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Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data. Here, we discuss recent work using…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , Johan Nakuci , Sarah Feldt Muldoon

As large language models (LLMs) continue to revolutionize AI research, there is a growing interest in building large-scale brain foundation models to advance neuroscience. While most existing brain foundation models are pre-trained on…

Neurons and Cognition · Quantitative Biology 2026-02-11 Xinxu Wei , Kanhao Zhao , Yong Jiao , Lifang He , Yu Zhang

Accurately monitoring cognitive load in real time is critical for Brain-Computer Interfaces (BCIs) that adapt to user engagement and support personalized learning. Electroencephalography (EEG) offers a non-invasive, cost-effective modality…

Human-Computer Interaction · Computer Science 2026-05-04 Deeksha M. Shama , Dimitra Emmanouilidou , Ivan J. Tashev

We introduce a probabilistic (Bayesian) framework and associated software toolbox for mapping population receptive fields (pRFs) based on fMRI data. This generic approach is intended to work with stimuli of any dimension and is demonstrated…

Neurons and Cognition · Quantitative Biology 2018-05-21 Peter Zeidman , Edward Harry Silson , Dietrich Samuel Schwarzkopf , Chris Ian Baker , Will Penny

The distributed nature of the neural substrate, and the difficulty of establishing necessity from correlative data, combine to render the mapping of brain function a far harder task than it seems. Methods capable of combining connective…

Large brain imaging databases contain a wealth of information on brain organization in the populations they target, and on individual variability. While such databases have been used to study group-level features of populations directly,…

Applications · Statistics 2019-06-19 Amanda F. Mejia , Mary Beth Nebel , Yikai Wang , Brian S. Caffo , Ying Guo

Contemporary computational neuroscience features two prominent modeling traditions. Bottom-up whole-brain modeling (WBM) builds biophysically detailed simulations of brain structure and dynamics, whereas top-down neuroconnectionism…

Neurons and Cognition · Quantitative Biology 2026-05-19 Mario Senden , Leonardo Dalla Porta , Jan Fousek , Jorge F. Mejias , Gorka Zamora-López

Foundation models (FMs), large neural networks pretrained on extensive and diverse datasets, have revolutionized artificial intelligence and shown significant promise in medical imaging by enabling robust performance with limited labeled…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Salah Ghamizi , Georgia Kanli , Yu Deng , Magali Perquin , Olivier Keunen

Brain Foundation Models (BFMs) are transforming neuroscience by enabling scalable and transferable learning from neural signals, advancing both clinical diagnostics and cutting-edge neuroscience exploration. Their emergence is powered by…

Machine Learning · Computer Science 2026-02-13 Fanqi Shen , Enhong Yang , Jiahe Li , Junru Hong , Xiaoran Pan , Zhizhang Yuan , Meng Li , Yang Yang

High-resolution functional imaging is providing increasingly rich measurements of brain activity in animals and humans. A major challenge is to leverage such data to gain insight into the brain's computational mechanisms. The first step is…

Neurons and Cognition · Quantitative Biology 2016-08-09 Nikolaus Kriegeskorte , Jörn Diedrichsen

Large-scale electrophysiological recordings now allow simultaneous monitoring of thousands of neurons across multiple brain regions, revealing structured variability in neural population activity. Understanding how these collective patterns…

Neurons and Cognition · Quantitative Biology 2026-03-12 Nicolas Béreux , Giovanni Catania , Aurélien Decelle , Francesca Mignacco , Alfonso de Jesús Navas Gómez , Beatriz Seoane

With the wide adoption of functional magnetic resonance imaging (fMRI) by cognitive neuroscience researchers, large volumes of brain imaging data have been accumulated in recent years. Aggregating these data to derive scientific insights…

Applications · Statistics 2020-06-01 Ming Bo Cai , Michael Shvartsman , Anqi Wu , Hejia Zhang , Xia Zhu

In recent years, Bayesian statistics methods in neuroscience have been showing important advances. In particular, detection of brain signals for studying the complexity of the brain is an active area of research. Functional magnetic…

Methodology · Statistics 2017-06-06 Jairo Alberto Fuquene Patiño , Brenda Betancourt , João B. M. Pereira

Brain connectivity analysis is crucial for understanding brain structure and neurological function, shedding light on the mechanisms of mental illness. To study the association between individual brain connectivity networks and the clinical…

Brain function is organized in coordinated modes of spatio-temporal activity (functional networks) exhibiting an intrinsic baseline structure with variations under different experimental conditions. Existing approaches for uncovering such…

Methodology · Statistics 2019-02-13 Joshua Lukemire , Suprateek Kundu , Giuseppe Pagnoni , Ying Guo

In structural brain networks the connections of interest consist of white-matter fibre bundles between spatially segregated brain regions. The presence, location and orientation of these white matter tracts can be derived using diffusion…

Neurons and Cognition · Quantitative Biology 2012-02-09 M. Hinne , T. Heskes , M. A. J. van Gerven

Latent manifolds provide a compact characterization of neural population activity and of shared co-variability across brain areas. Nonetheless, existing statistical tools for extracting neural manifolds face limitations in terms of…

Neurons and Cognition · Quantitative Biology 2022-09-08 Edoardo Balzani , Jean Paul Noel , Pedro Herrero-Vidal , Dora E. Angelaki , Cristina Savin

The human brain is a complex, dynamic network, which is commonly studied using functional magnetic resonance imaging (fMRI) and modeled as network of Regions of interest (ROIs) for understanding various brain functions. Recent studies…

Quantitative Methods · Quantitative Biology 2024-06-26 Yifan Yang , Yutong Mao , Xufu Liu , Xiao Liu

In neuroimaging, extensive post-processing of resting-state functional MRI (rfMRI) data is necessary for its application and investigation in relation to brain-behavior associations. Such post-processing is used to derive brain…

Computational Geometry · Computer Science 2025-09-11 Ty Easley , Kevin Freese , Elizabeth Munch , Janine Bijsterbosch

Individual differences in human intelligence can be modeled and predicted from in vivo neurobiological connectivity. Many established modeling frameworks for predicting intelligence, however, discard higher-order information about…

Neurons and Cognition · Quantitative Biology 2022-03-07 Evan D. Anderson , Ramsey Wilcox , Anuj Nayak , Christopher Zwilling , Pablo Robles-Granda , Been Kim , Lav R. Varshney , Aron K. Barbey