis leveraging Language Models), a statistical framework…

Methodology · Statistics 2025-12-09 Xinrui Ruan , Xinwei Ma , Yingfei Wang , Waverly Wei , Jingshen Wang

Zero-shot cross-lingual knowledge transfer enables the multilingual pretrained language model (mPLM), finetuned on a task in one language, make predictions for this task in other languages. While being broadly studied for natural language…

Computation and Language · Computer Science 2024-04-23 Nadezhda Chirkova , Sheng Liang , Vassilina Nikoulina

Unlocking the next generation of biotechnology and therapeutic innovation demands overcoming the inherent complexity and resource-intensity of conventional protein engineering methods. Recent GenAI-powered computational techniques often…

Genomic language models (gLMs) have transformed computational biology, achieving state-of-the-art performance across genomic tasks. Yet a fundamental question threatens the foundation of this success: do these models learn the mechanistic…

Genomics · Quantitative Biology 2026-04-09 Bryan Cheng , Jasper Zhang

Multimodal Large Language Models (MLLMs) are set to transform how machines process and generate human-like responses by integrating diverse modalities such as text, images, and code. Yet, effectively harnessing their capabilities hinges on…

Artificial Intelligence · Computer Science 2025-04-15 Anwesha Mohanty , Venkatesh Balavadhani Parthasarathy , Arsalan Shahid

Large Language Models (LLM) exhibit zero-shot mathematical reasoning capacity as a behavior emergent with scale, commonly manifesting as chain-of-thoughts (CoT) reasoning. However, multiple empirical findings suggest that this prowess is…

Artificial Intelligence · Computer Science 2023-12-20 Subhabrata Dutta , Joykirat Singh , Ishan Pandey , Sunny Manchanda , Soumen Chakrabarti , Tanmoy Chakraborty

In large-scale industrial LLM systems, prompt templates often expand to thousands of tokens as teams iteratively incorporate sections such as task instructions, few-shot examples, and heuristic rules to enhance robustness and coverage. This…

Computation and Language · Computer Science 2025-10-09 Zhentao Xu , Fengyi Li , Albert Chen , Xiaofeng Wang

Large language models (LLMs) have seen substantial growth, necessitating efficient model pruning techniques. Existing post-training pruning methods primarily measure weight importance in converged dense models, often overlooking changes in…

Machine Learning · Computer Science 2025-12-11 Yupeng Su , Ziyi Guan , Xiaoqun Liu , Tianlai Jin , Dongkuan Wu , Zhengfei Chen , Graziano Chesi , Ngai Wong , Hao Yu

Prompting methods play a crucial role in enhancing the capabilities of pre-trained large language models (LLMs). We explore how contrastive prompting (CP) significantly improves the ability of large language models to perform complex…

Computation and Language · Computer Science 2026-03-06 Liang Yao

Recent work has investigated the capabilities of large language models (LLMs) as zero-shot models for generating individual-level characteristics (e.g., to serve as risk models or augment survey datasets). However, when should a user have…

Pre-trained Language Models (PLMs) have the potential to transform mental health support by providing accessible and culturally sensitive resources. However, despite this potential, their effectiveness in mental health care and specifically…

Computation and Language · Computer Science 2024-06-25 Hassan Alhuzali , Ashwag Alasmari

While scaling laws have been continuously validated in large language models (LLMs) with increasing model parameters, the inherent tension between the inference demands of LLMs and the limited resources of edge devices poses a critical…

Large language models (LLMs) demonstrate the capacity to reconstruct and trace learned content from their training data under specific elicitation conditions, yet this capability does not manifest in standard generation contexts. This…

Computation and Language · Computer Science 2026-03-20 Toshiyuki Shigemura

We propose a novel application of prompting Pre-trained Language Models (PLMs) to generate analogies and study how to design effective prompts for two task settings: generating a source concept analogous to a given target concept (aka…

Computation and Language · Computer Science 2022-10-12 Bhavya Bhavya , Jinjun Xiong , Chengxiang Zhai

Recent advancements in Large Language Models (LLMs) have shown that it is promising to utilize Process Reward Models (PRMs) as verifiers to enhance the performance of LLMs. However, current PRMs face three key challenges: (1) limited…

Computation and Language · Computer Science 2025-04-08 Jian Zhao , Runze Liu , Kaiyan Zhang , Zhimu Zhou , Junqi Gao , Dong Li , Jiafei Lyu , Zhouyi Qian , Biqing Qi , Xiu Li , Bowen Zhou

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

Machine Learning · Computer Science 2025-05-27 Hazem Alsamkary , Mohamed Elshaffei , Mohamed Elkerdawy , Ahmed Elnaggar

In recent years, Large Language Models (LLMs) have demonstrated exceptional proficiency across a broad spectrum of Natural Language Processing (NLP) tasks, including Machine Translation. However, previous methods predominantly relied on…

Deep learning algorithms are dependent on the availability of large-scale annotated clinical text datasets. The lack of such publicly available datasets is the biggest bottleneck for the development of clinical Natural Language…

Computation and Language · Computer Science 2022-03-11 Sonish Sivarajkumar , Yanshan Wang

Large language models (LLMs) have garnered significant attention, but the definition of "large" lacks clarity. This paper focuses on medium-sized language models (MLMs), defined as having at least six billion parameters but less than 100…

Computation and Language · Computer Science 2023-07-06 René Peinl , Johannes Wirth

Language modeling studies the probability distributions over strings of texts. It is one of the most fundamental tasks in natural language processing (NLP). It has been widely used in text generation, speech recognition, machine…

Computation and Language · Computer Science 2024-07-18 Chengwei Wei , Yun-Cheng Wang , Bin Wang , C. -C. Jay Kuo