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Although deep learning models have achieved state-of-the-art performance on a number of vision tasks, generalization over high dimensional multi-modal data, and reliable predictive uncertainty estimation are still active areas of research.…

Machine Learning · Computer Science 2020-12-10 Samarth Sinha , Homanga Bharadhwaj , Anirudh Goyal , Hugo Larochelle , Animesh Garg , Florian Shkurti

We demonstrate the application of mixture density networks (MDNs) in the context of automated radiation therapy treatment planning. It is shown that an MDN can produce good predictions of dose distributions as well as reflect uncertain…

Medical Physics · Physics 2021-07-06 Viktor Nilsson , Hanna Gruselius , Tianfang Zhang , Geert De Kerf , Michaël Claessens

Scientific modeling faces a tradeoff between the interpretability of mechanistic theory and the predictive power of machine learning. While existing hybrid approaches have made progress by incorporating domain knowledge into machine…

Machine Learning · Computer Science 2026-04-15 Carson Dudley , Reiden Magdaleno , Christopher Harding , Marisa Eisenberg

Deep neural networks (DNNs) are often prone to learn the spurious correlations between target classes and bias attributes, like gender and race, inherent in a major portion of training data (bias-aligned samples), thus showing unfair…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Mei Wang , Weihong Deng , Jiani Hu , Sen Su

Scientific machine learning (SciML) is an interdisciplinary research field that integrates machine learning, particularly deep learning, with physics theory to understand and predict complex natural phenomena. By incorporating physical…

Geophysics · Physics 2025-03-24 Tomohisa Okazaki

Mixture Density Networks are a tried and tested tool for modelling conditional probability distributions. As such, they constitute a great baseline for novel approaches to this problem. In the standard formulation, an MDN takes some input…

Machine Learning · Computer Science 2020-03-13 Jakob Kruse

Albeit worryingly underrated in the recent literature on machine learning in general (and, on deep learning in particular), multivariate density estimation is a fundamental task in many applications, at least implicitly, and still an open…

Neural and Evolutionary Computing · Computer Science 2020-12-08 Edmondo Trentin

Future prediction is a fundamental principle of intelligence that helps plan actions and avoid possible dangers. As the future is uncertain to a large extent, modeling the uncertainty and multimodality of the future states is of great…

Computer Vision and Pattern Recognition · Computer Science 2020-06-09 Osama Makansi , Eddy Ilg , Özgün Cicek , Thomas Brox

In climate science, models for global warming and weather prediction face significant challenges due to the limited availability of high-quality data and the difficulty in obtaining it, making data efficiency crucial. In the past few years,…

Machine Learning · Computer Science 2024-10-10 Sameera S Kashyap , Raj Abhijit Dandekar , Rajat Dandekar , Sreedath Panat

Mixture Density Networks (MDNs) can be used to generate probability density functions of model parameters $\boldsymbol{\theta}$ given a set of observables $\mathbf{x}$. In some applications, training data are available only for discrete…

Data Analysis, Statistics and Probability · Physics 2021-08-18 Charles Burton , Spencer Stubbs , Peter Onyisi

Quantifying and propagating modeling uncertainties is crucial for reliability analysis, robust optimization, and other model-based algorithmic processes in engineering design and control. Now, physics-informed machine learning (PIML)…

Machine Learning · Computer Science 2025-07-14 Manaswin Oddiraju , Bharath Varma Penumatsa , Divyang Amin , Michael Piedmonte , Souma Chowdhury

Deep learning has revolutionized biomedical research by providing sophisticated methods to handle complex, high-dimensional data. Multimodal deep learning (MDL) further enhances this capability by integrating diverse data types such as…

Machine Learning · Computer Science 2026-03-13 Valerio Guarrasi , Fatih Aksu , Camillo Maria Caruso , Francesco Di Feola , Aurora Rofena , Filippo Ruffini , Paolo Soda

Diffusion models have emerged as powerful generative tools with applications in computer vision and scientific machine learning (SciML), where they have been used to solve large-scale probabilistic inverse problems. Traditionally, these…

Rapid and accurate simulations of fluid dynamics around complicated geometric bodies are critical in a variety of engineering and scientific applications, including aerodynamics and biomedical flows. However, while scientific machine…

While several methods for predicting uncertainty on deep networks have been recently proposed, they do not readily translate to large and complex datasets. In this paper we utilize a simplified form of the Mixture Density Networks (MDNs) to…

Machine Learning · Computer Science 2019-12-05 Nicholas Wilkins , Michael Johnson , Ifeoma Nwogu

Deep neural networks have amply demonstrated their prowess but estimating the reliability of their predictions remains challenging. Deep Ensembles are widely considered as being one of the best methods for generating uncertainty estimates…

Machine Learning · Computer Science 2021-06-28 Nikita Durasov , Timur Bagautdinov , Pierre Baque , Pascal Fua

The application of machine learning in sciences has seen exciting advances in recent years. As a widely applicable technique, anomaly detection has been long studied in the machine learning community. Especially, deep neural nets-based…

Machine Learning · Statistics 2023-11-03 Taoli Cheng

A generative modeling framework is proposed that combines diffusion models and manifold learning to efficiently sample data densities on manifolds. The approach utilizes Diffusion Maps to uncover possible low-dimensional underlying (latent)…

Machine Learning · Computer Science 2025-04-22 Dimitris G. Giovanis , Ellis Crabtree , Roger G. Ghanem , Ioannis G. Kevrekidis

Deep neural network (DNN) models have achieved phenomenal success for applications in many domains, ranging from academic research in science and engineering to industry and business. The modeling power of DNN is believed to have come from…

Machine Learning · Computer Science 2024-10-08 Beomseok Seo , Lin Lin , Jia Li

Machine learning methods and uncertainty quantification have been gaining interest throughout the last several years in low-energy nuclear physics. In particular, Gaussian processes and Bayesian Neural Networks have increasingly been…

Nuclear Theory · Physics 2022-07-27 A. E. Lovell , A. T. Mohan , T. M. Sprouse , M. R. Mumpower